NPM

NPM

NPM

Name

Description

Product #

Price

Quantity

Shipping Method

  • View Data Sheet

    Description:

    Nucleophosmin 2 Human Recombinant

    Nucleophosmin/nucleoplasmin 2, nucleoplasmin-2.

    Product # :

    PRO-1182

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    • description
    • source
    • formulation
    • purity
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    Description

    NPM2 Human Recombinant produced in E. coli is a single polypeptide chain containing 237 amino acids (1-214) and having a molecular mass of 26.6 kDa.NPM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The NPM2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 200mM NaCl, 2mM DTT and 20% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      NPM2 is a member of nucleoplasmin family. NPM2 is a core histones chaperone which takes part in chromatin reprogramming, particularly throughout fertilization and early embryonic development. NPM2 also takes part in sperm DNA decondensation during fertilization.

    • Synonyms

      Nucleophosmin/nucleoplasmin 2, nucleoplasmin-2.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMNLSSAS STEEKAVTTV LWGCELSQER RTWTFRPQLE GKQSCRLLLH TICLGEKAKE EMHRVEILPP ANQEDKKMQP VTIASLQASV LPMVSMVGVQ LSPPVTFQLR AGSGPVFLSG QERYEASDLT WEEEEEEEGE EEEEEEEDDE DEDADISLEE
      QSPVKQVKRL VPQKQASVAK KKKLEKEEEE IRASVRDKSP VKKAKATARA KKPGFKK

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Npm2 Human
  • View Data Sheet

    Description:

    Nucleophosmin Human Recombinant

    Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM, B23.

    Product # :

    PRO-1120

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    Description

    NPM1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 314 amino acids (1-294 a.a) and having a molecular mass of 34.7kDa.NPM1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    NPM1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.15M NaCl and 1mM DTT.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Nucleophosmin (NPM1) is a phosphoprotein which shuffles between the nucleus and the cytoplasm. NPM1 is assumed to be involved in a number of processes including regulation of the ARF/p53 pathway. Several genes fusion partners have been described, particularly the anaplastic lymphoma kinase gene on chromosome 2. NPM1 gene mutations are linked with acute myeloid leukemia.

    • Synonyms

      Nucleophosmin, NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, NPM1, NPM, B23.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MEDSMDMDMS PLRPQNYLFG CELKADKDYH FKVDNDENEH QLSLRTVSLG AGAKDELHIV EAEAMNYEGS PIKVTLATLK MSVQPTVSLG GFEITPPVVL RLKCGSGPVH ISGQHLVAVE EDAESEDEEE EDVKLLSISG KRSAPGGGSK VPQKKVKLAA
      DEDDDDDDEE DDDEDDDDDD FDDEEAEEKA PVKKSIRDTP AKNAQKSNQN GKDSKPSSTP RSKGQESFKK QEKTPKTPKG PSSVEDIKAK MQASIEKGGS LPKVEAKFIN YVKNCFRMTD QEAIQDLWQW RKSL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Npm1 Human

About NPM / Nucleophosmin:

Nucleophosmin (NPM1), which you may see written as B23, No38, or Numatrin, is a protein present in the nuclei of proliferating cells that is abundant in the nuclei. NPM1 has been linked to ribosome biogenesis, mRNA processing, chromatin remodelling, and embryogenesis. While much is known about NPM1's role in metabolic pathways, it is more and more evident that NPM1 also plays an important role in genomic stability by participating in multiple DNA repair pathways and controlling apoptosis.

NPM Function
Nucleophosmin (NPM1) is a cellular protein that has been linked to a variety of processes such as mRNA transport, chromatin remodeling, apoptosis, and genome stability. NPM1 function is important for normal cellular functioning, as evidenced by the fact that NPM1 is frequently overexpressed, altered, rearranged, and sporadically eliminated in cancer. NPM1 may act as both a proto-oncogene and a tumor suppressor, indicating that it has a multifunctional role inside the cell. It would be useful to understand more about NPM1’s less well-known involvement in DNA repair pathways, as well as its role in the control of apoptosis and mutation in malignancies.

Nucleophosmin Family
NPM1 is a member of the Nucleophosmin/nucleoplasmin (NPM) family of histone chaperones, which includes many main functional members (NPM1, NPM2, NPM3, and the invertebrate NPM-like) and is present in all Metazoans. While the operational characteristics of this family are well understood, little is known about the evolution of these genes and proteins.