Orosomucoid

Orosomucoid

Orosomucoid

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  • View Data Sheet

    Description:

    Orosomucoid 1 Human Recombinant, HEK

    Orosomucoid 1, ORM, AGP1, OMD 1, AGP-A, alpha-1-acid glycoprotein 1.

    Product # :

    PRO-2764

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    Description

    ORM1 Human Recombinant produced in HEK is a polypeptide chain containing 189 amino acids (19-201) and having a molecular mass of 22.4 kDa. The ORM1 is fused to a 6 a.a. amino acid His tag at C-terminus & purified by proprietary chromatographic techniques.

    Source

    HEK293

    Formulation

    The ORM1 solution (1mg/ml) contains 1x PBS pH-7 and 10% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

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    • Introduction

      The acute phase plasma protein ORM1 synthesized by the liver mediates the interaction between blood cells and endothelial cells. In addition, together with haptoglobin and C reactive protein, ORM1 regulates the extravasation of the cells through infection and inflammation. Expression of ORM1 is induced by acute-phase stimulatory mediators such as bacterial lipopolysaccharides.

    • Synonyms

      Orosomucoid 1, ORM, AGP1, OMD 1, AGP-A, alpha-1-acid glycoprotein 1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      QIPLCANLVP VPITNATLDR ITGKWFYIAS AFRNEEYNKS VQEIQATFFY FTPNKTEDTI FLREYQTRQD QCIYNTTYLN VQRENGTISR YVGGQEHFAH LLILRDTKTY MLAFDVNDEK NWGLSVYADK PETTKEQLGE FYEALDCLRI PKSDVVYTDW KKDKCEPLEK QHEKERKQEE GES HHHHHH

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Orm1 Protein
  • View Data Sheet

    Name :

    ORM1

    Description:

    Orosomucoid 1 Human Recombinant

    Orosomucoid 1, ORM, AGP1, OMD 1, AGP-A, alpha-1-acid glycoprotein 1.

    Product # :

    PRO-889

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    Description

    ORM1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 184 amino acids (19-201) and having a molecular mass of 21.7 kDa.The ORM1 is purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The ORM1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 5% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      The acute phase plasma protein ORM1 synthesized by the liver mediates the interaction between blood cells and endothelial cells. In addition, together with haptoglobin and C reactive protein, ORM1 regulates the extravasation of the cells through infection and inflammation. Expression of ORM1 is induced by acute-phase stimulatory mediators such as bacterial lipopolysaccharides.

    • Synonyms

      Orosomucoid 1, ORM, AGP1, OMD 1, AGP-A, alpha-1-acid glycoprotein 1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MQIPLCANLV PVPITNATLD QITGKWFYIA SAFRNEEYNK SVQEIQATFF YFTPNKTEDT IFLREYQTRQ DQCIYNTTYL NVQRENGTIS RYVGGQEHFA HLLILRDTKT YMLAFDVNDE KNWGLSVYAD KPETTKEQLG EFYEALDCLR IPKSDVVYTD WKKDKCEPLE KQHEKERKQE EGES.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Orm1 Human
  • View Data Sheet

    Description:

    Orosomucoid 2 Human Recombinant, sf9

    Orosomucoid 2, Alpha-1-Acid Glycoprotein Type 2, OMD 2, AGP2, AGP-B, Type 2,ORM2.

    Product # :

    PRO-2402

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    Description

    ORM2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 192 amino acids (19-201) and having a molecular mass of 22.7kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). ORM2 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

    Source

    Sf9, Baculovirus cells.

    Formulation

    ORM2 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

    Purity

    Greater than 90.0% as determined by analysis by SDS-PAGE.

    More Info

    • Introduction

      ORM2 is a significant acute phase plasma protein. ORM2 is highly expressed as a result of acute inflammation there for it is categorized as an acute-phase reactant.

    • Synonyms

      Orosomucoid 2, Alpha-1-Acid Glycoprotein Type 2, OMD 2, AGP2, AGP-B, Type 2,
      ORM2.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      ADPQIPLCAN LVPVPITNAT LDRITGKWFY IASAFRNEEY NKSVQEIQAT FFYFTPNKTE DTIFLREYQT RQNQCFYNSS YLNVQRENGT VSRYEGGREH VAHLLFLRDT KTLMFGSYLD DEKNWGLSFY ADKPETTKEQ LGEFYEALDC LCIPRSDVMY TDWKKDKCEP LEKQHEKERK QEEGESHHHH HH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Orm2 Human Sf9
  • View Data Sheet

    Description:

    Orosomucoid 2 Human Recombinant

    Orosomucoid 2, Alpha-1-Acid Glycoprotein Type 2, OMD 2, AGP2, AGP-B, Type 2.

