Recombinant HER2 Antibody

Recombinant HER2 Antibody

Anti Human Enzyme

Name

Description

Product #

Price

Quantity

Shipping Method

  • Name :

    Recombinant HER2 Antibody

    Description:

    Recombinant Human Anti HER2

    Product # :

    ANT-602

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add :

  • description
  • source
  • formulation
  • purity
  • biological activity
  • More Info

Description

Recombinant Human Anti HER2 is produced by recombinant DNA technology in a Chinese Hamster Ovary mammalian cell expression system in a serum-free medium and has a molecular weight of approximately 148 kDa.

Source

CHO.

Formulation

Each ml of Recombinant HER2 Antibody solution (32.1mg/ml) contains 0.56mg histidine-HCl, 0.36mg histidine and 0.1mg polysorbate-20, pH-6.

Purity

Should be not less than 95.0% as determined by:
(a) Analysis by SEC-HPLC.
(b) Analysis by SDS-PAGE.

Biological Activity

The ED50 as determined by the proliferation inhibition of BT474 cell, Perform a comparison of a dilution series of the Sample solution with a dilution series of the Standard solution, measured potency was found to be 0.9 x 104EU/mg.

More Info

  • Introduction

    HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.

  • Physical Appearance

    Sterile filtered colorless liquid formulation.

  • Stability

    Recombinant Human Anti HER2 should be stored between 2-8°C.

  • Amino Acid Sequence

    LIGHT CHAIN
    DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQ
    KPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSL
    QPEDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFI
    FPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQ
    SGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYAC
    EVTHQGLSSPVTKSFNRGEC.

    HEAVY CHAIN
    EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVR
    QAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSK
    NTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQ
    GTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKD
    YFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVT
    VPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCP
    PCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVS
    HEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSV
    LTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPR
    EPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWE
    SNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQ
    GNVFSCSVMHEALHNHYTQKSLSLSPGK.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Recombinant Her2 Antibody

You may also like