Leptin

Leptin

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Description

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  • View Data Sheet

    Description:

    Leptin Human Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-228

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

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    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:
    (a) Analysis by Gel filtration.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Human
  • View Data Sheet

    Description:

    Leptin Human Recombinant, PEG

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-1108

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

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    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Protein content
    Leptin Mutant
  • View Data Sheet

    Description:

    Leptin Mutant D23L Human Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-1243

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

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    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    Mutant Leptin
  • View Data Sheet

    Description:

    Leptin Antagonist Triple Mutant Pegylated Rat Recombinant

    Product # :

    CYT-567

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

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    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Protein content
    Leptin Ta Rat Peg
  • View Data Sheet

    Description:

    Leptin Antagonist Triple Mutant Rat Recombinant

    Product # :

    CYT-355

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Ta Rat
  • View Data Sheet

    Description:

    Leptin Triple Antagonist (D23L) Pegylated Mouse Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-1242

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    Leptin Mouse Peg Ta
  • View Data Sheet

    Description:

    Leptin Antagonist Triple Mutant Pegylated Mouse Recombinant

    Product # :

    CYT-566

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Protein content
    Leptin Ta Mouse Peg
  • View Data Sheet

    Description:

    Leptin Antagonist Triple Mutant Mouse Recombinant

    Product # :

    CYT-354

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Ta Mouse
  • View Data Sheet

    Description:

    Leptin Antagonist Triple Mutant Human Recombinant, Pegylated

    Product # :

    CYT-702

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Protein content
    Leptin Ta Human Pegylated
  • View Data Sheet

    Description:

    Leptin Antagonist Triple Mutant Human Recombinant

    Product # :

    CYT-352

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Ta Human
  • View Data Sheet

    Description:

    Leptin Super Antagonist Rat Recombinant

    Product # :

    CYT-1240

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    Leptin Antagonist Super Rat
  • View Data Sheet

    Description:

    Leptin Super Antagonist Human Recombinant

    Product # :

    CYT-1238

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    Leptin Antagonist Super Human
  • View Data Sheet

    Description:

    Leptin Salamander Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor, Leptin.

    Product # :

    CYT-704

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Analysis by Gel-Filtration.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Salamander
  • View Data Sheet

    Description:

    Leptin Receptor Chicken Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor, Leptin Receptor.

    Product # :

    CYT-509

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Amino Acid Sequence
    • Protein content
    Leptin Receptor Chicken
  • View Data Sheet

    Description:

    Pegylated Rat Leptin Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-592

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Analysis by Gel-Filtration.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    Leptin Rat Pegylated
  • View Data Sheet

    Description:

    Leptin Rat Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-227

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Rat
  • View Data Sheet

    Description:

    Leptin Rabbit Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-507

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Rabbit
  • View Data Sheet

    Description:

    Leptin Quadruple Antagonist, Pegylated Rat Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-1241

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    Leptin Rat Peg Qa
  • View Data Sheet

    Description:

    Leptin Quadruple Antagonist Pegylated Ovine Recombinant

    Product # :

    CYT-1246

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Protein content
    Leptin Antagonist Peg Ovine
  • View Data Sheet

    Description:

    Leptin Quadruple Antagonist Pegylated Mouse Recombinant

    Product # :

    CYT-1244

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Protein content
    Leptin Mouse Ta Peg
  • View Data Sheet

    Description:

    Leptin Quadruple Antagonist Mouse Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-1257

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Mouse Antagonist
  • View Data Sheet

    Description:

    Leptin Quadruple Antagonist Pegylated Human Recombinant

    Product # :

    CYT-1251

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Protein content
    Leptin Human Qa Peg
  • View Data Sheet

    Description:

    Leptin Antagonist Quadruple Mutant Human Recombinant

    Product # :

    CYT-353

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Qa Human
  • View Data Sheet

    Description:

    Leptin Pufferfish Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-530

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Pufferfish
  • View Data Sheet

    Description:

    Leptin Porcine Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-503

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Porcine
  • View Data Sheet

    Description:

    Leptin Ovine Recombinant, MTS tag

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-531

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Ovine Mts
  • View Data Sheet

    Description:

    Leptin Ovine Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-239

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Ovine
  • View Data Sheet

    Description:

    Leptin N82K Human Recombinant, Pegylated

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-1107

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    Leptin Mutant Protein
  • View Data Sheet

    Description:

    Pegylated Mouse Leptin Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-591

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 99.0% as determined by:
    (a) Analysis by Gel-Filtration.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    Leptin Mouse Pegylated
  • View Data Sheet

    Description:

    Leptin D23L Mutant Mouse Recombinant

    Product # :

    CYT-1249

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Mouse Mutant
  • View Data Sheet

    Description:

    Leptin Mouse Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-351

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:
    (a) Analysis by gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Mouse
  • View Data Sheet

    Description:

    Leptin Human Recombinant, His Tag

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-287

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    Leptin Human His
  • View Data Sheet

    Description:

    Human Leptin

    OB Protein, Obesity Protein, OBS, Obesity factor, Leptin.

