PSME3 Human

PSME3 Human

Enzymes

Name

Description

Product #

Price

Quantity

Shipping Method

  • Name :

    PSME3 Human

    Description:

    Proteasome Activator Subunit 3 Human Recombinant

    Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki), PA28G, Ki, Ki nuclear autoantigen, PA28-gamma, REG-GAMMA, Activator of multicatalytic protease subunit 3, Proteasome activator 28 subunit gamma, 11S regulator complex subunit gamma, PA28gamma,

    Product # :

    PRO-987

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add :

  • description
  • source
  • formulation
  • purity
  • More Info

Description

PSME3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 274 amino acids (1-254 a.a.) and having a molecular mass of 31.7kDa. PSME3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Source

E.coli.

Formulation

PSME3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 200mM NaCl, 2mM DTT and 40% glycerol.

Purity

Greater than 90% as determined by SDS-PAGE.

More Info

  • Introduction

    PSME3 is a member of the PA28 family. The 26S proteasome is an extremely organized multicatalytic proteinase complex composed of 2 complexes, a 20S core and a 19S regulator. Proteasomes are spread all over the eukaryotic cells in large quantities and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. PSME3 stimulates the trypsin-like catalytic subunit of the proteasome and inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. PSEM3 enables the MDM2-p53/TP53 collaboration that encourages ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, restricting its growth and causing inhibited apoptosis after DNA damage.

  • Synonyms

    Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki), PA28G, Ki, Ki nuclear autoantigen, PA28-gamma, REG-GAMMA, Activator of multicatalytic protease subunit 3, Proteasome activator 28 subunit gamma, 11S regulator complex subunit gamma, PA28gamma,

  • Physical Appearance

    Sterile Filtered colorless solution.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Amino Acid Sequence

    MGSSHHHHHH SSGLVPRGSH MASLLKVDQE VKLKVDSFRE RITSEAEDLV ANFFPKKLLE LDSFLKEPIL NIHDLTQIHS DMNLPVPDPI LLTNSHDGLD GPTYKKRRLD ECEEAFQGTK VFVMPNGMLK SNQQLVDIIE KVKPEIRLLI EKCNTVKMWV QLLIPRIEDG NNFGVSIQEE TVAELRTVES EAASYLDQIS RYYITRAKLV SKIAKYPHVE DYRRTVTEID EKEYISLRLI ISELRNQYVT LHDMILKNIE KIKRPRSSNA ETLY

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Psme3 Human

You may also like