Signal Sequence Receptor

Signal Sequence Receptor

Signal Sequence Receptor

Name

Description

Product #

Price

Quantity

Shipping Method

  • View Data Sheet

    Description:

    Signal Sequence Receptor, Delta Human Recombinant

    TRAPD, Translocon-associated protein subunit delta, TRAP-delta, Signal sequence receptor subunit delta SSR-delta.

    Product # :

    PRO-1294

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add To Cart

    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    SSR4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (24-144 a.a.) and having a molecular mass of 16.1kDa.SSR4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    SSR4 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      SSR4 is a member of the TRAP-delta family. SSR4 is the delta subunit of the translocon-associated protein complex that participates in translocating proteins through the endoplasmic reticulum membrane. SSR4 positioned in the Xq28 region and organized in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene. Both genes are motivated by a CpG-embedded bidirectional promoter.

    • Synonyms

      TRAPD, Translocon-associated protein subunit delta, TRAP-delta, Signal sequence receptor subunit delta SSR-delta.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSEACLEPQ ITPSYYTTSD AVISTETVFI VEISLTCKNR VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG TYEVRFFDEE SYSLLRKAQR NNEDISIIPP LFTVSVDHRG TWNG.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ssr4 Human
  • View Data Sheet

    Description:

    Signal Sequence Receptor, Beta Human Recombinant

    HSD25, TLAP, TRAP-BETA, TRAPB, Translocon-associated protein subunit beta, Signal sequence receptor subunit beta, SSR-beta.

    Product # :

    PRO-1380

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add To Cart

    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    SSR2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 155 amino acids (18-149a.a) and having a molecular mass of 16.8kDa. SSR2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    SSR2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum membrane receptor related with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23. Diseases correlated with SSR2 include calcaneonavicular coalition, and osteosarcoma, and among its related super-pathways are Viral mRNA Translation and Generic Transcription Pathway.

    • Synonyms

      HSD25, TLAP, TRAP-BETA, TRAPB, Translocon-associated protein subunit beta, Signal sequence receptor subunit beta, SSR-beta.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSEEGARLL ASKSLLNRYA VEGRDLTLQY NIYNVGSSAA LDVELSDDSF PPEDFGIVSG MLNVKWDRIA PASNVSHTVV LRPLKAGYFN FTSATITYLA QEDGPVVIGS TSAPGQGGIL AQREFDRRFS PHFLD.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ssr2 Human
  • View Data Sheet

    Description:

    Signal Sequence Receptor, Alpha Human Recombinant

    Signal Sequence Receptor Alpha, Translocon-Associated Protein Alpha, SSR Alpha Subunit, TRAP-alpha, TRAPA.

    Product # :

    PRO-1772

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add To Cart

    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    SSR1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain topological domain containing 209 amino acids (22-207 a.a) and having a molecular mass of 23.1kDa. SSR1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    SSR1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 1mM DTT and 20% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      SSR is a glycosylated endoplasmic reticulum (ER) membrane receptor involved in protein translocation across the ER membrane. SSR is formed of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. SSR gene creates a number of mRNA species due to complex alternative polyadenylation. SSR is unique since it exploits arrays of polyA signal sequences which are mostly non-canonical.

    • Synonyms

      Signal Sequence Receptor Alpha, Translocon-Associated Protein Alpha, SSR Alpha Subunit, TRAP-alpha, TRAPA.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSRGGPRGL LAVAQDLTED EETVEDSIIE DEDDEAEVEE DEPTDLVEDK EEEDVSGEPE ASPSADTTIL FVKGEDFPAN NIVKFLVGFT NKGTEDFIVE SLDASFRYPQ DYQFYIQNFT ALPLNTVVPP QRQATFEYSF IPAEPMGGRP FGLVINLNYK DLNGNVFQDA VFNQTVTVIE REDGLDGET

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ssr1 Human

About SSR / Signal Sequence Receptor:

SSR is a signal sequence receptor protein that belongs to the serine/threonine kinases signal transduction pathway. It can be found in the cytosol of the eukaryotic cell, stabilized by a signal peptide that serves as an import signal for protein translocation into wall-less organelles.

SSR Protein Structure
Within cells, the SSR structure has a small cytoplasmic N Terminal signal sequence followed by four homologous domains (D1–D4), with each domain consisting of two-stranded antiparallel beta-sheets surrounded by eight alpha-helices. The C­ Terminal portion contains a short helical hairpin and five leucines residues; which are involved in dimerization of the SSR protein.

Signal Sequence Receptor Interactions
There are some signal sequence receptor partner proteins, such as signal sequence binding protein 1(SSBP1), signal peptide peptidase (SPP), signal peptide factor 2 (SPF2) and signal recognition particle (SRP). The signal sequence receptor holds a central part in regulating intracellular transport and targeting signals. SSR signal sequence receptor protein-binding proteins can regulate signal blockade and signal recognition.

SSR Function
Signal sequence receptor is one of the key elements in the signal transduction pathway. Signal sequence receptor plays a role in targeting the signal peptide to certain organelles. To recognize and distinguish between intracellular transport signals, signal receptors are needed since intracellular transport sequencer (IDS) or signal peptide transporter (SPT) can't recognize all types of intracellular transport signals

Signal Sequence Receptor Cellular Location
The cytosol of the eukaryotic cell, stabilized by a signal peptide that serves as an import signal for protein translocation into wall-less organelles. signal sequence receptors are composed of a signal peptide, signal recognition particle (SRP), signal sequence binding protein 1(SSBP1) and signal sequence receptor.

SSR Pathway
In the signal pathway, signal receptors bind to substrates with specific intracellular transport signals and control the direction of divergent transport. Signal proteins have a transit peptide at their N terminus that directs them into organelles while targeting proteins typically lack a signal segment. Proteins destined for the nucleus are directed there through interaction with the nuclear localization signal (NLS) in many cases.