Prothymosin

Prothymosin

Prothymosin

Name

Description

Product #

Price

Quantity

Shipping Method

  • View Data Sheet

    Description:

    Prothymosin Human Recombinant

    ParaT, parathymosin.

    Product # :

    PRO-1735

    Price :

    Quantity :

    Shipping Method :

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    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    PTMS Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 125 amino acids (1-102aa) and having a molecular mass of 13.9kDa.PTMS is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PTMS protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Parathymosin, also known as PTMS is a member of the pro/parathymosin family. PTMS may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to particular opportunistic infections. Among the diseases associated with PTMS are hepatitis b, and alzheimer's disease.

    • Synonyms

      ParaT, parathymosin.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSEKSVE AAAELSAKDL KEKKEKVEEK ASRKERKKEV VEEEENGAEE EEEETAEDGE EEDEGEEEDE EEEEEDDEGP ALKRAAEEED EADPKRQKTE NGASA

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ptms Human
  • View Data Sheet

    Description:

    Prothymosin Alpha Human Recombinant

    Prothymosin alpha, TMSA, PTMA, Prothymosin alpha, N-terminally processed, Thymosin alpha-1.

    Product # :

    PRO-1694

    Price :

    Quantity :

    Shipping Method :

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    Shipped with Ice Packs

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    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    PTMA Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 133 amino acids (1-110) and having a molecular mass of 14.5 kDa.PTMA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The PTMA solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Prothymosin alpha (PTMA) is a part of the pro/parathymosin family. PTMA mediates immune function by conferring resistance to some opportunistic infections.

    • Synonyms

      Prothymosin alpha, TMSA, PTMA, Prothymosin alpha, N-terminally processed,
      Thymosin alpha-1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSDAAVD TSSEITTKDL KEKKEVVEEA ENGRDAPANG NANEENGEQE ADNEVDEEEE EGGEEEEEEE EGDGEEEDGD EDEEAESATG KRAAEDDEDD DVDTKKQKTD EDD.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ptma Human

About PTM / Prothymosin:

Prothymosin is a protein that regulates the production of erythropoietin (EPO) in the kidneys. It is responsible for the production and release of EPO. Prothymosin has been extensively studied in animals but not as much in humans. The only study done on humans showed that prothymosin levels were higher during a period of hypoxia than during prolonged normoxia.

PTM Function
Prothymosin alpha helps erythrocytes to mature, which is part of the PTM gene. It is involved in the regulation of the production of hemoglobin and for iron storage in the bone marrow. This protein is mainly found in blood cells and plays an important role in stabilizing the cell membrane. It aids in the synthesis of hemoglobin, DNA, and RNA. In addition, it prevents apoptosis or programmed cell death by stabilizing intracellular proteins.

Prothymosin Interaction
Prothymosin also interacts with tropomyosin. Tropomyosin is an actin-binding protein. This interaction prevents myosin from binding to actin filaments, which aids in the regulation of muscle contraction and relaxation. Proteins that have an interaction with Prothymosin include. Myoglobin, Creatine kinase, Phospholipase A2, and Carbonic anhydrase.

PTM Structure
The structure of prothymosin is made up of two independent chains that are joined by a disulfide bond. The chains are antiparallel and twisted around each other, forming an alpha helix. One chain contains 16 amino acids, while the other has 12 amino acids.

Prothymosin Mechanism
Prothymosin is involved in blood clotting. This protein has two forms, prothymosin alpha, and prothymosin beta. Prothymosin alpha has been found to be a part of the coagulation cascade, which activates the system that leads to clot formation.