SPSB2 Human

SPSB2 Human

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  • Name :

    SPSB2 Human

    Description:

    SPRY Domain-Containing SOCS Cox Protein 2 Human Recombinant

    SPRY domain-containing SOCS box protein 2, SSB-2, Gene-rich cluster protein C9, SPSB2, GRCC9, SSB2, GRCC9.

    Product # :

    PRO-1264

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  • More Info

Description

SPSB2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 287 amino acids (1-263 a.a) and having a molecular mass of 31.2kDa.SPSB2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

SPSB2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

Purity

Greater than 85.0% as determined by SDS-PAGE.

More Info

  • Introduction

    SPRY Domain-Containing SOCS Cox Protein 2 (SPSB2) belongs to a suppressor of cytokine signaling (SOCS) family, and is a member of the subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal SOCS box. SPSB2 is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. SPSB2 is apparent substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and ensuing proteasomal degradation of target proteins.

  • Synonyms

    SPRY domain-containing SOCS box protein 2, SSB-2, Gene-rich cluster protein C9, SPSB2, GRCC9, SSB2, GRCC9.

  • Physical Appearance

    Sterile Filtered colorless solution.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Amino Acid Sequence

    MGSSHHHHHH SSGLVPRGSH MGSHMGQTAL AGGSSSTPTP QALYPDLSCP EGLEELLSAP PPDLGAQRRH GWNPKDCSEN IEVKEGGLYF ERRPVAQSTD GARGKRGYSR GLHAWEISWP LEQRGTHAVV GVATALAPLQ TDHYAALLGS NSESWGWDIG RGKLYHQSKG PGAPQYPAGT QGEQLEVPER LLVVLDMEEG TLGYAIGGTY LGPAFRGLKG RTLYPAVSAV WGQCQVRIRY LGERRAEPHS LLHLSRLCVR HNLGDTRLGQ VSALPLPPAM KRYLLYQ.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Spsb2 Human

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