    Product # :

    PRO-1560

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    Description

    ORM2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 208 amino acids (19-201) and having a molecular mass of 24.3kDa.ORM2 is fused to a 25 amino acid His-tag at N-terminus.

    Source

    Escherichia Coli.

    Formulation

    The ORM2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 95% as determined by SDS-PAGE.

    More Info

    • Introduction

      ORM2 is a significant acute phase plasma protein. ORM2 is highly expressed as a result of acute inflammation there for it is categorized as an acute-phase reactant.

    • Synonyms

      Orosomucoid 2, Alpha-1-Acid Glycoprotein Type 2, OMD 2, AGP2, AGP-B, Type 2.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMQIPLC ANLVPVPITN ATLDRITGKW FYIASAFRNE EYNKSVQEIQ ATFFYFTPNK TEDTIFLREY QTRQNQCFYN SSYLNVQREN GTVSRYEGGR EHVAHLLFLR DTKTLMFGSY LDDEKNWGLS FYADKPETTK EQLGEFYEAL DCLCIPRSDV MYTDWKKDKC EPLEKQHEKE RKQEEGES.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Orm2 Human
  • View Data Sheet

    Description:

    Orosomucoid 1 Human

    Orosomucoid 1, ORM, AGP1, OMD 1, AGP-A, alpha-1-acid glycoprotein 1, ORM1.

    Product # :

    PRO-1570

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    Description

    The Human Orosomucoid 1 produced from Human pooled serum has a molecular mass of 21.56kDa (calculated without glycosylation) containing 183 amino acid residues.

    Source

    Human pooled serum.

    Formulation

    ORM1 protein filtered (0.4µm) and lyophilized in 0.5 mg/ml in 20mM TRIS and 50mM NaCl, pH 7.5.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      The acute phase plasma protein ORM1 synthesized by the liver mediates the interaction between blood cells and endothelial cells. In addition, together with haptoglobin and C reactive protein, ORM1 regulates the extravasation of the cells through infection and inflammation. Expression of ORM1 is induced by acute-phase stimulatory mediators such as bacterial lipopolysaccharides.

    • Synonyms

      Orosomucoid 1, ORM, AGP1, OMD 1, AGP-A, alpha-1-acid glycoprotein 1, ORM1.

    • Physical Appearance

      Filtered White lyophilized (freeze-dried) powder.

    • Stability

      Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

    • Solubility

      It is recommended to add deionized water to prepare a working stock solution of approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

    • Amino Acid Sequence

      QIPLCANLVP VPITNATLDQ ITGKWFYIAS AFRNEEYNKS VQEIQATFFY FTPNKTEDTI FLREYQTRQD QCIYNTTYLN VQRENGTISR YVGGQEHFAH LLILRDTKTY MLAFDVNDEK NWGLSVYADK PETTKEQLGE FYEALDCLRI PKSDVVYTDW KKDKCEPLEK QHEKERKQEE GES.

    • Human Virus Test

      Blood samples from each donor have been tested and found negative for HBsAg, anti-HCV, HIV Ag/Ab, and syphilis.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Human Orm1

About ORM / Orosomucoid:

Orosomucoid Mechanism
Orosomucoid, also known as alpha-1-acid glycoprotein (AGP), was first reported in 1950. It is an acute-phase protein produced in the liver as well as in extrahepatic sites. Due to acute inflammation, it can cause the plasma concentrations of ORM levels to rapidly increase in response. Plasma levels are affected by burns, certain drugs, pregnancy, HIV, and other certain diseases.

ORM Interactions
Orosomucoid-related receptors have been initially explored in liver parenchymal cells, macrophages, and neutrophils. Respectively involving the membrane septro CCR5, HBB and Siglec-5. ORM can act as a disease marker, carry and bind drugs, modulate immunity, mediating the sphingolipid metabolism, and maintain the carrier function of the capillary.

Orosomucoid Function
Because there is not a concrete known function for orosomucoid, it is of the opinion that orosomucoid (ORM) regulates the immune system in the acute-phase reaction. It's also suggested that ORM is part of a negative feedback system. The production of ORM by leukocytes can be stimulated by inflammatory cytokines (like interleukin 1 and tumor necrosis factor-a).

ORM Structure
Orosomucoid (ORM) is part of the acute-phase proteins. It is heavily glycosylated at 45% with a molecular weight of 37-54 kDa and a low pl of 2.8-3.8. The liver is the primary production of ORM. But under various physiological and pathological conditions, it was reported that many extrahepatic tissues can produce ORM. A combination of the significant regulator go-between, like IL-6, IL-1, glucocorticoids, and TNF-a, can control aspects of the ORM gene.