GLP1R Human

GLP1R Human

GLP

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  • Name :

    GLP1R Human

    Description:

    Glucagon Like Peptide 1 Receptor Human Recombinant

    GLP1, GLP2, GRPP

    Product # :

    HOR-027

    Price :

    Quantity :

    Shipping Method :

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    Shipped at Room temp

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  • formulation
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  • More Info

Description

GLP1R Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (aa 24-145) containing 132 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 15.55 kDa (calculated).

Source

Escherichia Coli.

Formulation

GLP1R filtered (0.4 µm) and lyophilized from 0.5mg/ml in 50mM Acetate Buffer, pH 4.0.

Purity

Greater than 90.0% as determined by SDS-PAGE.

More Info

  • Introduction

    The glucagon-like peptide-1 receptor, also known as GLP1R, is a receptor protein found on brain neurons and beta cells of the pancreas. GLP1R activates a signalling cascade that leads to the initiation of adenylyl cyclase and increased intracellular cAMP levels. In humans, GLP1R is synthesized by GLP1R gene, which is present on chromosome 6.
    GLP1R takes part in the control of blood sugar level by enhancing insulin secretion. GLP1R is a part of the glucagon receptor family of G protein-coupled receptors. GLP1R consists of two domains, one transmembrane (TMD) domain, that binds the N-terminal region of GLP-1. And one extracellular (ECD) which binds the C-terminal helix of GLP-1. The TMD domain contains a fulcrum of polar residues that controls the biased signaling of the receptor, while the transmembrane helical boundaries and extracellular surface are a trigger for biased agonism.

  • Synonyms

    GLP1, GLP2, GRPP

  • Physical Appearance

    Filtered White lyophilized (freeze-dried) powder.

  • Stability

    Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

  • Solubility

    It is recommended to reconstitute the lyophilized Hepatocyte Growth Factor in 100mM Acetate buffer to a working concentration approximately 0.5mg/ml. Further dilutions should be made using buffer containing protein.

  • Amino Acid Sequence

    MKHHHHHHAS RPQGATVSLW ETVQKWREYR RQCQRSLTED PPPATDLFCN RTFDEYACWP DGEPGSFVNV SCPWYLPWAS SVPQGHVYRF CTAEGLWLQK DNSSLPWRDL SECEESKRGE RSSPEEQLLF LY

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Glp1R Human

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