KCTD

KCTD

KCTD

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  • View Data Sheet

    Description:

    Potassium Channel Tetramerisation Domain Containing 5 Human Recombinant

    BTB/POZ domain-containing protein KCTD5, KCTD5.

    Product # :

    PRO-1276

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    Description

    KCTD5 Human Recombinant produced in E. coli is a single polypeptide chain containing 257 amino acids (1-234) and having a molecular mass of 28.5 kDa. KCTD5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The KCTD5 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

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    • Introduction

      BTB/POZ domain-containing protein KCTD5 (KCTD5), is a 234 amino acid protein which localizes mainly in the cytoplasm however translocates to the nucleus on interaction with REP proteins. The expression of KCTD5 is up regulated post-transcriptionally in peripheral blood lymphocytes stimulated via the T-cell receptor. KCTD5 interacts particularly with cullin3, attaches ubiquitinated proteins, and created oligomers through its BTB domain.

    • Synonyms

      BTB/POZ domain-containing protein KCTD5, KCTD5.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMAENHCE LLSPARGGIG AGLGGGLCRR CSAGLGALAQ RPGSVSKWVR LNVGGTYFLT TRQTLCRDPK SFLYRLCQAD PDLDSDKDET GAYLIDRDPT YFGPVLNYLR HGKLVINKDL AEEGVLEEAE FYNITSLIKL VKDKIRERDS KTSQVPVKHV YRVLQCQEEE LTQMVSTMSD GWKFEQLVSI GSSYNYGNED QAEFLCVVSK ELHNTPYGTA SEPSEKAKIL QERGSRM

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Kctd5 Human
  • View Data Sheet

    Description:

    Potassium Channel Tetramerisation Domain Containing 4 Human Recombinant

    Potassium Channel Tetramerization Domain Containing 4, Potassium Channel Tetramerisation Domain Containing 4, bA321C24.3, BTB/POZ Domain-Containing Protein KCTD4.

    Product # :

    PRO-1763

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    Description

    KCTD4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 282 amino acids (1-259 a.a) and having a molecular mass of 32.4kDa.KCTD4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    KCTD4 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 40% glycerol and 1mM DTT.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      KCTD4 also known as Potassium Channel Tetramerisation Domain Containing 4 has an N-terminal homodimerization domain which contains multiple copies of kelch repeats and C2H2-type zinc fingers. Proteins which include BTB domains are consider being involved in transcriptional regulation through control of chromatin structure and function. In addition, KCTD4 is a 259 amino acid protein which contains one BTB domain, a possible role as a transcriptional regulator may be suggested.

    • Synonyms

      Potassium Channel Tetramerization Domain Containing 4, Potassium Channel Tetramerisation Domain Containing 4, bA321C24.3, BTB/POZ Domain-Containing Protein KCTD4.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMERKINR REKEKEYEGK HNSLEDTDQG KNCKSTLMTL NVGGYLYITQ KQTLTKYPDT FLEGIVNGKI LCPFDADGHY FIDRDGLLFR HVLNFLRNGE LLLPEGFREN QLLAQEAEFF QLKGLAEEVK SRWEKEQLTP RETTFLEITD NHDRSQGLRI FCNAPDFISK IKSRIVLVSK SRLDGFPEEF SISSNIIQFK YFIKSENGTR LVLKEDNTFV CTLETLKFEA IMMALKCGFR LLTSLDCSKG SIVHSDALHF IK

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Kctd4 Human
  • View Data Sheet

    Description:

    Potassium Channel Tetramerisation Domain Containing 15 Human Recombinant

    BTB/POZ domain-containing protein KCTD15, Potassium channel tetramerisation domain containing 15, KCTD15, MGC2628, MGC25497.