    Product # :

    CYT-683

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by RP-HPLC.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    Leptin Synthetic
  • View Data Sheet

    Description:

    Leptin Horse Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-504

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Horse
  • View Data Sheet

    Description:

    Leptin Dog Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-506

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Dog
  • View Data Sheet

    Description:

    Leptin Chicken Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-505

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 95.0% as determined by:
    (a) Analysis by SEC-HPLC.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Chicken
  • View Data Sheet

    Description:

    Leptin Bovine Recombinant

    OB Protein, Obesity Protein, OBS, Obesity factor.

    Product # :

    CYT-502

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Introduction
    • Synonyms
    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Bovine
  • View Data Sheet

    Description:

    Leptin Antagonist Triple Mutant Ovine Recombinant

    Product # :

    CYT-356

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:
    (a) Gel filtration analysis.
    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Ta Ovine
  • View Data Sheet

    Description:

    Super Leptin Antagonist Ovine Recombinant

    Product # :

    CYT-1245

    Price :

    Quantity :

    Shipping Method :

    Room Temp Icon

    Shipped at Room temp

    Add To Cart

    More Info

    • purity
    • More Info

    Purity

    Greater than 98.0% as determined by:

    (a) Gel filtration analysis.

    (b) Analysis by SDS-PAGE.

    More Info

    • Physical Appearance
    • Stability
    • Solubility
    • Amino Acid Sequence
    • Protein content
    Leptin Super Antagonist Ovine

About Leptin:

Leptin is a hormone that is primarily made from adipose cells that assist in regulating energy balance by inhibiting hunger. Leptin is the opposite of ghrelin which is known as the hunger hormone. Both of these hormones act on receptors found in the arcuate nucleus of the hypothalamus to regulate appetite and also help to achieve energy homeostasis. Regulation of fat stores is the primary function of leptin, but it also plays a part in other physiological processes. These functions are evidenced by the synthesis at multiple sites other than the fat cells, but many of these have yet to be defined and require more research.

Identification
Several discoveries were found between 1950 and 1995 that lead to the identification of leptin. In 1949, a non-obese colon of mice being studied at the Jackson Laboratory produced a strain of obese offspring, suggesting that a mutation had occured in the hormones that regulated hunger and energy expenditure. In 1960, a second mutation was observed by Douglas Coleman, also at the Jackson Laboratory and was named diabetes (db) as both ob/bo and db/db were obese. In 1990, Rudolph Leibel and Jeffrey M. Freidman reported that they had mapped the db gene. In 1994, Freidman’s laboratory reported that they had identified the ob gene.

Location of Action
Leptin acts directly on leptin receptors in the cell membrane of various different cells in the human body. In particular, it acts on vertebrates in general. The leptin receptor is located in a variety of different cell types. It is a single-transmembrane-domain type I cytokine receptor. This is a special class of cytokine receptors. Furthermore, leptin interacts with other hormones and energy regulators to indirectly mediate the effects of glucagon, insulin, insulin-like growth factor, growth hormone, glucocorticoids, cytokines and metabolites.

Mode of Action
The central location of action of fat cell-specific leptin is the hypothalamus, which is a party of the brain. This is the part of which the central nervous system is located. Non-hypothalamic targets of leptin are often referred to as peripheral targets. There is a difference between central and peripheral leptin interactions under different physiological states and variations between different species.

Function
The main function of leptin is to regulate the adipose tissue mass through central hypothalamus mediated effects on hunger, physical exercise, energy balance and food energy use. In the body, leptin’s secondary functions include the modulation of energy expenditure, modulation between fetal and maternal metabolism, and plays a permissive role in puberty, activator of beta islet cells, activator of immune cells and growth factor.

Structure
Human leptin is a 16-kDa protein of 167 amino acids. The Ob(Lep) gene (Obese, Leptin) is found on the chromosome 7 in humans.