PI3Kb Human

PI3Kb Human

Enzymes

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  • Name :

    PI3Kb Human

    Description:

    Phosphoinositide 3-kinase beta p110β/p85α Human Recombinant

    Phosphoinositide 3-kinase beta p110b/p85a, PI3Kb, PI3Kb.

    Product # :

    PKA-333

    Price :

    Quantity :

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  • description
  • source
  • formulation
  • purity
  • biological activity
  • More Info

Description

Phosphoinositide 3-kinase beta Human Recombinant is a glycosilated protein having a molecular weight as follows: p85a chain 83.5 kDa, p110b chain 124.3 kDa.

Source

Sf9 insect cells.

Formulation

0.9 mg/ml solution in PBS and 2mM MgCl2.

Purity

Greater than 90.0% as determined by SDS Page.

Biological Activity

The specific activity was found to be 3,000 units/mg (1 unit is defined as 1 picomole phosphate transferred to PIP2 per minute).

More Info

  • Introduction

    The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of
    PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin receptor substrate (IRS) proteins (e.g. IRS-1 and IRS-2).
    It was also shown that PI3Kb is involved in apoptosis in human colon carcinoma cells. Injection of neutralizing antibodies specific to p110b in WiDr,
    HCT116 and CO 115 adenocarcinoma cells inhibited de novo DNA synthesis.
    PI3Kb is the major PI3K isoform required for apoptotic cell and Fc-g receptor mediated phagocytosis shown for primary mouse macrophages and the Jurkat human leukemia T cell line.
    It was shown by several research groups that the catalytic subunit of PI3Kb can be activated by Gbg subunits of G-protein coupled receptors.

  • Synonyms

    Phosphoinositide 3-kinase beta p110b/p85a, PI3Kb, PI3Kb.

  • Physical Appearance

    Sterile filtered liquid formualtion.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Pi3Kb Human

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