Protein C-Ets

Protein C-Ets

Protein C-Ets

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    Description:

    V-Ets Avian Erythroblastosis Virus E26 Oncogene 2 Human Recombinant

    Protein C-ets-2, ETS2, V-Ets Avian Erythroblastosis Virus E26 Oncogene 2, V-ets erythroblastosis virus E26 oncogene homolog 2, ETS2IT1.

    Product # :

    PRO-2007

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    • description
    • source
    • formulation
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    • More Info

    Description

    ETS2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 489 amino acids (1-469 a.a) and having a molecular mass of 55.1kDa. ETS2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    ETS2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      V-Ets Avian Erythroblastosis Virus E26 Oncogene 2 (ETS2) is a transcription factor that regulates genes involved in development and apoptosis. ETS2 is also a protooncogene which takes part in regulation of telomerase. ETS2 protein’s pseudogene is located on the X chromosome.

    • Synonyms

      Protein C-ets-2, ETS2, V-Ets Avian Erythroblastosis Virus E26 Oncogene 2, V-ets erythroblastosis virus E26 oncogene homolog 2, ETS2IT1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MNDFGIKNMD QVAPVANSYR GTLKRQPAFD TFDGSLFAVF PSLNEEQTLQ EVPTGLDSIS HDSANCELPL LTPCSKAVMS QALKATFSGF KKEQRRLGIP KNPWLWSEQQ VCQWLLWATN EFSLVNVNLQ RFGMNGQMLC NLGKERFLEL APDFVGDILW EHLEQMIKEN QEKTEDQYEE NSHLTSVPHW INSNTLGFGT EQAPYGMQTQ NYPKGGLLDS MCPASTPSVL SSEQEFQMFP KSRLSSVSVT YCSVSQDFPG SNLNLLTNNS GTPKDHDSPE NGADSFESSD SLLQSWNSQS SLLDVQRVPS FESFEDDCSQ SLCLNKPTMS FKDYIQERSD PVEQGKPVIP AAVLAGFTGS GPIQLWQFLL ELLSDKSCQS FISWTGDGWE FKLADPDEVA RRWGKRKNKP KMNYEKLSRG LRYYYDKNII HKTSGKRYVY RFVCDLQNLL GFTPEELHAI LGVQPDTED.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Ets2 Human

About ETS2 / Protein C-ETS:

Protein C-ETS2 is a protein in humans that is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.
The ETS2 gene encodes a transcription factor that regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in the regulation of telomerase. A pseudogene of this gene is located on the X chromosome.
ETS2 is implicated in:
●DNA binding
●glucocorticoid receptor binding
●nucleus
●positive regulation of transcription from RNA polymerase II promoter
●positive regulation of transcription, DNA-dependent
●protein binding
●RNA polymerase II regulatory region sequence-specific DNA binding
●sequence-specific DNA binding transcription factor activity
●skeletal system development

ETS2 Interactions
ETS2 has been shown to interact with the following:
●C-jun, a protein encoded by the JUN gene
●Cyclin-dependent kinase 10, an enzyme in humans encoded by the CDK10 gene
●ERG (ETS-related gene), an oncogene that is a member of the ETS (erythroblast transformation-specific) family of transcription factors
●Myb, genes that are a part of a large gene family of transcription factors found in both animals and plants
●ZMYND11 (Zinc finger MYND domain-containing protein 11), a protein in humans encoded by the ZMYND11 gene

Protein C-ETS Functions
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription.
Its molecular functions include DNA binding, sequence-specific DNA binding, RNA polymerase II transcription regulatory region sequence-specific DNA binding, and glucocorticoid receptor binding.