HCV NS3 (1192-1459 a.a.)

HCV NS3 (1192-1459 a.a.)

Hepatitis C

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  • Name :

    HCV NS3 (1192-1459 a.a.)

    Description:

    Hepatitis C Virus NS3 Genotype-1b, (1192-1459 a.a.) Recombinant

    Product # :

    HCV-247

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  • formulation
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Description

The E.coli derived recombinant protein contains the HCV NS3 immunodominant regions, amino acids 1192-1459. The protein is fused to a GST tag at N-Terminus.

Formulation

1.5M urea, 25mM Tris-HCl pH-8, 0.2% Triton-X & 50% Glycerol.

Purity

HCV NS3 Genotype-1b protein is >95% pure as determined by 10% PAGE (coomassie staining).

More Info

  • Introduction

    HCV is a small 50nm, enveloped, single-stranded, positive sense RNA virus in the family Flaviviridae.
    HCV has a high rate of replication with approximately one trillion particles produced each day in an infected individual. Due to lack of proofreading by the HCV RNA polymerase, the HCV has an exceptionally high mutation rate, a factor that may help it elude the host's immune response. Hepatitis C virus is classified into six genotypes(1-6) with several subtypes within each genotype. The preponderance and distribution of HCV genotypes varies globally. Genotype is clinically important in determining potential response to interferon-based therapy and the required duration of such therapy. Genotypes 1 and 4 are less responsive to interferon-based treatment than are the other genotypes (2, 3, 5 and 6).

  • Stability

    NS3 Genotype-1b although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

  • Applications

    ELISA, Western blots and Flow-through.

  • Specificity

    Immunoreactive with sera of HCV-infected individuals.

  • Purification Method

    HCV NS3 Genotype-1b protein was purified by proprietary chromatographic technique.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Hcv Ns3 Genotype 1B 1192 1459

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