Mesoderm Development Candidate

Mesoderm Development Candidate

Mesoderm Development Candidate

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Description

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  • View Data Sheet

    Description:

    Mesoderm Development Candidate 2 Mouse Recombinant

    LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Mesdc2, Mesd.

    Product # :

    PRO-2260

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    • description
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    Description

    MESDC2 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 218 amino acids (30-224 a.a) and having a molecular mass of 24.4kDa. MESDC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    MESDC2 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Mesoderm development candidate 2 (MESDC2) is required for formation of the primitive streak and mesoderm during embryogenesis. MESDC2 binds to the Wnt co-receptors LRP5 and LRP6 in the endoplasmic reticulum and is required for their proper folding and cell surface expression.

    • Synonyms

      LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Mesdc2, Mesd.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRREDL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Mesdc2 Mouse
  • View Data Sheet

    Description:

    Mesoderm Development Candidate 2 Human Recombinant

    LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61, MESDC2, KIAA0081, MESD, BOCA.

    Product # :

    PRO-122

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    • description
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    • More Info

    Description

    MESDC2 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 222 amino acids (34-234 a.a.) and having a molecular mass of 24.9kDa (Molecular weight on SDS-PAGE will appear higher). The MESDC2 is purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The MESDC2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Mesoderm development candidate 2 (MESDC2) is required for formation of the primitive streak and mesoderm during embryogenesis. MESDC2 binds to the Wnt co-receptors LRP5 and LRP6 in the endoplasmic reticulum and is required for their proper folding and cell surface expression.

    • Synonyms

      LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61, MESDC2, KIAA0081, MESD, BOCA.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MAEGSPGTPD ESTPPPRKKK KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPVD FSKIDPSKPE SILKMTKKGK TLMMFVTVSG SPTEKETEEI TSLWQGSLFN ANYDVQRFIV GSDRAIFMLR DGSYAWEIKD FLVGQDRCAD VTLEGQVYPG KGGGSKEKNK TKQDKGKKKK EGDLKSRSSK EENRAGNKRE DL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    MESDC2 Human - Prospecbio
  • View Data Sheet

    Description:

    Mesoderm Development Candidate 1 Human Recombinant

    Mesoderm Development Candidate 1, MESDC1.

    Product # :

    PRO-1950

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    Description

    MESDC1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 385 amino acids (1-362) and having a molecular mass of 40.1 kDa.MESDC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The MESDC1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Mesoderm development candidate 1 (MESDC1) is a member of the MESD family. MESDC1 is a 362 amino acid protein encoded by a gene which maps to human chromosome 15q25.1. MESDC1 serves as a chaperone for low-density lipoprotein receptor (LDLR) proteins in the ER, and specifically associates with Wnt signaling pathway coreceptors LRP5 and LPR6. MESDC1 is needed for proper LRP5/6 folding and maturation to the cell surface, which has a key role in Wnt signaling.

    • Synonyms

      Mesoderm Development Candidate 1, MESDC1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMASGSAG KPTGEAASPA PASAIGGASS QPRKRLVSVC DHCKGKMQLV ADLLLLSSEA RPVLFEGPAS SGAGAESFEQ CRDTIIARTK GLSILTHDVQ SQLNMGRFGE AGDSLVELGD LVVSLTECSA HAAYLAAVAT PGAQPAQPGL VDRYRVTRCR HEVEQGCAVL RATPLADMTP QLLLEVSQGL SRNLKFLTDA CALASDKSRD RFSREQFKLG VKCMSTSASA LLACVREVKV APSELARSRC ALFSGPLVQA VSALVGFATE PQFLGRAAAV SAEGKAVQTA ILGGAMSVVS ACVLLTQCLR DLAQHPDGGA KMSDHRERLR NSACAVSEGC TLLSQALRER SSPRTLPPVN SNSVN.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    MESDC1 Human - Prospecbio

About MESDC / Mesoderm Development Candidate:

The Mesoderm Development Candidate 2, professionally known as the MESD (Mesoderm Development LRP Chaperone), is a protein encoded in the MESDC gene in Homo sapiens. This gene concentrates in the thyroid, placenta, and adrenal more than any other tissue in the human body.
The gene goes by many aliases in the medical field. They include KIAA0081, BOCA, OI20, MESD, and Renal Carcinoma Antigen NY-REN-61. It also has related pathways are the Wnt, Hedgehog, and Notch. Moreover, this gene is associated with various diseases in the human body, including Epilepsy, Nocturnal Frontal Lobe, and Type Xx.

MESDC Structure
The MESD gene occurs in many species, including Primates and Chordata. The gene has 234 amino acids, a molecular mass of 2607 Da, and a quaternary structure.

Mesoderm Development Candidate Functions
Mesoderm Development Protein Candidate has various functions on protein coding.
Firstly, MESD assists the beta-propeller/EGF modules in folding within the family of low-density lipoprotein receptors (LPLTs).
Secondly, it acts as a modulator of the Wnt pathway by guiding the receptors of this canonical pathway, the LRP5, and LRP6, to the plasma membrane.
Thirdly, this gene is vital when specifying embryonic polarity and mesoderm induction.
Last but not least, MESD holds a fundamental role in neuromuscular junction (MNJ) formation through promoting cell-surface expression of the LRP4. Sometimes, it May regulate the phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.

MESDC Interaction
MESDC2 is a monomer that interacts with LRP5 to form aggregates and chaperones LRP6 to the plasma membrane. Moreover, it interacts with LPR6 to prevent it from forming aggregates and chaperones for its plasma membrane.
Finally, MESDC2 interacts with LRP4 to promote glycosylation of LRP4 cells-surface expansion.