Lysosomal-Associated Membrane Protein

Lysosomal-Associated Membrane Protein

Lysosomal-Associated Membrane Protein

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  • View Data Sheet

    Description:

    Lysosomal-Associated Membrane Protein 3 Human Recombinant

    Lysosomal-Associated Membrane Protein 3, DC-Lysosome-Associated Membrane Glycoprotein, DC LAMP, LAMP-3, DCLAMP, TSC403, Protein TSC403, CD208 Antigen, DC-LAMP, CD208, LAMP, Lysosome-associated membrane glycoprotein 3.

    Product # :

    PRO-2263

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    Description

    LAMP3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 362 amino acids (28-381a.a.) and having a molecular mass of 38.8kDa. (Molecular size on SDS-PAGE will appear at approximately 57-70kDa). LAMP3 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

    Source

    Sf9, Baculovirus cells.

    Formulation

    LAMP3 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

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    • Introduction

      Lysosomal-Associated Membrane Protein 3, also known as LAMP3 is part of the lysosome-associated membrane protein family. LAMP3 and CD68 share an extremely similar predicted structure. LAMP3 performs in dendritic cell function and in adaptive immunity as well. Furthermore, LAMP3 overexpression is actively involved in tumor invasion via increased migration into lymph-vascular spaces.

    • Synonyms

      Lysosomal-Associated Membrane Protein 3, DC-Lysosome-Associated Membrane Glycoprotein, DC LAMP, LAMP-3, DCLAMP, TSC403, Protein TSC403, CD208 Antigen, DC-LAMP, CD208, LAMP, Lysosome-associated membrane glycoprotein 3.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      KAFPETRDYS QPTAAATVQD IKKPVQQPAK QAPHQTLAAR FMDGHITFQT AATVKIPTTT PATTKNTATT SPITYTLVTT QATPNNSHTA PPVTEVTVGP SLAPYSLPPT ITPPAHTTGT SSSTVSHTTG NTTQPSNQTT LPATLSIALH KSTTGQKPVQ PTHAPGTTAA AHNTTRTAAP ASTVPGPTLA PQPSSVKTGI YQVLNGSRLC IKAEMGIQLI VQDKESVFSP RRYFNIDPNA TQASGNCGTR KSNLLLNFQG GFVNLTFTKD EESYYISEVG AYLTVSDPET IYQGIKHAVV MFQTAVGHSF KCVSEQSLQL SAHLQVKTTD VQLQAFDFED DHFGNVDECS SDYTLEHHHH HH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Lamp3 Human
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    Description:

    Lysosomal-Associated Membrane Protein 2 Human Recombinant

    Lysosomal-associated membrane protein 2, CD107b, LAMP-2, CD107 antigen-like family member B, LGP110, LAMP2.

    Product # :

    PRO-130

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    Description

    LAMP2 is a full-length cDNA coding for the human lysosomal-associated membrane protein 2 having a molecular mass of 42,488 Dalton (pH 5.88). LAMP2 protein is fused to a deca-histidine purification tag.

    Source

    Sf9 insect cells.

    Formulation

    LAMP2 (0.94mg/ml) is supplied in 16mM HEPES buffer pH-8.0, 130mM NaCl and 20% Glycerol.

    More Info

    • Introduction

      The protein encoded by LAMP2 belongs to a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands LAMP2 takes part in tumor cell metastasis and in addition has a role in the protection, maintenance, and adhesion of the lysosome. The effect of alternative splicing of this gene is multiple transcript variants encoding distinct proteins.

    • Synonyms

      Lysosomal-associated membrane protein 2, CD107b, LAMP-2, CD107 antigen-like family member B, LGP110, LAMP2.

    • Stability

      Store LAMP2 at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Lamp2 Human
  • View Data Sheet

    Description:

    Lysosomal-Associated Membrane Protein 2 Mouse Recombinant

    Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, Lysosomal membrane glycoprotein type B, LGP-B, CD107b.

    Product # :

    PRO-2330

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    Description

    LAMP2 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 362 amino acids (26-379 a.a.) and having a molecular mass of 40.2kDa (Molecular size on SDS-PAGE will appear at approximately 50-70kDa).LAMP2 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

    Source

    Sf9, Baculovirus cells.

    Formulation

    LAMP2 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      The protein encoded by LAMP2 belongs to a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands LAMP2 takes part in tumor cell metastasis and in addition has a role in the protection, maintenance, and adhesion of the lysosome. The effect of alternative splicing of this gene is multiple transcript variants encoding distinct proteins.