    Product # :

    PRO-1002

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    Description

    KCTD15 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 254 amino acids (1-234 a.a) and having a molecular mass of 28.6kDa.KCTD15 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    KCTD15 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      KCTD15 protein is encoded in humans by the KCTD15 gene. KCTD15 is expressed at a high level in the brain and the hypothalamus. The potassium channel KCTD15 was identified as a genetic loci linked to higher than normal BMI in humans along with genes such as GNPDA2, MTCH2, FTO, and TMEM18. SNPs (Single nucleotide polymorphisms) in non-diabetic and diabetic patients showed that FTO was most strongly associated with obesity while MTCH2 and GNPDA2 were still notably associated with higher than normal BMI levels.

    • Synonyms

      BTB/POZ domain-containing protein KCTD15, Potassium channel tetramerisation domain containing 15, KCTD15, MGC2628, MGC25497.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ LTKSNAPVHI DVGSHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH YFIDRDGEIF RYVLSFLRTS KLLLPDDFKD FSLLYEEARY YQLQPMVREL ERWQQEQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QDVL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Kctd15 Human
  • View Data Sheet

    Description:

    Potassium Channel Tetramerisation Domain Containing 11 Human Recombinant

    C17orf36, KCASH1, MGC129844, REN, REN/KCTD11, KCTD11, BTB/POZ domain-containing protein KCTD11.

    Product # :

    PRO-1376

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    Description

    KCTD11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-232a.a) and having a molecular mass of 28kDa. KCTD11 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    KCTD11 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      Potassium Channel Tetramerisation Domain Containing 11 (KCTD11) is a 232 amino acid regulator of neuronal differentiation which induces growth arrest, apoptosis and the expression of p27 (cyclin-dependent kinase inhibitor). KCTD11 is expressed most highly in cerebellum. KCTD11 functions as an antagonist of the Hedgehog pathway and activator of the caspase cascade and among its related super-pathways are Melatonin Signaling and Activation of cAMP-Dependent PKA.

    • Synonyms

      C17orf36, KCASH1, MGC129844, REN, REN/KCTD11, KCTD11, BTB/POZ domain-containing protein KCTD11.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MLGAMFRAGT PMPPNLNSQG GGHYFIDRDG KAFRHILNFL RLGRLDLPRG YGETALLRAE ADFYQIRPLL DALRELEASQ GTPAPTAALL HADVDVSPRL VHFSARRGPH HYELSSVQVD TFRANLFCTD SECLGALRAR FGVASGDRAE GSPHFHLEWA PRPVELPEVE YGRLGLQPLW TGGPGERREV VGTPSFLEEV LRVALEHGFR LDSVFPDPED LLNSRSLRFV RH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Kctd11 Human

About KCTD / Potassium Channel Tetramerization Domain:

The N-terminal, cytoplasmic tetramerization region (T1) of voltage-gated K+ channels is known as the K+ channel tetramerization domain (T1). It identifies molecular factors for alpha-subunit subfamily-specific assembly into functional tetrameric channels. It is distantly connected to the Pfam PF00651 BTB/POZ domain.

KCTD Function
The potassium channel family is the most varied of the ion channel family. They have an essential role in the formation of the action potential and neuronal excitability and plasticity. The potassium channel family comprises multiple functionally diverse isoforms that can be divided into two groups: the nearly non-inactivating 'delayed' group and the fast inactivating 'transient' group.

Potassium Channel Tetramerization Domain Mechanism
The voltage-dependent gating mechanism, channel conductance, and toxin binding properties of these proteins are relatively similar, with only minor amino acid changes generating variation.
Depending on the type of regulation, each type of K+ channel is activated by different signals and conditions: some open in response to plasma membrane depolarization; others in response to hyperpolarization or an increase in intracellular calcium concentration; some can be regulated by binding of a transmitter in conjunction with intracellular kinases, and GTP-binding regulates others. K+ channels are involved in brain signaling and heart rhythm creation in eukaryotic cells, operate as effectors in signal transduction pathways involving G protein-coupled receptors (GPCRs), and may play a role in target cell lysis by cytotoxic T-lymphocytes. They are involved in the maintenance of ionic homeostasis in bacterial cells.