RGS1 Human

RGS1 Human

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  • Name :

    RGS1 Human

    Description:

    Regulator of G-Protein Signaling 1 Human Recombinant

    Regulator of G-protein signaling 1, RGS1, B-cell activation protein BL34, Early response protein 1R20, 1R20, BL34, IER1, IR20.

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    PRO-1118

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Description

RGS1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 233 amino acids (1-209 a.a) and having a molecular mass of 26kDa.RGS1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

RGS1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

Purity

Greater than 90% as determined by SDS-PAGE.

More Info

  • Introduction

    RGS1 belongs to the regulator of G-protein signaling family. The RGS1 protein is situated on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif termed the RGS domain. RGS1 diminish s the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and performing as a GTPase activating protein (GAP), boosting the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, creating inactive G-protein heterotrimers, thus terminating the signal.

  • Synonyms

    Regulator of G-protein signaling 1, RGS1, B-cell activation protein BL34, Early response protein 1R20, 1R20, BL34, IER1, IR20.

  • Physical Appearance

    Sterile Filtered colorless solution.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Amino Acid Sequence

    MGSSHHHHHH SSGLVPRGSH MGSHMRAAAI STPKLDKMPG MFFSANPKEL KGTTHSLLDD KMQKRRPKTF GMDMKAYLRS MIPHLESGMK SSKSKDVLSA AEVMQWSQSL EKLLANQTGQ NVFGSFLKSE FSEENIEFWL ACEDYKKTES DLLPCKAEEI YKAFVHSDAA KQINIDFRTR
    ESTAKKIKAP TPTCFDEAQK VIYTLMEKDS YPRFLKSDIY LNLLNDLQAN SLK.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Rgs1 Human

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