CFD Human

CFD Human

Complement Component

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Description

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  • Name :

    CFD Human

    Description:

    Complement Factor D Human

    Complement factor D, Adipsin, C3 convertase activator, Properdin factor D, CFD, DF, PFD.

    Product # :

    PRO-2699

    Price :

    Quantity :

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  • description
  • source
  • formulation
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  • More Info

Description

Human Complement Factor D produced in Human plasma is glycosylated polypeptide chain having a total molecular mass of 24kDa.

Source

Human Plasma.

Formulation

CFD protein solution contains 10mM Sodium phosphate and 145mM NaCl, pH 7.3.

Purity

Greater than 95.0% as determined by SDS-PAGE.

More Info

  • Introduction

    CFD is an important component of the alternative pathway of complement activation. CFD cleaves and activates factor B when it binds C3b or a C3b-like protein such as C3 or CVF. CFD is a serine protease that exists as a mature protease, but it exhibits a highly restricted specificity and it appears to be substrate activated. CFD cleaves factor B bound to C3b leading to the release of the Ba fragment and leaving the Bb fragment bound to C3b. The C3b,Bb complex is called a C3 or C5 convertase because it converts these proteins to their active forms by cleaving off the small peptides C3a and C5a, respectively.

  • Synonyms

    Complement factor D, Adipsin, C3 convertase activator, Properdin factor D, CFD, DF, PFD.

  • Physical Appearance

    Sterile filtered solution.

  • Stability

    CFD Human is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Human Virus Test

    Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV and HBSAG.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

Cfd Human

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