    • Synonyms

      Lysosome-associated membrane glycoprotein 2, LAMP-2, Lysosome-associated membrane protein 2, CD107 antigen-like family member B, Lysosomal membrane glycoprotein type B, LGP-B, CD107b.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

    • Amino Acid Sequence

      LIVNLTDSKG TCLYAEWEMN FTITYETTNQ TNKTITIAVP DKATHDGSSC GDDRNSAKIM IQFGFAVSWA VNFTKEASHY SIHDIVLSYN TSDSTVFPGA VAKGVHTVKN PENFKVPLDV IFKCNSVLTY NLTPVVQKYW GIHLQAFVQN GTVSKNEQVC EEDQTPTTVA PIIHTTAPST TTTLTPTSTP TPTPTPTPTV GNYSIRNGNT TCLLATMGLQ LNITEEKVPF IFNINPATTN FTGSCQPQSA QLRLNNSQIK YLDFIFAVKN EKRFYLKEVN VYMYLANGSA FNISNKNLSF WDAPLGSSYM CNKEQVLSVS RAFQINTFNL KVQPFNVTKG QYSTAQDCSA DEDNLEHHHH HH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Lamp2 Mouse
  • View Data Sheet

    Description:

    Lysosomal-Associated Membrane Protein Human 1 Recombinant

    Lysosome-associated membrane glycoprotein 1, LAMP1, CD107a, LAMPA, LGP120, LAMP-1, CD107 antigen-like family member A.

    Product # :

    PRO-2478

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    Description

    LAMP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 363 amino acids (29-382a.a.) and having a molecular mass of 39.4kDa. (Molecular size on SDS-PAGE will appear at approximately 57-70kDa).LAMP1 is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

    Source

    Sf9, Baculovirus cells.

    Formulation

    LAMP1 protein solution (1mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Lysosomal-Associated Membrane Protein 1 (LAMP1) is a part of the LAMP family. LAMP1 is a membrane protein which is expressed in the endosome-lysosome membranes of cells and is implicated in tumor cell metastasis. A glycoform of LAMP1 is expressed on the surface of activated macrophages and promotes T cell costimulation and a Th1 biased immune response. LAMP1 is also found on the plasma membrane during the activation of NK cells, CD8 & T cells, monocytes, basophils, and platelets.

    • Synonyms

      Lysosome-associated membrane glycoprotein 1, LAMP1, CD107a, LAMPA, LGP120, LAMP-1, CD107 antigen-like family member A.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      ADPAMFMVKN GNGTACIMAN FSAAFSVNYD TKSGPKNMTF DLPSDATVVL NRSSCGKENT SDPSLVIAFG RGHTLTLNFT RNATRYSVQL MSFVYNLSDT HLFPNASSKE IKTVESITDI RADIDKKYRC VSGTQVHMNN VTVTLHDATI QAYLSNSSFS RGETRCEQDR PSPTTAPPAP
      PSPSPSPVPK SPSVDKYNVS GTNGTCLLAS MGLQLNLTYE RKDNTTVTRL LNINPNKTSA SGSCGAHLVT LELHSEGTTV LLFQFGMNAS SSRFFLQGIQ LNTILPDARD PAFKAANGSL RALQATVGNS YKCNAEEHVR VTKAFSVNIF KVWVQAFKVE GGQFGSVEEC LLDENSMHHH
      HHH

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Lamp1 Human

About LAMP / Lysosomal-Associated Membrane Protein:

Lysosomal-Associated Membrane Proteins (LAMP) are types of integral membrane protein present in the lysosomal system. This lysosomal system is an intracellular mechanism which controls the replacement of endogenous and exogenous macromolecules. Lysosomes essentially perform waste disposal in cells. LAMPs account for 50% of the proteins found in the lysosomal membrane. The prominent LAMPs in mammals, LAMP1 and LAMP2 closely interact and a deficiency in either has been linked to certain medical conditions. For example, a deficiency of LAMP-2 is the primary defect in Danon disease.

LAMP Structure
LAMP proteins are made up of a short cytosolic domain of 10-20 amino acids containing single tyrosine or di-leucine motifs. Structurally they consist of two internally homogenous lysosome-luminal domains separated by a proline-rich hinge region. They have a C-terminal extremity where a transmembrane region is located as well as a cytoplasmic tail. Each of the domains contains two disulfide bonds.

Lysosomal-Associated Membrane Protein Function
LAMPs interact with adaptor complexes (APS) affecting the trans-Golgi network and targeting lysosomes. LAMP1 and LAMP2 also interact closely with one another. As well as being structurally alike they are thought to have similar functions. They provide selectins with carbohydrate ligands. They’ve also been shown to stimulate lymphocyte cells in the immune system to release antimicrobial cytotoxicity to destroy invading microorganisms. Both have been connected to tumor cell differentiation and metastasis. Whereas the exact biological functions of LAMP proteins are still unclear, they are mainly associated with the protection, maintenance and adhesion of lysosomes which play a vital role in many cell processes.