Nescient Helix Loop Helix

Nescient Helix Loop Helix

Nescient Helix Loop Helix

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  • View Data Sheet

    Description:

    Nescient Helix Loop Helix 2 Human Recombinant

    nescient helix loop helix 2, bHLHa34, HEN2, NSCL2, Class A basic helix-loop-helix protein 34, NHLH2, KIAA0490.

    Product # :

    PRO-1487

    Price :

    Quantity :

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    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    NHLH2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 158 amino acids (1-135 a.a.) and having a molecular mass of 17.4kDa.NHLH2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    NHLH2 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.2M NaCl, 50% glycerol and 5mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Nescient Helix Loop Helix 2 (NHLH2) belongs to the basic helix-loop-helix (bHLH) transcription factor family. NHLH2 is expressed in developing and adult neuroendocrine tissues for example the pituitary and hypothalamus. NHLH2 can act as a DNA-binding protein and may be involved in the control of cell-type determination, probably in the developing nervous system.

    • Synonyms

      nescient helix loop helix 2, bHLHa34, HEN2, NSCL2, Class A basic helix-loop-helix protein 34, NHLH2, KIAA0490.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMMLSPDQ AADSDHPSSA HSDPESLGGT DTKVLGSVSD LEPVEEAEGD GKGGSRAALY PHPQQLSREE KRRRRRATAK YRSAHATRER IRVEAFNLAF AELRKLLPTL PPDKKLSKIE ILRLAICYIS YLNHVLDV.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Nhlh2 Human
  • View Data Sheet

    Description:

    Nescient Helix Loop Helix 1 Human Recombinant

    Nescient Helix Loop Helix 1, Class A Basic Helix-Loop-Helix Protein 35, Helix-Loop-Helix Protein 1, BHLHA35, NSCL1, HEN1.

    Product # :

    PRO-1547

    Price :

    Quantity :

    Shipping Method :

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    Shipped with Ice Packs

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    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    NHLH1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (1-133) and having a molecular mass of 17.0kDa.NHLH1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The NHLH1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 2mM DTT and 40% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      HLH (helix-loop-helix) proteins are a putative transcription factors family. Several HLH proteins take part in growth and development of an extensive range of tissues and species. NHLH1 functions as a DNA-binding protein and has a role in the regulation of cell-type determination in the developing nervous system.

    • Synonyms

      Nescient Helix Loop Helix 1, Class A Basic Helix-Loop-Helix Protein 35, Helix-Loop-Helix Protein 1, BHLHA35, NSCL1, HEN1.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMMLNSDT MELDLPPTHS ETESGFSDCG GGAGPDGAGP GGPGGGQARG PEPGEPGRKD LQHLSREERR RRRRATAKYR TAHATRERIR VEAFNLAFAE LRKLLPTLPP DKKLSKIEIL RLAICYISYL NHVLDV

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Nhlh1 Human

About NHLH / Nescient Helix Loop Helix:

Nescient Helix Loop Helix Protein, aka NHLH, is a gene responsible for protein coding. It is a family of putative transcription factors, some of which have been identified as a crucial component of growing and developing tissues and species.

NHLH Mechanism
NHLH is involved in cell differentiation and contributes to developing the nervous system, allowing it to grow from the early formation stages until it reaches the mature structure. This is clear evidence that NHLH is a crucial element in coordinating everyday function and why it plays a significant part in helping tissues and species develop.
Despite this, as many as four members of the NHLH family have been linked to tumorigenesis through involvement in chromosomal translocation identified within lymphoid tumors.

Nescient Helix Loop Helix Interactions
The Nescient Helix Loop Helix protein interacts with CSRP3, LMO1, LMO2, and LMO4, among other genes. This occurs due to NHL's DNA binding properties, which are absent in some of the genes with which it interacts.

NHLH Function
NHLH may perform as a binding protein for DNA and play a part in cell-type determination, especially with the nervous system.
Besides this, it performs other functions that include RNA polymerization, enables protein binding and protein dimerization activity, and enables sequence-specific double-stranded DNA binding.

Nescient Helix Loop Helix Structure
The NHLH gene is found in humans, but it is also conserved in other mammals. These include chimpanzees, Rhesus monkeys, dogs, and cows. The gene is not restricted to mammals, however, and it is also present in chickens and frogs. In all, there are over 250 organisms that contain orthologs housing the human gene NHLH.