TBC1 Domain Family

TBC1 Domain Family

TBC1 Domain Family

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  • View Data Sheet

    Description:

    TBC1 Domain Family, Member 13 Human Recombinant

    RP11-545E17.5, TBC1 domain family member 13, Tumor Suppressor Candidate 2, TBC1D13.

    Product # :

    PRO-1679

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    • description
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    Description

    TBC1D13 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 423 amino acids (1-400) and having a molecular mass of 48.9 kDa.TBC1D13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The TBC1D13 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      TBC1 Domain Family, Member 13, also known as TBC1D13, contains 1 Rab-GAP TBC domain. TBC1D13 acts as a GTPase-activating protein for Rab family protein.

    • Synonyms

      RP11-545E17.5, TBC1 domain family member 13, Tumor Suppressor Candidate 2, TBC1D13.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSSLHKS RIADFQDVLK EPSIALEKLR ELSFSGIPCE GGLRCLCWKI LLNYLPLERA SWTSILAKQR ELYAQFLREM IIQPGIAKAN MGVSREDVTF EDHPLNPNPD SRWNTYFKDN EVLLQIDKDV RRLCPDISFF QRATDYPCLL ILDPQNEFET LRKRVEQTTL KSQTVARNRS GVTNMSSPHK NSVPSSLNEY EVLPNGCEAH WEVVERILFI YAKLNPGIAY VQGMNEIVGP LYYTFATDPN SEWKEHAEAD TFFCFTNLMA EIRDNFIKSL DDSQCGITYK MEKVYSTLKD KDVELYLKLQ EQNIKPQFFA FRWLTLLLSQ EFLLPDVIRI WDSLFADDNR FDFLLLVCCA MLMLIREQLL EGDFTVNMRL LQDYPITDVC QILQKAKELQ DSK.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Tbc1D13 Human
  • View Data Sheet

    Description:

    TBC1 Domain Family, Member 1 Human Recombinant

    TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1, KIAA1108, TBC, TBC1, TBC1 Domain Family Member 1.

    Product # :

    PRO-1758

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    Shipping Method :

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    • description
    • source
    • formulation
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    • More Info

    Description

    TBC1D1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids (1-265 a.a) and having a molecular mass of 33.2kDa.TBC1D1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    TBC1D1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      TBC1D1 belongs to a family of proteins sharing a 180-200 a.a TBC domain having a role in regulating cell growth and differentiation of various tissues. These proteins share significant homology with TRE2, yeast Bub2, and CDC16. TBC1D1 function as a GTPase-activating protein for Rab family proteins. TBC1D1 is involved in the trafficking and translocation of GLUT4-containing vesicles. Among the diseases associated with TBC1D1 are tuberculous meningitis, and meningitis.

    • Synonyms

      TBC1 (Tre-2/USP6, BUB2, Cdc16) Domain Family, Member 1, KIAA1108, TBC, TBC1, TBC1 Domain Family Member 1.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSEEEAF KMLKFLMFDM GLRKQYRPDM IILQIQMYQL SRLLHDYHRD LYNHLEEHEI GPSLYAAPWF LTMFASQFPL GFVARVFDMI FLQGTEVIFK VALSLLGSHK PLILQHENLE TIVDFIKSTL PNLGLVQMEK TINQVFEMDI AKQLQAYEVE YHVLQEELID SSPLSDNQRM DKLEKTNSSL RKQNLDLLEQ LQVANGRIQS LEATIEKLLS SESKLKQAML TLELERSALL QTVEELRRRS AEPSDREPEC TQPEPTGD

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Tbc1D1 Human

About TBC1D / TBC1 Domain Family:

TBC1 Domain Family, also known as TBC1D1 is a protein that is founded in humans. It’s the founding member of a family of proteins that all share a 180- to 200-amino acid TBC domain and is associated with cell growth and cell differentiation. It’s also known as TBC, TBC1, and TBC1 domain family member 1

TBC1D Function
TBC1D1 has a specific role in regulating glucose transport through the muscles. In particular, it controls the stimuli-specific upstream signals that then lead to the regulation of glucose transport. Also reported to have a role in fatty acid metabolism, TBC1D1 is thought to be a central regulator of metabolic function in skeletal muscle.

TBC1 Domain Family Mechanism
The specifics of the exact molecular mechanism of TBC1D1 are not fully known at the time of writing, but a commonly accepted suggestion is that it is based on the better-known regulation of the close homolog AS160 (originally known as TBC1 Domain Family Member 4), which provides a mechanism linking AMPK signaling to glucose uptake.

TBC1D Interactions
TBCD1 primarily interacts with the proteins GCG (Glucagon), YWHAB (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta), YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta), YWHAH (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta), and YWHAE (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon), all members of the large 14-3-3 protein family, for which it may act as a GTPase-activating protein.

TBC1 Domain Family Structure
TBC1D1 is localized on chromosome 4p14, and is made up of 20 core exons, 19 of which contain coding sequences that are used to encode for an 1168 consensus amino acid protein.