MHC CLASS II, I-E Antibody, FITC

MHC CLASS II, I-E Antibody, FITC

Monoclonal Antibodies

Name

Description

Product #

Price

Quantity

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  • Name :

    MHC CLASS II, I-E Antibody, FITC

    Description:

    MHC CLASS II, (I-E) Mouse Antibody, FITC

    Product # :

    ANT-299

    Price :

    Quantity :

    Shipping Method :

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    Shipped at Room temp

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  • formulation
  • More Info

Formulation

1mg/ml in PBS (after reconstitution).

More Info

  • Introduction

    MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.

  • Solubility

    Reconstitute with of H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

  • Immunogen

    Purified mouse LN B cells (C3H anti-C57Bl6).

  • Ig Subclass

    Mouse IgG2a.

  • Clone

    NYRmI-E.

  • Applications

    Cytotoxic and staining antibody. For staining, use 10ml/1,000,000 cells. Titer for cytotoxicity should be determined by the investigator.

  • Specificity

    Recognizes most MHC I-E class II haplotypes Reacts with H-2k, H-2d, H-2p and H-2r.

  • Available Conjugates

    This antibody is also available as unconjugated antibody and conjugated to Biotin.

  • Type

    Mouse Antibody Monoclonal.

  • Storage Procedures

    Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

  • Purification Method

    Ion exchange column.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Mhc Class Ii I E Antibody Fitc

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