Pim Oncogene

Pim Oncogene

Pim Oncogene

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  • View Data Sheet

    Description:

    PIM2 Human Recombinant

    Pim-2 oncogene, Serine/threonine-protein kinase pim-2, Pim-2h, PIM2.

    Product # :

    PRO-1977

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    • description
    • source
    • formulation
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    Description

    PIM2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 334 amino acids (1-311 a.a) and having a molecular mass of 36.6kDa. PIM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PIM2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 10% glycerol.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      PIM2 is a serine/threonine protein kinase which is a part of the CAMK family. PIM2 is expressed in various tissues mainly in spleen, thymus, testis and small intestine. PIM2 is implicated in tumor phenotypes and participates in the formation and preservation of Long-Term Potentiation (LTP). PIM2 is also involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate.

    • Synonyms

      Pim-2 oncogene, Serine/threonine-protein kinase pim-2, Pim-2h, PIM2.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMLTKPLQ GPPAPPGTPT PPPGGKDREA FEAEYRLGPL LGKGGFGTVF AGHRLTDRLQ VAIKVIPRNR VLGWSPLSDS VTCPLEVALL WKVGAGGGHP GVIRLLDWFE TQEGFMLVLE RPLPAQDLFD YITEKGPLGE GPSRCFFGQV VAAIQHCHSR GVVHRDIKDE NILIDLRRGC AKLIDFGSGA LLHDEPYTDF DGTRVYSPPE WISRHQYHAL PATVWSLGIL LYDMVCGDIP FERDQEILEA ELHFPAHVSP DCCALIRRCL APKPSSRPSL EEILLDPWMQ TPAEDVPLNP SKGGPAPLAW SLLP.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pim2 Human
  • View Data Sheet

    Description:

    PIM1 Human Recombinant

    PIM, Serine/threonine-protein kinase pim-1, PIM1.

    Product # :

    PRO-1389

    Price :

    Quantity :

    Shipping Method :

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    • description
    • source
    • formulation
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    • More Info

    Description

    PIM1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 274 amino acids (38-290 a.a.) and having a molecular mass of 31.4kDa. PIM1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    PIM1 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      PIM1, which is a part of the Ser/Thr protein kinase family and PIM subfamily, is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. PIM1 functions as Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation, consequently providing a selective advantage in tumorigenesis. Both human and orthologous mouse genes have been reported to encode two isoforms resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.

    • Synonyms

      PIM, Serine/threonine-protein kinase pim-1, PIM1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MYQVGPLLGS GGFGSVYSGI RVSDNLPVAI KHVEKDRISD WGELPNGTRV PMEVVLLKKV SSGFSGVIRL LDWFERPDSF VLILERPEPV QDLFDFITER GALQEELARS FFWQVLEAVR HCHNCGVLHR DIKDENILID LNRGELKLID FGSGALLKDT VYTDFDGTRV YSPPEWIRYH RYHGRSAAVW SLGILLYDMV CGDIPFEHDE EIIRGQVFFR QRVSSECQHL IRWCLALRPS DRPTFEEIQN HPWM.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pim1 Human

About PIM / Pim Oncogene:

Pim Oncogene or Pim-1 is a proto-oncogene located on chromosome 6 and has 94-97% amino acid identity. Pim-1 was first discovered in the identification and relation to cancers. It is found to be present in prostate cancer, acute myeloid leukemia and other blood-borne diseases. The gene has also been associated with lung cancer in Korean patients and is more recently found in large cell lymphomas.

PIM Function
Recent scientific progress has been made in understanding the development of Pim signaling and treatment for cancers. Due to the number of oncogenes present, pharmaceuticals are looking to target these types of genes with specific, sensitive drugs with specific toxicity profiles. The inhibitors that can be released by Pim-1 have been discussed as being a treatment that can be used for Alzheimer’s disease which would be a huge breakthrough in treatment options.

Pim Oncogene Mechanism
The presence of Pim-1 is seen excessively in blood deficiencies and illnesses, which is directly linked to higher MYC levels. An elevated number of Pim kinases is seen as a positive potential outcome from individuals with solid cancer, such as prostate cancer, but is seen as a negative potential outcome for others and most blood illnesses. Pim kinases also help to reduce the amount of cell deterioration through signaling. Some studies suggest Pim-1 have negative effects on natural metabolism rates.