Myelin Basic Protein

Myelin Basic Protein

Myelin Basic Protein

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  • Name :

    MBP Human

    Description:

    Myelin Basic Protein Human Recombinant

    Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein.

    Product # :

    PRO-1713

    Price :

    Quantity :

    Shipping Method :

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    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    MBP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-197) and having a molecular mass of 23.9kDa.MBP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The MBP solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl and 10% glycerol.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      MBP is a major component of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system, although, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs emerge from the long MBP gene which holds three additional exons located upstream of the classic MBP exons. The Golli mRNAs contain three exons unique to Golli-MBP, spliced in-frame to one or more MBP exons. The second family of transcripts contains only MBP exons and produces the well characterized myelin basic proteins. MBP transcription unit is an essential part of the Golli transcription unit and the arrangement is important for the function and/or regulation of these genes.

    • Synonyms

      Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMGNHAGK RELNAEKAST NSETNRGESE KKRNLGELSR TTSEDNEVFG EADANQNNGT SSQDTAVTDS KRTADPKNAW QDAHPADPGS RPHLIRLFSR DAPGREDNTF KDRPSESDEL QTIQEDSAAT SESLDVMASQ KRPSQRHGSK YLATASTMDH ARHGFLPRHR DTGILDSIGR FFGGDRGAPK RGSGKVSSEE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Mbp Protein

About MBP / Myelin Basic Protein:

A protein called myelin essential protein (MBP) is an important building block of the myelin sheath, which provides insulation for nerve cells. It is also in peripheral nerves and other tissues.

MBP Structure
Myelin Basic Protein is a protein that has a vital role in the formation of myelin. Myelin is a substance wrapping around and insulating nerve cells, helping them conduct electrical impulses faster.

Myelin Basic Protein Gene Expression
The MBP gene is on chromosome 17 in humans and a variety of other organisms. Its protein product is myelin basic protein (MBP).

MBP Pathology
Abnormal levels of Myelin Basic Protein can be associated with neurological diseases such as Multiple Sclerosis, Guillain-Barre Syndrome, and some types of spinal cord injury.

Myelin Basic Protein Interactions
Myelin Basic Protein interacts with other molecules called proteoglycans.
Myelin is a fragile sheath that wraps around and insulates nerve cells in the central nervous system (CNS). These proteins are essential for this process because they form the bulk of this thin protective coating.
Myelin Basic Protein levels are markers for neurological diseases like Multiple Sclerosis, Guillain-Barre Syndrome, and some types of spinal cord injury.
These disorders are all characterized by damage to the CNS. Abnormal levels of Myelin Basic Protein relate to neurological diseases such as Multiple Sclerosis, Guillain-Barre Syndrome, and some types of spinal cord injury.

MBP’s Role in Disease
Myelin Basic Protein is vital for the maintenance and repair of nerve cells. When MBP levels are low, it can lead to a disease called Multiple Sclerosis (MS). MS is an autoimmune disease that attacks myelin in the central nervous system. Guillain-Barre Syndrome occurs when your immune system damages parts of your peripheral nervous system.