Phospholipase A2

Phospholipase A2

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  • Name :

    Phospholipase A2

    Description:

    Phospholipase A2 P00630 Bee Venom Protein Recombinant

    Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Allergen Api m I, Api m 1.

    Product # :

    ALR-001

    Price :

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Description

The E.Coli derived recombinant protein contains phospholipase P00630 bee venom protein epitopes, 26-162 amino acids. Phospholipase A2 P00630 Bee Venom is fused to a 6xHis tag at C-terminus

Source

Escherichia Coli.

Formulation

1XPBS pH 7.2 and 50% glycerol.

Purity

Protein is >90% pure as determined by 10% SDS-PAGE.

More Info

  • Introduction

    Bee venom phospholipase A2 (PLA) is the main allergen in the bee sting allergy. Bee venom phospholipase A2 (BV-PLA2) is a hydrolytic enzyme which specifically cleaves the sn-2 acyl bond of phospholipids at the lipid/water interface. BV-PLA2 is a 14–16-kDa glycoprotein, consisting of 134 amino acids and displaying a single carbohydrate side chain at the residue Asn13. It is also held to be responsible for some systemic anaphylactic reactions in bee venom sensitized individuals. BV-PLA2 presents 3 peptide and a glycopeptide T cell epitopes, which are recognized by both allergic and non-allergic bee venom sensitized subjects. PLA is able to elicit both IgE mediated allergy and normal immunity to bee sting which usually is associated with high affinity IgG4 anti-PLA antibodies.

  • Synonyms

    Phospholipase A2, Phosphatidylcholine 2-acylhydrolase, Allergen Api m I, Api m 1.

  • Stability

    Phospholipase A2 although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

  • Purification Method

    Purified by proprietary chromatographic technique.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Phospholipase A2

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