Homer Homolog

Homer Homolog

Homer Homolog

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  • View Data Sheet

    Description:

    Homer Homolog-3 Human Recombinant

    Homer homolog 3 (Drosophila)1 2 , HOMER-31 2 , homer protein homolog 32 , Homer neuronal immediate early gene 32, Homer-33, VESL32.

    Product # :

    PRO-1108

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    Description

    HOMER3 Human Recombinant produced in E. coli is a single polypeptide chain containing 386 amino acids (1-361) and having a molecular mass of 42.5kDa.HOMER3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The HOMER3 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 150mM NaCl, 1mM DTT and 30% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

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    • Introduction

      HOMER3 belongs to the HOMER family of postsynaptic density scaffolding proteins which have an analogous domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain that facilitates protein-protein relations, and two leucine zipper and a carboxy-terminal coiled-coil domain motifs which take part in self-oligomerization.

    • Synonyms

      Homer homolog 3 (Drosophila)1 2 , HOMER-31 2 , homer protein homolog 32 , Homer neuronal immediate early gene 32, Homer-33, VESL32.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMMSTAR EQPIFSTRAH VFQIDPATKR NWIPAGKHAL TVSYFYDATR NVYRIISIGG AKAIINSTVT PNMTFTKTSQ KFGQWADSRA NTVYGLGFAS EQHLTQFAEK FQEVKEAARL AREKSQDGGE LTSPALGLAS HQVPPSPLVS ANGPGEEKLF RSQSADAPGP TERERLKKML SEGSVGEVQW EAEFFALQDS NNKLAGALRE ANAAAAQWRQ QLEAQRAEAE RLRQRVAELE AQAASEVTPT GEKEGLGQGQ SLEQLEALVQ TKDQEIQTLK SQTGGPREAL EAAEREETQQ KVQDLETRNA ELEHQLRAME RSLEEARAER ERARAEVGRA AQLLDVSLFE LSELREGLAR LAEAAP

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Homer3 Human
  • View Data Sheet

    Description:

    Homer Homolog-2 Human Recombinant

    Homer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A/2B), Vesl-2, ACPD, Cupidin, CPD.

    Product # :

    PRO-1072

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    Description

    HOMER2 Human Recombinant produced in E. coli is a single polypeptide chain containing 368 amino acids (1-343) and having a molecular mass of 42.1kDa.HOMER2 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The HOMER2 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      HOMER2 belongs to the homer family of dendritic proteins which are immediate early gene products who bind to group 1 metabotropic glutamate receptors (mGluRs), proteins associated to triggering intracellular calcium release. Additionally, HOMER2 conect mGluRs to the inositol triphosphate receptors (IP3R).

    • Synonyms

      Homer homolog 2 (Drosophila), homer neuronal immediate early gene 2, homer homolog 3, HOMER-2 (2A/2B), Vesl-2, ACPD, Cupidin, CPD.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMMGEQP IFTTRAHVFQ IDPNTKKNWM PASKQAVTVS YFYDVTRNSY RIISVDGAKV IINSTITPNM TFTKTSQKFG QWADSRANTV FGLGFSSEQQ LTKFAEKFQE VKEAAKIAKD KTQEKIETSS NHSQASSVNG TDDEKASHAG PANTHLKSEN DKLKIALTQS AANVKKWEIE LQTLRESNAR LTTALQESAA SVEQWKRQFS ICRDENDRLR NKIDELEEQC SEINREKEKN TQLKRRIEEL EAELREKETE LKDLRKQSEI IPQLMSECEY VSEKLEAAER DNQNLEDKVR SLKTDIEESK YRQRHLKVEL KSFLEVLDGK IDDLHDFRRG LSKLGTDN

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Homer2 Human
  • View Data Sheet

    Description:

    Homer Homolog-1 Human Recombinant

    HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.

    Product # :

    PRO-695

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    Description

    Recombinant Human HOMER1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 391 amino acids (1-354 a.a) and having a molecular mass of 44.5 kDa. HOMER1 is fused to a 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The HOMER1 protein (1mg/ml) contains 20mM Tris-HCl buffer pH-8, 1mM DTT, 0.1M NaCl and 20% glycerol.

    Purity

    Greater than 90% as determined by Analysis by SDS-PAGE.

    More Info

    • Introduction

      HOMER1 takes part in determining the apoptotic susceptibility to TRAIL.
      HOMER1 is a member of the Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, plus maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The HOMER1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs).

    • Synonyms

      HOMER, SYN47, Ves-1, HOMER1A, HOMER1B, HOMER1C, HOMER1, Homer protein homolog 1.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE QPIFSTRAHV FQIDPNTKKN WVPTSKHAVT VSYFYDSTRN VYRIISLDGS KAIINSTITPNMTFTKTSQK FGQWADSRAN TVYGLGFSSE HHLSKFAEKF QEFKEAARLA KEKSQEKMEL TSTPSQESAG GDLQSPLTPE SINGTDDERT PDVTQNSEPR AEPTQNALPF SHSSAISKHW EAELATLKGN NAKLTAALLE STANVKQWKQ QLAAYQEEAE RLHKRVTELE CVSSQANAVH THKTELNQTI QELEETLKLK EEEIERLKQE IDNARELQEQ RDSLTQKLQE VEIRNKDLEG QLSDLEQRLE KSQNEQEAFR NNLKTLLEIL DGKIFELTEL RDNLAKLLEC S.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Homer1 Human

About HOMER / Homer Homolog:

Homer protein homolog 1 is a neuronal protein. In human beings, the HOMER1 gene decodes homer protein homolog 1 (Homer1).

HOMER Aliases
Homer protein homolog 1 is also known as:
●HOMER1
●HOMER1A
●HOMER1B
●HOMER1C
●Ves-l
●Homer scaffolding protein
●PSD-Zip45

Homer Homolog Structure
Homer1 protein has two terminal domains: the N-terminal EVH1 domain is involved in protein interaction and the C-terminal coiled-coil domain is involved in self-association. There are two primary splice variants: these are short-form, known as Homer1a, and long-form, known as Homer1b and Homer1c. In the Homer1a variant, there is only an EVH1 domain. The long-form variants have both EVH1 and coiled-coil domains. The coiled-coil can be broken down further into two halves, the N-terminal and the C-terminal.
When examined as a whole, the long-form Homer1 protein is said to resemble a dumbbell with two EVH1 domains positioned at the end of a coiled-coil domain.
Mammals have Homer2 and Homer3 proteins, as well as Homer1.

HOMER Function
Homer1 is expressed predominantly in the central nervous system, as well as within periphery tissue, including the kidneys, ovaries, testes, skeletal muscle and heart. Homer1 proteins work like scaffolding that forms clusters. This protein is involved in linking metabotropic glutamate receptors to other effectors to regulate the activity of mGluR.
EVH1 domain interacts with PPXXF, which is found in a host of receptors, including group 1 metabotropic glutamate receptor, IP3 receptors, Shank, transient receptor potential canonical family channels, ryanodine receptors, drebrin and dynamin3. Long-form Homer1 proteins cross-link different proteins.
Neuronal activity triggers the expression of Homer1a while Homer1b and Homer1c are constitutive. Homer1a is known as an immediate early gene and it can perform as a negative actor that blocks interaction between long-forms and their ligand proteins. Short-form Homer1 protein is therefore able to shrink dendritic structure. It is also part of the mechanism of homeostatic plasticity, which reduces activity when input rises too steeply. Coiled-coil interaction with Cdc42 prevents Cdc42 activity to reform dendritic spine structure.