CXCL11 Mouse

CXCL11 Mouse

Chemokines

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Description

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  • Name :

    CXCL11 Mouse

    Description:

    I-TAC (CXCL11) Mouse Recombinant

    C-X-C motif chemokine 11, I-TAC, Small-inducible cytokine B11, Cxcl11, Scyb11.

    Product # :

    CHM-026

    Price :

    Quantity :

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    Shipped at Room temp

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  • description
  • source
  • formulation
  • purity
  • biological activity
  • More Info

Description

I TAC Mouse Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 79 amino acids and having a molecular mass of 9.1kDa.

Source

Escherichia Coli.

Formulation

I TAC protein was lyophilized from a 0.2 µm filtered concentrated solution in 10 mM Sodium Citrate, pH 4.0, with 600 mM NaCl.

Purity

Greater than 98.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

Biological Activity

Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine CXCR3 transfected 293 cells is in a concentration of 10-100 ng/ml corresponding to a specific activity of 10,000-100,000 IU/mg.

More Info

  • Introduction

    Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokinen family. I-TAC is highly expressed in peripheral blood leukocytes, pancreas and liver, with moderate levels in thymus, spleen and lung and low expression levels were in small intestine, placenta and prostate. Gene expression of CXCL11 is strongly induced by IFN-g and IFN-b, and weakly induced by IFN-a. The I-TACchemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10. I-TAC is chemotactic for activated T cells.The CXCL11 gene is located on human chromosome 4 along with many other members of the CXC chemokine family.

  • Synonyms

    C-X-C motif chemokine 11, I-TAC, Small-inducible cytokine B11, Cxcl11, Scyb11.

  • Physical Appearance

    Sterile Filtered White lyophilized (freeze-dried) powder.

  • Stability

    Lyophilized I TAC although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution I TAC should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

  • Solubility

    It is recommended to reconstitute the lyophilized I TAC in sterile 18M-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

  • Amino Acid Sequence

    FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM.

  • Background

    What is the molecular weight/Mw of CXCL11 MOUSE Protein?
    CXCL11 MOUSE Protein has a total Mw of 9.1kDa.

    What is the source or expression system of CXCL11 MOUSE Protein?
    Escherichia Coli.

    What is the Purity of CXCL11 MOUSE Protein?
    CXCL11 MOUSE Protein is >98% pure as determined by SDS-PAGE.

    What is the Biological Activity of CXCL11 MOUSE Protein?
    Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using murine CXCR3 transfected 293 cells is in a concentration of 10-100 ng/ml corresponding to a specific activity of 10,000-100,000 IU/mg.

    What is the amino acid sequence of CXCL11 MOUSE Protein?
    FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM.

    What applications can CXCL11 MOUSE Protein be used in?
    CXCL11 MOUSE Protein can probably be used in western blot, ELISA and Lateral Flow.

    What is the endotoxin level for CXCL11 MOUSE Protein?
    The endotoxin level is minimal, CXCL11 MOUSE Protein was purified using conventional chromatography techniques.

    Who supplies recombinant CXCL11 MOUSE that is in stock and available to order?
    ProSpec has the protein in stock and available for immediate delivery.

    Where can I order bulk mg quantities of CXCL11 MOUSE?
    ProSpec supplies bulk mg quantities at affordable prices that meets research and academic budgets.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

I Tac Mouse

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Frequently asked questions

1. Which company offers Recombinant Chemokines at competitive prices?

ProSpec offers vast array of Chemokines such as Eotaxin | Fractalkine | IL-8 | Rantes and much more at affordable descent prices to meet academic budgets
ProSpec provides High Purity Chemokines for 30 years, purity exhibits 95% and more as visualized by SDS-PAGE gel.
Chemokines are in stock for immediate delivery via FedEx which enables scientists and researchers to perform immediate experiments.
Chemokines are shipped globally using ProSpec’s custom tailored Styrofoam insulated box and premium ice packs that ensure maximum protein stability during transit to your laboratory.

2. Who can produce a custom Chemokine ?

ProSpec custom produces recombinant chemokines starting from Gene Design, Gene cloning, Expression Screening, Fermentation + protein expression, Cell harvesting + disruption, Protein recovery and purification to Q.C. formulation and filling, lyophilization is offered as an option.

3. What is the production time for a custom Chemokine?

The production time for a custom recombinant chemokine protein may vary between 5-7 weeks.

4. Where can i find biologically active Chemokines?

ProSpec offers biologically functional Chemokines such as SDF1A | Platelet Factor-4 | MCP1 which are rigorously tested in-vitro to provide researchers world wide BioActive Chemokines.

5. What is the difference between CC, CXC, CX3C, and XC chemokines?

Chemokines are a superfamily of small, secreted signaling proteins that direct the migration of immune cells, they are classified into 4 subfamilies based on the spacing of the cysteine residues near their N-terminus. CC and CXC are the largest families, while CX3C and XC contain fewer members. You can find CXC chemokines and CC chemokines at ProSpecBio such as cat# chm-348 Recombinant Human BCA-1/ BLC (CXCL13), cat# chm-001, Recombinant Human BRAK (CXCL14), cat#
chm-029, Recombinant Human CXCL16, cat# chm-331 Recombinant Human ENA78 (CXCL5) and more....

6. Which receptors bind to a specific chemokine?

Chemokines mainly bind G-protein-coupled receptors ( GPCR ), located on the surfaces of target cells. They match the structural classification of their ligands. Chemokines bind more than one receptor. For instance, CCL2 primarily binds CCR2, while CXCL12 binds CXCR4 and ACKR3. You can find CCL2 chemokine at ProSpecBio cat# chm-271, MCP1.