GLUD1 Human

GLUD1 Human

Dehydrogenase

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Description

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  • Name :

    GLUD1 Human

    Description:

    Glutamate Dehydrogenase 1 Human Recombinant

    Glutamate Dehydrogenase 1, GLUD, GDH 1, EC 1.4.1.3, GDH, GDH1, Glutamate Dehydrogenase (NAD(P)+), Glutamate Dehydrogenase 1 Mitochondrial, EC 1.4.1, GLUD1.

    Product # :

    ENZ-792

    Price :

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  • formulation
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  • More Info

Description

GLUD1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 528 amino acids (54-558) and having a molecular mass of 58.4kDa.GLUD1 is fused to a 23 amino acid His-tag at N-terminus.

Source

Escherichia Coli.

Formulation

The GLUD1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

Purity

Greater than 80.0% as determined by SDS-PAGE.

More Info

  • Introduction

    Glutamate dehydrogenase 1, mitochondrial precursor (GLUD1) is a member of the Glu/Leu/Phe/Val dehydrogenases family. GLUD1 is a mitochondrial glutamate dehydrogenase, which converts L-glutamate into alpha-ketoglutarate. GLUD1 has a pivotal role in nitrogen metabolism in plants and animals. GLUD1 is observed in all organisms and catalyzes the oxidative deamination of 1-glutamate to 2-oxoglutarate. The GLUD1 enzyme has a vital role in regulating amino acid induced insulin secretion. GLUD1 gene mutations cause hyperinsulinism-hyperammonemia syndrome (HHS), which is an inherited condition characterized by high insulin and ammonia levels in the blood. GLUD1 enzyme is allosterically activated by ADP and inhibited by GTP and ATP.

  • Synonyms

    Glutamate Dehydrogenase 1, GLUD, GDH 1, EC 1.4.1.3, GDH, GDH1, Glutamate Dehydrogenase (NAD(P)+), Glutamate Dehydrogenase 1 Mitochondrial, EC 1.4.1, GLUD1.

  • Physical Appearance

    Sterile filtered colorless solution.

  • Stability

    Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Amino Acid Sequence

    MGSSHHHHHH SSGLVPRGSH MGSSEAVADR EDDPNFFKMV EGFFDRGASI VEDKLVEDLR TRESEEQKRN RVRGILRIIK PCNHVLSLSF PIRRDDGSWE VIEGYRAQHS QHRTPCKGGI RYSTDVSVDE VKALASLMTY KCAVVDVPFG GAKAGVKINP KNYTDNELEK ITRRFTMELA KKGFIGPGID VPAPDMSTGE REMSWIADTY ASTIGHYDIN AHACVTGKPI SQGGIHGRIS ATGRGVFHGI ENFINEASYM SILGMTPGFG DKTFVVQGFG NVGLHSMRYL HRFGAKCIAV GESDGSIWNP DGIDPKELED FKLQHGSILG FPKAKPYEGS ILEADCDILI PAASEKQLTK SNAPRVKAKI IAEGANGPTT PEADKIFLER NIMVIPDLYL NAGGVTVSYF EWLKNLNHVS YGRLTFKYER DSNYHLLMSV QESLERKFGK HGGTIPIVPT AEFQDRISGA SEKDIVHSGL AYTMERSARQ IMRTAMKYNL GLDLRTAAYV NAIEKVFKVY NEAGVTFT.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Glud1 Human

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