Hematological And Neurological Expressed

Hematological And Neurological Expressed

Hematological And Neurological Expressed

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    Description:

    Hematological and Neurological Expressed 1-Like Human Recombinant

    C16orf34, L11, Hematological and neurological expressed 1-like protein, HN1-like protein.

    Product # :

    PRO-027

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    • description
    • source
    • formulation
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    Description

    HN1L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-190 a.a.) and having a molecular mass of 22.5kDa.HN1L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    HN1L protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

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    • Introduction

      Hematological and neurological expressed 1-like ( HN1L) is a member of the HN1 family.HN1L is anticipated to participate in embryo development. HN1L is expressed in a variety of tissues for example :liver, kidney, prostate, testis and uterus at different levels.

    • Synonyms

      C16orf34, L11, Hematological and neurological expressed 1-like protein, HN1-like protein.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMFQVPDS EGGRAGSRAM KPPGGESSNL FGSPEEATPS SRPNRMASNI FGPTEEPQNI PKRTNPPGGK GSGIFDESTP VQTRQHLNPP GGKTSDIFGS PVTATSRLAH PNKPKDHVFL CEGEEPKSDL KAARSIPAGA EPGEKGSARK AGPAKEQEPM PTVDSHEPRL GPRPRSHNKV LNPPGGKSSI SFY.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Hn1L Human
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    Description:

    Hematological And Neurological Expressed 1 Human Recombinant

    ARM2, HN1A, Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, HN1.

    Product # :

    PRO-1434

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    • description
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    • More Info

    Description

    HN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 174 amino acids (1-154) and having a molecular mass of 18.1kDa. HN1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The HN1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 10% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      Hematological and neurological expressed 1 protein (HN1) is a small protein which is extremely preserved among species. HN1 expression is upregulated in regenerating neural tissues, including the axotomized adult rodent facial motor nerve and dedifferentiating retinal pigment epithelial cells of the Japanese newt. HN1 is also expressed in several tissues during embryonic development as well as in regions of the adult brain which display high plasticity.

    • Synonyms

      ARM2, HN1A, Hematological and neurological expressed 1 protein, Androgen-regulated protein 2, HN1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MTTTTTFKGV DPNSRNSSRV LRPPGGGSNF SLGFDEPTEQ PVRKNKMASN IFGTPEENQA SWAKSAGAKS SGGREDLESS GLQRRNSSEA SSGDFLDLKG EGDIHENVDT DLPGSLGQSE EKPVPAAPVP SPVAPAPVPS RRNPPGGKSS LVLG.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Hn1 Human

About HN1 / Hematological And Neurological Expressed:

Hematological and neurological (HN1) expressed protein is a protein found in humans and other organisms that is encoded by the HN1 gene. The JPT1 gene / cDNA is a protein coding gene found in around 235 different organisms, including chimpanzees, dog, cow, mouse, rat, chicken, monkey, and frog. Looking at the functionality and makeup of this protein is important for helping us figure out the role it plays in the body, and what makes it so essential. HN1 protein expression tissue specificity is expressed in skeletal muscle, prostate, colon, brain, placenta, and more.

HN1 Function
It plays a role in cell growth, and is known to function by modulating negatively AKT-mediated GSK3B signalling. It induces Ser-33 degradation and phosphorylation through the suppression of Ser-9 phosphorylation of GSK3B. It also plays an important role in regulating cell cycles and cell adhesion. The protein works by inhibiting the AR-signalling pathways via the induction of receptor proteasomal degradation.

Hematological And Neurological Expressed Antibodies
HN1 has 2 distinct antibodies, and they are validated in multiple tissues, with various different applications. ELISA is one such application, for which there are also 2 HN1 antibodies, and some of these are found/produced in rabbits and mice.