LAIR1 Human

LAIR1 Human

Leukocyte-Associated Ig-Like Receptor

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  • Name :

    LAIR1 Human

    Description:

    Leukocyte-Associated Ig-Like Receptor 1 Human Recombinant

    Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305.

    Product # :

    PRO-431

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  • More Info

Description

LAIR1 Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 105 and having a molecular mass of 11.5 kDa. The extracellular domain of LAIR-1 (22-125aa) was overexpressed in E.coli, and purified by using conventional chromatography techniques.

Source

Escherichia Coli.

Formulation

The protein (1mg/ml) contains 20mM Tris-HCl (pH7.5) 50mM NaCl and 1mM EDTA.

Purity

Greater than 95.0% as determined by SDS-PAGE.

More Info

  • Introduction

    LAIR1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region.
    LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

  • Synonyms

    Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, CD305 antigen, LAIR1, CD305.

  • Physical Appearance

    Sterile filtered colorless solution.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Amino Acid Sequence

    MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Lair1 Human

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