CXCL8 Canine, HEK

CXCL8 Canine, HEK

Chemokines

Name

Description

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Price

Quantity

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  • Name :

    CXCL8 Canine, HEK

    Description:

    Interleukin-8, HEK Canine Recombinant

    Interleukin-8, IL-8, C-X-C motif chemokine 8, IL8, CXCL8

    Product # :

    CHM-045

    Price :

    Quantity :

    Shipping Method :

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    Shipped with Ice Packs

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  • source
  • formulation
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  • More Info

Description

IL8 Canine, HEK Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 80 amino acids (28-101 a.a) and having a molecular mass of 9.4 kDa.IL8 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

Source

HEK293 Cells.

Formulation

The IL8 solution (0.25mg/1ml) contains phosphate buffered saline (pH7.4) and 20% glycerol.

Purity

Greater than 90.0% as determined by SDS-PAGE.

More Info

  • Introduction

    Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. IL8 is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies.When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

  • Synonyms

    Interleukin-8, IL-8, C-X-C motif chemokine 8, IL8, CXCL8

  • Physical Appearance

    Sterile filtered colorless solution.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Amino Acid Sequence

    VSSELRCQCI KTHSTPFHPK YIKELRVIDS GPHCENSEII VKLFNGNEVC LDPKEKWVQK VVQIFLKKAE KQDPHHHHHH

  • Background

    What is the molecular weight/Mw of CXCL8 CANINE, HEK Protein?
    CXCL8 CANINE, HEK Protein has a total Mw of 9.4kDa.

    What is the source or expression system of CXCL8 CANINE, HEK Protein?
    HEK293 Cells.

    What is the Purity of CXCL8 CANINE, HEK Protein?
    CXCL8 CANINE, HEK Protein is >90% pure as determined by SDS-PAGE.

    What is the Biological Activity of CXCL8 CANINE, HEK Protein?
    The biological functionality of CXCL8 CANINE, HEK Protein will be determined in the future.

    What is the amino acid sequence of CXCL8 CANINE, HEK Protein?
    VSSELRCQCI KTHSTPFHPK YIKELRVIDS GPHCENSEII VKLFNGNEVC LDPKEKWVQK VVQIFLKKAE KQDPHHHHHH

    What applications can CXCL8 CANINE, HEK Protein be used in?
    CXCL8 CANINE, HEK Protein can probably be used in western blot, ELISA and Lateral Flow.

    What is the endotoxin level for CXCL8 CANINE, HEK Protein?
    The endotoxin level is minimal, CXCL8 CANINE, HEK Protein was purified using conventional chromatography techniques.

    Who supplies recombinant CXCL8 CANINE, HEK that is in stock and available to order?
    ProSpec has the protein in stock and available for immediate delivery.

    Where can I order bulk mg quantities of CXCL8 CANINE, HEK?
    ProSpec supplies bulk mg quantities at affordable prices that meets research and academic budgets.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Il8 Canine

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Frequently asked questions

1. Which company offers Recombinant Chemokines at competitive prices?

ProSpec offers vast array of Chemokines such as Eotaxin | Fractalkine | IL-8 | Rantes and much more at affordable descent prices to meet academic budgets
ProSpec provides High Purity Chemokines for 30 years, purity exhibits 95% and more as visualized by SDS-PAGE gel.
Chemokines are in stock for immediate delivery via FedEx which enables scientists and researchers to perform immediate experiments.
Chemokines are shipped globally using ProSpec’s custom tailored Styrofoam insulated box and premium ice packs that ensure maximum protein stability during transit to your laboratory.

2. Who can produce a custom Chemokine ?

ProSpec custom produces recombinant chemokines starting from Gene Design, Gene cloning, Expression Screening, Fermentation + protein expression, Cell harvesting + disruption, Protein recovery and purification to Q.C. formulation and filling, lyophilization is offered as an option.

3. What is the production time for a custom Chemokine?

The production time for a custom recombinant chemokine protein may vary between 5-7 weeks.

4. Where can i find biologically active Chemokines?

ProSpec offers biologically functional Chemokines such as SDF1A | Platelet Factor-4 | MCP1 which are rigorously tested in-vitro to provide researchers world wide BioActive Chemokines.

5. What is the difference between CC, CXC, CX3C, and XC chemokines?

Chemokines are a superfamily of small, secreted signaling proteins that direct the migration of immune cells, they are classified into 4 subfamilies based on the spacing of the cysteine residues near their N-terminus. CC and CXC are the largest families, while CX3C and XC contain fewer members. You can find CXC chemokines and CC chemokines at ProSpecBio such as cat# chm-348 Recombinant Human BCA-1/ BLC (CXCL13), cat# chm-001, Recombinant Human BRAK (CXCL14), cat#
chm-029, Recombinant Human CXCL16, cat# chm-331 Recombinant Human ENA78 (CXCL5) and more....

6. Which receptors bind to a specific chemokine?

Chemokines mainly bind G-protein-coupled receptors ( GPCR ), located on the surfaces of target cells. They match the structural classification of their ligands. Chemokines bind more than one receptor. For instance, CCL2 primarily binds CCR2, while CXCL12 binds CXCR4 and ACKR3. You can find CCL2 chemokine at ProSpecBio cat# chm-271, MCP1.