Parkinson Disease Protein

Parkinson Disease Protein

Parkinson Disease Protein

Name

Description

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  • View Data Sheet

    Description:

    Parkinson Disease Protein 7 Mouse Recombinant

    Protein deglycase DJ-1, Parkinson disease protein 7 homolog.

    Product # :

    PRO-2226

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    Description

    PARK7 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-189 a.a) and having a molecular mass of 22.4kDa. PARK7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PARK7 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      The PARK7 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the PARK7 are the cause of autosomal recessive early-onset Parkinson’s disease 7 (Park7).

    • Synonyms

      Protein deglycase DJ-1, Parkinson disease protein 7 homolog.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMASKRAL VILAKGAEEM ETVIPVDVMR RAGIKVTVAG LAGKDPVQCS RDVMICPDTS LEDAKTQGPY DVVVLPGGNL GAQNLSESPM VKEILKEQES RKGLIAAICA GPTALLAHEV GFGCKVTTHP LAKDKMMNGS HYSYSESRVE KDGLILTSRG PGTSFEFALA IVEALVGKDM ANQVKAPLVL KD.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Park7 Mouse
  • View Data Sheet

    Description:

    Parkinson Disease Protein 7 Human Recombinant

    Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7, DJ1, DJ-1, FLJ27376.

    Product # :

    PRO-575

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    Description

    PARK7 Human Recombinant fused to an N-terminal 36 aa His-Tag, produced in E.Coli is a single, non-glycosylated polypeptide chain (aa 1-189) containing 225 amino acids and having a molecular mass of 24 kDa.

    Source

    Escherichia Coli.

    Formulation

    The protein solution (1mg/ml) contains 20mM Tris-HCl pH-8 and 20% glycerol.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      The PARK7 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the PARK7 are the cause of autosomal recessive early-onset Parkinson’s disease 7 (Park7).

    • Synonyms

      Protein DJ-1, Oncogene DJ1, Parkinson disease protein 7, PARK7, DJ1, DJ-1, FLJ27376.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMASK RALVILAKGA EEMETVIPVD VMRRAGIKVT VAGLAGKDPV QCSRDVVICP DASLEDAKKE GPYDVVVLPG GNLGAQNLSE SAAVKEILKE QENRKGLIAA ICAGPTALLA HEIGFGSKVT THPLAKDKMM NGGHYTYSEN RVEKDGLILT SRGPGTSFEF ALAIVEALNG KEVAAQVKAP LVLKD.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Park7 Human
  • View Data Sheet

    Description:

    Parkinson Disease Protein 2 Human Recombinant

    Parkin RBR E3 Ubiquitin Protein Ligase, Parkinson Juvenile Disease Protein 2, Parkinson Protein 2 E3 Ubiquitin Protein Ligase (Parkin), Parkinson Disease (Autosomal Recessive, Juvenile) 2 Parkin, PRKN, AR-JP, PDJ, E3 Ubiquitin Ligase, LPRS2, EC 6.3.2.-.

    Product # :

    PRO-1840

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    Description

    PARK2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 485 amino acids (1-465) and having a molecular mass of 53.8 kDa. PARK2 is fused to a 20 amino acid His-tag at N-terminus.

    Source

    Escherichia Coli.

    Formulation

    The PARK2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 80% as determined by SDS-PAGE.

    More Info

    • Introduction

      PARK2 is an element in a multiprotein E3 ubiquitin ligase complex which mediates the targeting of substrate proteins for proteasomal degradation. PARK2 alterations can result in Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing creates multiple transcript variants encoding distinct isoforms.

    • Synonyms

      Parkin RBR E3 Ubiquitin Protein Ligase, Parkinson Juvenile Disease Protein 2, Parkinson Protein 2 E3 Ubiquitin Protein Ligase (Parkin), Parkinson Disease (Autosomal Recessive, Juvenile) 2 Parkin, PRKN, AR-JP, PDJ, E3 Ubiquitin Ligase, LPRS2, EC 6.3.2.-.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA VILHTDSRKD SPPAGSPAGR SIYNSFYVYC KGPCQRVQPG KLRVQCSTCR QATLTLTQGP SCWDDVLIPN RMSGECQSPH CPGTSAEFFF KCGAHPTSDK ETSVALHLIA TNSRNITCIT CTDVRSPVLV FQCNSRHVIC LDCFHLYCVT RLNDRQFVHD PQLGYSLPCV AGCPNSLIKE LHHFRILGEE QYNRYQQYGA EECVLQMGGV LCPRPGCGAG LLPEPDQRKV TCEGGNGLGC GFAFCRECKE AYHEGECSAV FEASGTTTQA YRVDERAAEQ ARWEAASKET IKKTTKPCPR CHVPVEKNGG CMHMKCPQPQ CRLEWCWNCG CEWNRVCMGD HWFDV

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Park2 Human


About PARK / Parkinson Disease Protein:

Parkinson's disease is a progressive neurodegenerative disorder that affects the motor system. Symptoms include:
●Tremors
●Rigidity and
●Difficulty walking
Parkinson's Disease Protein (Park) has been in the brains of those with Parkinson's disease and people without any symptoms at all.
Parkinson's Disease Protein (Park) has many functions, but there are currently no treatments or cures. More research can find out how these proteins work and develop treatment options. Hopefully, this will lead to a better understanding of Park and provide more knowledge on how this protein functions to develop treatments.


PARK Mechanism
Parkinson's Disease Protein (Park) is a protein located in the mitochondria. It is associated with oxidative stress, leading to Parkinson's disease and other neurodegenerative disorders such as Alzheimer's and Huntington's diseases.

Parkinson Disease Protein Interactions
Parkinson's Disease Protein (Park) interacts with numerous proteins. One of these is TREM-like protein, which decreases the amount of Park present in cells and causes Parkinson's Disease symptoms.

PARK Treatment
There is currently no treatment for Parkinson's Disease Protein (Park).

Parkinson Disease Protein Structure
The structure of Parkinson's Disease Protein (Park) is that it has a globular-like shape.

Research on Park
Numerous research studies are ongoing to find treatments for Parkinson's Disease and other neurodegenerative diseases. In the future, there may be more knowledge about how these proteins work to develop treatments for them.

Parkinson Disease Protein Functions
Parkinson's Disease Protein (Park) has many functions. One of them is the production and regulation of dopamine.
One study found that Parkinson's patients without Park proteins had lower synapses than those with an average protein level. Another function is autophagy, which helps to get rid of cellular waste products.