PEDF Human

PEDF Human

Neurotrophins

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  • Name :

    PEDF Human

    Description:

    Pigment Epithelium-Derived Factor Human Recombinant

    Pigment epithelium-derived factor,PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35.

    Product # :

    CYT-580

    Price :

    Quantity :

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    Shipped at Room temp

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  • More Info

Description

PEDF Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 400 amino acids and having a molecular mass of 44.5 kDa. The Human PEDF is purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

The sterile filtered concentrated (1mg/ml) protein solution was lyophilized with 20mM sodium phosphate buffer & 150mM NaCl pH-7.4.

Purity

Greater than 95% as determined by SDS-PAGE.

More Info

  • Introduction

    PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuro-protective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF in addition has the potential to be functional in the treatment of various angiogenesis-related diseases including a number of cancers.

  • Synonyms

    Pigment epithelium-derived factor,PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35.

  • Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

  • Stability

    Lyophilized PEDF although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PEDF Human should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

  • Solubility

    It is recommended to reconstitute the lyophilized PEDF in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

  • Amino Acid Sequence

    MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AVLRYGLDSD LSCKIAQLPL TGSMSIIFFL PLKVTQNLTL IEESLTSEFI HDIDRELKTV QAVLTVPKLK LSYEGEVTKS LQEMKLQSLF DSPDFSKITG KPIKLTQVEH RAGFEWNEDG AGTTPSPGLQ PAHLTFPLDY HLNQPFIFVL RDTDTGALLF IGKILDPRGP.

  • Background

    About PEDF Human

    Also known as “Pigment Epithelium-Derived Factor” or “SERPINF1,” PEDF is a
    multifunctional protein found in vertebrates. It has anti-tumorigenic, anti-angiogenic, and
    neurotrophic functions. Currently, it’s being researched as a candidate for treatment for
    several conditions, including heart disease and cancer.

    What’s the Function of PEDF Human Recombinant?

    PEDF is created/secreted in several tissues across the body. It has a unique anti-angiogenic
    action because of its induction of apoptosis in proliferating endothelial cells. Also, PEDF
    can inhibit many angiogenic factors, including VEGF and FGF-2. PEDF-R is currently the
    only known signaling receptor to be used by a serpin family member.


    What’s the Application of PEDF Human Recombinant?

    This version of PEDF is produced in E. Coli. It’s a single, non-glycosylated, polypeptide
    chain that contains 400 amino acids. It has a molecular mass of 44.5 kDa, and it’s purified
    by proprietary chromatographic techniques.

    The main purpose of PEDF human recombinant is for research. It has the potential to
    become a potential treatment for different angiogenesis-related diseases, including
    various cancers. Moreover, it can become crucial during the recovery from vasculature-
    related neurodegenerative illness.

    Such a discovery could be revolutionary for the world, which is why more research is
    needed to determine the effect of this non-inhibitory serpin on the body.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Serpinf1 Human

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