MSH6 Human

MSH6 Human

Other

Name

Description

Product #

Price

Quantity

Shipping Method

  • Name :

    MSH6 Human

    Description:

    MutS Homolog 6 Human Recombinant

    MSH6, GTBP, HNPCC5, HSAP, DNA mismatch repair protein Msh6, MutS-alpha 160 kDa subunit, G/T mismatch-binding protein, hMSH6, p160, GTMBP.

    Product # :

    PRO-745

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add :

  • description
  • source
  • formulation
  • More Info

Description

MSH6 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 51 amino acids (350-400 a.a.) having a total Mw of 33 kDa. Human MSH6 is fused to a GST tag and purified by proprietary chromatographic techniques.

Source

Escherichia Coli.

Formulation

MSH6 is supplied in 50mM Tris-HCl, pH-7.5, 10mM L-glutathione (reduced).

More Info

  • Introduction

    MSH6 deficiency result in hereditary non-polyposis colorectal cancer (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease linked with rise in cancer susceptibility. MSH6 is is known by its familial predisposition to premature onset colorectal carcinoma (crc).
    MSH6 is involved in repairing DNA. MSH6 protein repairs mistakes that occure during DNA replication in preparation for cell division. The MSH6 protein bonds with MSH2 protein and form an active protein complex which recognizes specific parts on the DNA where mistakes have been made during DNA replication. MLH1-PMS2 protein complex, afterwards takes over with the repair. MSH6 gene is part of the set of the mismatch repair (MMR) genes.

  • Synonyms

    MSH6, GTBP, HNPCC5, HSAP, DNA mismatch repair protein Msh6, MutS-alpha 160 kDa subunit, G/T mismatch-binding protein, hMSH6, p160, GTMBP.

  • Physical Appearance

    Sterile Filtered clear solution.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Msh6 Human

You may also like