SIX Homeobox

SIX Homeobox

SIX Homeobox

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  • View Data Sheet

    Description:

    SIX Homeobox 6 Human Recombinant

    Homeobox protein SIX6, Homeodomain protein OPTX2, Optic homeobox 2, Sine oculis homeobox homolog 6, SIX6, OPTX2, SIX9, OPTX2, MCOPCT2.

    Product # :

    PRO-1253

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    • description
    • source
    • formulation
    • purity
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    Description

    SIX6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 269 amino acids (1-246 a.a) and having a molecular mass of 30.1kDa.SIX6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    SIX6 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol, 5mM DTT and 2mM EDTA.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      SIX Homeobox 6 (SIX6) is a member of the SIX/Sine oculis homeobox family contains 1 homeobox DNA-binding domain. The SIX6 protein is essential in embryonic development by providing necessary instructions for the formation of the forebrain and eye development. SIX6 is expressed in the developing and adult retina, hypothalamic and the pituitary regions. SIX6 gene defects are the cause of microphthalmia isolated with cataract type 2.

    • Synonyms

      Homeobox protein SIX6, Homeodomain protein OPTX2, Optic homeobox 2, Sine oculis homeobox homolog 6, SIX6, OPTX2, SIX9, OPTX2, MCOPCT2.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMFQLPIL NFSPQQVAGV CETLEESGDV ERLGRFLWSL PVAPAACEAL NKNESVLRAR AIVAFHGGNY RELYHILENH KFTKESHAKL QALWLEAHYQ EAEKLRGRPL GPVDKYRVRK KFPLPRTIWD GEQKTHCFKE RTRNLLREWY LQDPYPNPSK KRELAQATGL TPTQVGNWFK NRRQRDRAAA AKNRLQQQVL SQGSGRALRA EGDGTPEVLG VATSPAASLS SKAATSAISI TSSDSECDI.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Six6 Human
  • View Data Sheet

    Description:

    SIX Homeobox 1 Human Recombinant

    SIX Homeobox 1, Sine Oculis Homeobox Homolog 1, Sine Oculis Homeobox Homolog 1 (Drosophila), Homeobox Protein SIX1, Deafness Autosomal Dominant 23, DFNA23, TIP39, BOS3.

    Product # :

    PRO-1226

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    • description
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    Description

    SIX1 Human Recombinant produced in E. coli is a single polypeptide chain containing 308 amino acids (1-284) and having a molecular mass of 34.7 kDa.SIX1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The SIX1 solution contains 20mM Tris-HCl buffer (pH 8.0), 2M Urea and 10% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      Homeobox protein SIX1 (SIX1) belongs to the SIX gene family. SIX1 is characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which is involved both in determining DNA-binding specificity and in mediating protein-protein interactions. SIX1 has a role in vertebrate and insect development or in the maintenance of the differentiated state of tissues.

    • Synonyms

      SIX Homeobox 1, Sine Oculis Homeobox Homolog 1, Sine Oculis Homeobox Homolog 1 (Drosophila), Homeobox Protein SIX1, Deafness Autosomal Dominant 23, DFNA23, TIP39, BOS3.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMSMLPS FGFTQEQVAC VCEVLQQGGN LERLGRFLWS LPACDHLHKN ESVLKAKAVV AFHRGNFREL YKILESHQFS PHNHPKLQQL WLKAHYVEAE KLRGRPLGAV GKYRVRRKFP LPRTIWDGEE TSYCFKEKSR GVLREWYAHN PYPSPREKRE LAEATGLTTT QVSNWFKNRR QRDRAAEAKE RENTENNNSS SNKQNQLSPL EGGKPLMSSS EEEFSPPQSP DQNSVLLLQG NMGHARSSNY SLPGLTASQP SHGLQTHQHQ LQDSLLGPLT SSLVDLGS

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Six1 Human

About SIX Homeobox:

The six homeobox is encoded in the SIX1 gene. It is a protein family group, one that is found in a wide range of living creatures, from small creatures such as flatworms all the way to humans. They’re fundamentally involved in the development of cell populations that eventually contribute to the creation of key features of the human body, including nose, brain, kidney, and more. There are many different elements to the SIX protein family, with the two most notable being SIX1 and SIX6. If these genes mutate, then they can have serious consequences -- for example, researchers have found that there are elevated levels of SIX genes in certain types of cancer, and it can also be present during tumorigenesis. Most of the interactions with these genes have been identified in insects and flies; researchers have seen how it’s involved in the process of the development of the vertebrae and broader insect development. They also play a role in the maintenance of different types of tissues.

SIX Homeobox Interactions
There are some interactions that researchers have noted, too. They have been shown to interact with EYA1, DACH, GRO, and MDFI, among others. They were able to be noted because of advancements in genome biology technology. Studies have shown that they’re involved in the development of at least forty vertebrates, though the true number will be much greater. There are various binding sites that have been observed in studies; they are controlled by six1 and six6, as well as by other genes, including Slc12a2.