C4BP Human

C4BP Human

Complement Component

Name

Description

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  • Name :

    C4BP Human

    Description:

    Complement Component 4 Binding Protein Human

    C4bp, C4BP, C4b-binding protein alpha chain, Proline-rich protein, PRP, C4BPA

    Product # :

    PRO-2734

    Price :

    Quantity :

    Shipping Method :

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  • description
  • source
  • formulation
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  • More Info

Description

C4BP Human produced in Human Plasma having a molecular mass of 540 kDa.

Source

Human Plasma.

Formulation

C4BP solution (1mg/ml) contains PBS, pH 7.2.

Purity

Greater than 90% as determined by SDS-PAGE.

More Info

  • Introduction

    C4BP has a flower shaped structure with each alpha chain radiating out from a central core. The arms are linked by disulfide bonds in the centre and the ends of each arm bind C4b. C4BP acts as a cofactor allowing factor I to split and permanently inactivate C4b. C4b binding protein modulates complement activation of the classical and lectin pathways. C4BP binds to C4b and accelerates the dissociation of C2a from the C3/C5 convertase C4b,C2a. This inactivates the central enzyme of both pathways. Studies have shown that on surfaces densely coated with C4b, C4BP can bind up to four C4b molecules simultaneously.

  • Synonyms

    C4bp, C4BP, C4b-binding protein alpha chain, Proline-rich protein, PRP, C4BPA

  • Physical Appearance

    Sterile filtered solution.

  • Stability

    C4BP Human is stable at 4°C if entire vial will be used within 2-4 weeks.Store, frozen below -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

  • Human Virus Test

    Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HTLV-I &II, STS and HBSAG.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

C4Bp Human

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