Paired Box

Paired Box

Paired Box

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    Description:

    Paired Box 9 Human Recombinant

    Paired Box 9, STHAG3, Paired Box Gene 9, Paired Box Protein Pax-9, Paired Domain Gene 9.

    Product # :

    PRO-1724

    Price :

    Quantity :

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    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    PAX9 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 364 amino acids (1-341 a.a) and having a molecular mass of 38.7kDa.PAX9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PAX9 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      PAX9 (Paired box protein Pax-9) belongs to the paired box (PAX) family of transcription factors. Members of PAX9 family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. In addition, PAX9 is vital for the development of different organs and skeletal elements.

    • Synonyms

      Paired Box 9, STHAG3, Paired Box Gene 9, Paired Box Protein Pax-9, Paired Domain Gene 9.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMEPAFGE VNQLGGVFVN GRPLPNAIRL RIVELAQLGI RPCDISRQLR VSHGCVSKIL ARYNETGSIL PGAIGGSKPR VTTPTVVKHI RTYKQRDPGI FAWEIRDRLL ADGVCDKYNV PSVSSISRIL RNKIGNLAQQ GHYDSYKQHQ PTPQPALPYN HIYSYPSPIT AAAAKVPTPP GVPAIPGSVA MPRTWPSSHS VTDILGIRSI TDQVSDSSPY HSPKVEEWSS LGRNNFPAAA PHAVNGLEKG ALEQEAKYGQ APNGLPAVGS FVSASSMAPY PTPAQVSPYM TYSAAPSGYV AGHGWQHAGG TSLSPHNCDI PASLAFKGMQ AAREGSHSVT ASAL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pax9 Human
  • View Data Sheet

    Description:

    Paired Box 8 Human Recombinant

    Paired Box 8, Paired Box Gene 8, PAX8.

    Product # :

    PRO-2134

    Price :

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    Shipping Method :

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    • description
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    Description

    PAX8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 310 amino acids (1-287 a.a) and having a molecular mass of 33.4kDa.PAX8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    PAX8 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Paired box 8, also known as PAX8 functions in thyroid follicular cell development as well as in expression of thyroid-specific genes. PAX8 complexes with TTF-1& TTF-2 in order to stimulate thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of NIS (sodium iodide symporter) , TPO (thyroid peroxidase), TG (thyroglobulin) and the TSHR (thyrotropin receptor). Defects in PAX8 are the cause of CHNG2 (congenital hypothyroidism non-goitrous type 2).

    • Synonyms

      Paired Box 8, Paired Box Gene 8, PAX8.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMPHNSIR SGHGGLNQLG GAFVNGRPLP EVVRQRIVDL AHQGVRPCDI SRQLRVSHGC VSKILGRYYE TGSIRPGVIG GSKPKVATPK VVEKIGDYKR QNPTMFAWEI RDRLLAEGVC DNDTVPSVSS INRIIRTKVQ QPFNLPMDSC VATKSLSPGH TLIPSSAVTP PESPQSDSLG STYSINGLLG IAQPGSDKRK MDDSDQDSCR LSIDSQSSSS GPRKHLRTDA FSQHHLEPLE CPFERQHYPE AYASPSHTKG EQEVNTLAMP MATPPTPPTA RPGASPTPAC

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Pax8 Human

About Pax / Paired Box Protein:

Paired Box Protein (Pax) is a gene that plays a vital role in regulating cell growth, differentiation, and proliferation. Pax proteins are in all animal cells, including human cells.
The function of this protein is not yet fully understood, but it is involved in many cellular processes such as:
●DNA replication
●Transcriptional regulation
●Apoptosis.
The power of Pax has undergone testing in several clinical trials, and it is safe for use by most adults. It has also helped children with autism learn, communicate better, and even play more effectively than before! Use this article to learn more about this type of protein.

Pax Mechanism
Pax proteins are transcriptional activators that bind to DNA and regulate gene expression. These protein sequences have a paired-box motif in the amino acid sequence that binds to specific sites on the DNA.
This binding leads to changes in chromatin structure, which can activate or repress genes at these locations. Thus, Pax has also been involved in a wide range of cellular processes and can probably have tumor suppressor activity.

Paired Box Protein Interactions
The Pax genes are in animal cells, and the proteins play a role in many cellular processes. Again, the function of these proteins is not yet fully understood, but they are involved in DNA replication, regulation of transcription, apoptosis, and other parts.
Pax also interacts with other proteins such as E47, a transcription factor that is important in the later stages of embryonic development and cell differentiation.

Pax Structure
Pax proteins have a paired-box motif that binds to specific sites on the DNA. This binding leads to changes in chromatin structure and can activate or repress genes at these locations.