MMP12 Human

MMP12 Human

Enzymes

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Description

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  • Name :

    MMP12 Human

    Description:

    Matrix Metalloproteinase 12 Human Recombinant

    Product # :

    ENZ-1200

    Price :

    Quantity :

    Shipping Method :

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    Shipped at Room temp

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Description

The MMP12 Human is created as a recombinant protein with a 4kda N-terminal fusion of His Tag. The MMP12 His-Tagged Fusion Protein, produced in E. coli, is a 15kDa protein containing 83 amino acid residues of the MMP12 Human, 35-117 amino acids.

Source

Escherichia Coli.

Formulation

Each mg was lyophilized with 1xPBS, 0.4% SDS and 4mM DTT.

Purity

Greater than 90% as determined by SDS-PAGE.

More Info

  • Physical Appearance

    Filtered White lyophilized (freeze-dried) powder.

  • Stability

    Store lyophilized MMP12 at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

  • Solubility

    It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture.

  • Amino Acid Sequence

    LRYLEKFYGL EINKLPVTKM KYSGNLMKEK IQEMQHFLGL KVTGQLDTST LEMMHAPRCG VPDVHHFREM PGGPVWRKHY ITYR.

  • Background

    MMPs are a family of zinc-dependent enzymes which take part in the degradation of the extracellular matrix. These enzymes are involved in various physiological processes, including wound healing, tissue remodeling, immune response and embryogenesis. Matrix Metalloproteinase 12 also known as MMP12 is 1 of the main enzymes in the MMP family which is primarily produced by macrophages and neutrophils. MMP12 is implicated in the breakdown of elastin and in the development of chronic inflammatory diseases, such as emphysema, COPD and atherosclerosis. MMP12 is a key enzyme in the degradation of the extracellular matrix, especially elastin which provides structural integrity to tissues like the skin, lungs and blood vessels. MMP12 catalyzes the cleavage of collagen, elastin and other ECM components. Its activity is regulated in normal tissues to avoid pathological degradation.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Mmp12 Human

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