PIH1 Domain Containing

PIH1 Domain Containing

PIH1 Domain Containing

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  • View Data Sheet

    Description:

    PIH1 Domain Containing 2 Human Recombinant

    PIH1 Domain Containing 2, PIH1D2.

    Product # :

    PRO-2118

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    • description
    • source
    • formulation
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    Description

    PIH1D2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 338 amino acids (1-315 a.a) and having a molecular mass of 38.3kDa.PIH1D2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PIH1D2 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      PIH1 Domain Containing 2, also known as PIH1D2 is a member of the PIH1 family.PIH1D2 was present in the common ancestor of chordates. There are 45 Species with no ortholog for PIH1D2. In addition, no disorders were found for PIH1D2 Gene.

    • Synonyms

      PIH1 Domain Containing 2, PIH1D2.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMETSSKG LLTQVTQFWN LLDDLAQSDP EGYEKFIQQQ LKEGKQLCAA PEPQLCLQTR ILKPKEKILF INLCQWTRIP APQSTTHPVP LTVGKPEDTT EISDAYTVID VAYNPDVLHA AEKDQVKKNQ LIQMAMKCIE EKFQFTLSHS YHITKFRIKG SIQRMKQNLM GIQTDSIDLR EKMRRELTLG QIRSSTMSNP DHFPQLLLPK DQVSGKAVCL IEEISSTEIQ VEMKMPAYEL KIVHDHSEKP LKIELKVELP GINSVSLCDL SVSEDDLLIE VSEKYRLHLN LPKLIDTEMT TAKFIKEKST LIITMPLV.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pih1D2 Human
  • View Data Sheet

    Description:

    PIH1 Domain Containing 1 Human Recombinant

    NOP17, Nucleolar Protein 17 Homolog, PIH1 Domain-Containing Protein 1, PIH1 Domain-Containing 1, PIH1D1.

    Product # :

    PRO-1753

    Price :

    Quantity :

    Shipping Method :

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    Shipped with Ice Packs

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    More Info

    • description
    • source
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    • More Info

    Description

    PIH1D1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 313 amino acids (1-290a.a) and having a molecular mass of 34.8kDa. PIH1D1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PIH1D1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      PIH1 domain-containing protein 1 (PIH1D1) is a member of the PIH1 family. PIH1D1 is a phylogenetically conserved protein vital for efficient processing of pre-rRNA through its association along with a class of small nucleolar RNAs (snoRNAs) during ribosomal biogenesis. SnoRNAs are linked in ribonucleoprotein particles localized to the nucleolus. PIH1D1 may also act as a novel modulator of apoptosis pathway.

    • Synonyms

      NOP17, Nucleolar Protein 17 Homolog, PIH1 Domain-Containing Protein 1, PIH1 Domain-Containing 1, PIH1D1.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMANPKLL GMGLSEAEAI GADSARFEEL LLQASKELQQ AQTTRPESTQ IQPQPGFCIK TNSSEGKVFI NICHSPSIPP PADVTEEELL QMLEEDQAGF RIPMSLGEPH AELDAKGQGC TAYDVAVNSD FYRRMQNSDF LRELVITIAR EGLEDKYNLQ LNPEWRMMKN RPFMGSISQQ NIRSEQRPRI QELGDLYTPA PGRAESGPEK PHLNLWLEAP DLLLAEVDLP KLDGALGLSL EIGENRLVMG GPQQLYHLDA YIPLQINSHE SKAAFHRKRK QLMVAMPLLP VPS

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pih1D1 Human

About PIH1D / PIH1 Domain Containing:

PIH1 Domain Containing 1 or PIH1 is found within genetics as being involved with protein-coding and the assembly of C/D box small nucleolar ribonucleoprotein particles. It is a component of the R2TP complex with interacts with Hsp90 to create large complex protein structures. PIH1 Domain is made from different structures including Kintoun. Kintoun is needed for the prior assembly of axonemal dyneins.

PIH1 Domain Components
-Part of R2TP complex
-Active in the cytoplasm
-Located in the cytoplasm
-Located in the nucleolus
-Part of the pre-snoRNP complex
-Part of the ribonucleoprotein complex

PIH1D Homology
-Geneology is found in chimpanzees, Rhesus monkeys, dogs, cows, mice, rats, zebrafish, fruit flies, frogs and homo sapiens.
-294 organisms have been shown to have similarities with the human gene P1H1D1

PIH1 Domain Containing Function
-Enables ATPase binding
-Enables RNA polymerase I core promoter sequence-specific DNA binding
-Enables histone binding
-Enables phosphoprotein binding
-Enables protein binding
-Enables protein kinase binding

PIH1D Process
-Involved in the creation of RNA polymerase I preinitiation complex
-Involved in the creation of box C/D snoRNP
-Involved in the remaking and remodelling of chromatin
-Involved in being able to differentiate epithelial cells
-Involved in the establishment of protein localization to chromatin
-Involved in negative regulation of cysteine-type endopeptidase activity
-Involved in apoptotic signalling pathways
-Involved in negative regulation of specific histones
-Involved in the positive regulation of hormone and cell signalling and communication