PDZ Domain Containing

PDZ Domain Containing

PDZ Domain Containing

Name

Description

Product #

Price

Quantity

Shipping Method

  • View Data Sheet

    Description:

    PDZ Domain Containing 1 Human Recombinant

    PDZ Domain Containing 1, PDZ-Containing Kidney Protein 1, Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3, Na/Pi Cotransporter C-Terminal-Associated Protein 1, Sodium-Hydrogen Exchanger Regulatory Factor 3, CFTR-Associated Protein Of 70 KDa, NHERF-3, CAP70, PDZD1, CLAMP, naPi-Cap1.

    Product # :

    PRO-1447

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add To Cart

    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    PDZK1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 542 amino acids (1-519 a.a.) and having a molecular mass of 59.0kDa.PDZK1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    PDZK1 protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      PDZK1 is a PDZ domain-containing scaffolding protein which facilitates localization of cell surface proteins and has a key part in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphism in this gene is linked to metabolic syndrome, and overexpression results in drug resistance of multiple myeloma.

    • Synonyms

      PDZ Domain Containing 1, PDZ-Containing Kidney Protein 1, Na(+)/H(+) Exchange Regulatory Cofactor NHE-RF3, Na/Pi Cotransporter C-Terminal-Associated Protein 1, Sodium-Hydrogen Exchanger Regulatory Factor 3, CFTR-Associated Protein Of 70 KDa, NHERF-3, CAP70, PDZD1, CLAMP, naPi-Cap1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMTSTFNP RECKLSKQEG QNYGFFLRIE KDTEGHLVRV VEKCSPAEKA GLQDGDRVLR INGVFVDKEE HMQVVDLVRK SGNSVTLLVL DGDSYEKAVK TRVDLKELGQ SQKEQGLSDN ILSPVMNGGV QTWTQPRLCY LVKEGGSYGF SLKTVQGKKG VYMTDITPQG VAMRAGVLAD DHLIEVNGEN VEDASHEEVV EKVKKSGSRV MFLLVDKETD KRHVEQKIQF KRETASLKLL PHQPRIVEMK KGSNGYGFYL RAGSEQKGQI IKDIDSGSPA EEAGLKNNDL VVAVNGESVE TLDHDSVVEM IRKGGDQTSL LVVDKETDNM YRLAHFSPFL YYQSQELPNG SVKEAPAPTP TSLEVSSPPD TTEEVDHKPK LCRLAKGENG YGFHLNAIRG LPGSFIKEVQ KGGPADLAGL EDEDVIIEVN GVNVLDEPYE KVVDRIQSSG KNVTLLVCGK KAYDYFQAKK IPIVSSLADP LDTPPDSKEG IVVESNHDSH MAKERAHSTA SHSSSNSEDT EM

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pdzk1 Human
  • View Data Sheet

    Description:

    PDZ Domain Containing 11 Human Recombinant

    PDZ domain-containing protein 11, ATPase-interacting PDZ protein, Plasma membrane calcium ATPase-interacting single-PDZ protein, PMCA-interacting single-PDZ protein, PDZD11, AIPP1, PDZK11, PISP.

    Product # :

    PRO-1263

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add To Cart

    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    PDZD11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 163 amino acids (1-140 a.a) and having a molecular mass of 18.5kDa.PDZD11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PDZD11 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      PDZ Domain Containing 11 (PDZD11) is a cytosolic protein which contains one PDZ (DHR) domain. PDZD11 displays a resemblance to members of the MALS / VELIS family of proteins. PDZD11 contains but one PDZ domain which seemingly interacts with the C-terminus of partner proteins. PDZD11 is ubiquitously expressed and targets calcium and copper ATPases to basolateral cell membranes. PDZD11 is a briefly interacting partner of the PMCA b-splice forms which have a role in their sorting to or from the plasma membrane.

    • Synonyms

      PDZ domain-containing protein 11, ATPase-interacting PDZ protein, Plasma membrane calcium ATPase-interacting single-PDZ protein, PMCA-interacting single-PDZ protein, PDZD11, AIPP1, PDZK11, PISP.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMDSRIPY DDYPVVFLPA YENPPAWIPP HERVHHPDYN NELTQFLPRT ITLKKPPGAQ LGFNIRGGKA SQLGIFISKV IPDSDAHRAG LQEGDQVLAV NDVDFQDIEH SKAVEILKTA REISMRVRFF PYNYHRQKER TVH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pdzd11 Human

About PDZ Domain Containing:

PDZ domain is a structure of amino acids that are found in bacteria, yeast and animals among others. These PDZ domains are crucially needed for cell-cell communication. PDZ domains are found in all living animals in differing quantities. In mice, for example, 928 PDZ domains have been discovered, which in comparison to humans is a relatively small number. Research into PDZ domains can give much needed and important insights into relatively unknown biological processes. PDZ scaffold proteins exist at molecular levels and are impertinent for controlling cell-cell signaling at any space and time.

PDZ Domain Containing Function
PDZ domains are specifically and carefully created to be encoded for specific responses, these responses are reported to change over time to work directly for lipid scaffolding.

PDZ Domain Containing Mechanism
These domains are aware of short C-terminal peptide motifs and can also understand the internal sequences of a terminus. Therefore, these types of domains can be used to bind target proteins or to branch into several different networks. Binding is shown to be a slow process, however remains to have a high level of strength when connecting to other lipids. The PDZ domain is found within signaling proteins which are important within the role of supramolecular signaling complexes. There is working thought that PDZ domains are in abundance, with each strain resulting in direct cellular processing and signaling for specific reasoning.
Scientific belief is that PDZ domains have evolved to support the increasing signaling requirements of all multicellular organisms. Opening a pathway to new scientific discoveries and findings.