SRY (Sex Determining Region Y)-Box

SRY (Sex Determining Region Y)-Box

SRY (Sex Determining Region Y)-Box

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  • View Data Sheet

    Description:

    SRY (sex determining region Y)-box 2 Human Recombinant, TAT

    MCOPS3, ANOP3, MGC2413, SOX2, SRY (sex determining region Y)-box 2.

    Product # :

    PRO-1343

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    Shipped at Room temp

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    • description
    • source
    • formulation
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    Description

    Sox2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 330 amino acids (317 aa residues of the full length Sox2) and having a molecular mass of 36kDa.Sox2 is fused to a 13 amino acid TAT peptide at C-terminus (GGYGRKKRRQRRR) & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    Lyophilized from a 0.2µm filtered concentrated solution in 2×PBS, pH 7.4 and 5% trehalose.

    Purity

    Greater than 95.0% as determined by RP-HPLC and SDS-PAGE.

    More Info

    • Introduction

      SOX2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. SOX4 is important for early embryogenesis and for embryonic stem cell pluripotency.

    • Synonyms

      MCOPS3, ANOP3, MGC2413, SOX2, SRY (sex determining region Y)-box 2.

    • Physical Appearance

      Sterile Filtered White lyophilized (freeze-dried) powder.

    • Stability

      Lyophilized Sox2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Sox2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

    • Solubility

      It is recommended to reconstitute the lyophilized Sox2 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

    • Amino Acid Sequence

      MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHMGGY GRKKRRQRRR.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Sox2 Human Tat
  • View Data Sheet

    Description:

    SRY (sex determining region Y)-box 2 Human Recombinant, Polyarginine-Tag

    MCOPS3, ANOP3, MGC2413, SOX2, SRY (sex determining region Y)-box 2.

    Product # :

    PRO-089

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    • description
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    Description

    SOX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 317 amino acids and having a molecular mass of 34.3kDa.The SOX2 is fused to a C-terminal poly-arginine tag and purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The SOX2 solution (0.15mg/ml) contains 20mM PBS.

    Purity

    Greater than 95.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction

      SOX2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. SOX4 is important for early embryogenesis and for embryonic stem cell pluripotency.

    • Synonyms

      MCOPS3, ANOP3, MGC2413, SOX2, SRY (sex determining region Y)-box 2.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      SOX2 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.

    • Amino Acid Sequence

      The sequence of the first five N-terminal amino acids was determined and was found to be Met-Trp-Asn-Met-Met.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Sox2 Human Polyr
  • View Data Sheet

    Description:

    SRY (sex determining region Y)-box 2 Human Recombinant

    MCOPS3, ANOP3, MGC2413, SOX2, SRY (sex determining region Y)-box 2.

    Product # :

    PRO-820

    Price :

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    Shipping Method :

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    • description
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    Description

    SOX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 208 amino acids (1-200 a.a.) and having a molecular mass of 23.1kDa. SOX2 protein is fused to an 8 amino acid His-Tag at C-terminus and purified by standard chromatography.

    Source

    Escherichia Coli.

    Formulation

    The SOX2 solution contains 20mM Tris-HCl pH-8, 2mM DTT, 0.2M NaCl & 40% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      SOX2 is a transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. SOX4 is important for early embryogenesis and for embryonic stem cell pluripotency.

    • Synonyms

      MCOPS3, ANOP3, MGC2413, SOX2, SRY (sex determining region Y)-box 2.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY LEHHHHHH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Sox2 Human

About SOX / SRY (Sex Determining Region Y)-Box:

The SRY (Sex Determining Region Y)-box 2, which is often shorted to SOX2, is a transcription factor that functions to maintain the self-renewal of undifferentiated embryonic stem cells. It has been shown that SOX2 plays an essential function during the maintenance of embryonic and neural stem cells. It belongs to the broader Sox family of transcription factors.

SOX Function
They play a big role in multiple essential stages of the development of mammals. Within the protein family, you’ll find some highly conserved DNA binding domains, which are known as HMG (high-mobility group_ box domains. These contain around 80 amino acids. There is a lot of hope surrounding SOX2 because of the potential it has in the field of regenerative medicines.
This gene is essential for stem-cell maintenance in the central nervous systems. It also helps to regulate gene expression in the stomach. There’s a similar gene in humans that have been associated, when they’re mutated, with optic nerve hypoplasia and syndromic microphthalmia, which is a severe structural eye malformation.

SRY (Sex Determining Region Y)-Box Interactions
In terms of interactions, researchers have found that SOX2 interacts with PAX6, NPM1, and OCT4. There is also evidence that it works in cooperation to regulate things such as Rex1 and Oct3/4. SOX2 plays a big role in lung development and maintenance. If there’s an overexpression, then there could be an increase in intestinal and basal cells. When it works effectively, Sox2 will help to maintain self-renewal and the correct proportion of basal cells, though if there’s an overrepresentation, then problems can arise.