PCNA Antibody

PCNA Antibody

Monoclonal Antibodies

Name

Description

Product #

Price

Quantity

Shipping Method

  • Name :

    PCNA Antibody

    Description:

    Proliferating Cell Nuclear Antigen, Mouse Anti Human

    Proliferating cell nuclear antigen, PCNA, Cyclin, MGC8367.

    Product # :

    ANT-341

    Price :

    Quantity :

    Shipping Method :

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    Shipped with Ice Packs

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  • formulation
  • More Info

Formulation

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

More Info

  • Introduction

    PCNA is located in the nucleus and is a cofactor of DNA polymerase delta. PCNA acts as a homotrimer and helps elevate the processivity of leading strand synthesis during DNA replication. In reaction to DNA damage, PCNA is ubiquitinated and takes part in the RAD6-dependent DNA repair pathway. 2 transcript variants encoding the same protein have been found for PCNA gene. Pseudogenes of this PCNA gene have been described on chromosome 4 and on the X chromosome. PCNA is expressed during late G1- phase, S-phase of mitosis and persists until the end of the M-phase because of its long biological half-life. PCNA is induced by UV irradiation.

  • Synonyms

    Proliferating cell nuclear antigen, PCNA, Cyclin, MGC8367.

  • Immunogen

    Anti-human PCNA mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PCNA amino acids 1-261 purified from E. coli.

  • Ig Subclass

    Mouse IgG3 heavy chain and κ light chain.

  • Clone

    Pk1A3AT.

  • Applications

    The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results.

  • Type

    Mouse Anti Human Monoclonal.

  • Storage Procedures

    For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

  • Purification Method

    PCNA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Pcna Antibody

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