GIPC PDZ Domain

GIPC PDZ Domain

GIPC PDZ Domain

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    Description:

    GIPC PDZ Domain Member 2 Human Recombinant

    GIPC PDZ domain containing family member 2, SEMCAP-2, PDZ domain-containing protein GIPC2, semaphorin cytoplasmic domain associated protein 2, semaF cytoplasmic domain associated protein 2, SEMCAP2, FLJ20075.

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    PRO-1035

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    Description

    GIPC2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 339 amino acids (1-315) and having a molecular mass of 36.9kDa.GIPC2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The GIPC2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl, 1mM DTT and 30% glycerol.

    Purity

    Greater than 95% as determined by SDS-PAGE.

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    • Introduction

      GIPC2 is a 315 aa protein which is restricted to the cytoplasm and holds one PDZ domain. GIPC2 is expressed in large quantities in colon and kidney and in small quantities in adult liver. GIPC2 has a vital part in human gastric cancer by control of growth factor signaling or cell adhesion.

    • Synonyms

      GIPC PDZ domain containing family member 2, SEMCAP-2, PDZ domain-containing protein GIPC2, semaphorin cytoplasmic domain associated protein 2, semaF cytoplasmic domain associated protein 2, SEMCAP2, FLJ20075.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMPLKLR GKKKAKSKET AGLVEGEPTG AGGGSLSASR APARRLVFHA QLAHGSATGR VEGFSSIQEL YAQIAGAFEI SPSEILYCTL NTPKIDMERL LGGQLGLEDF IFAHVKGIEK EVNVYKSEDS LGLTITDNGV GYAFIKRIKD GGVIDSVKTI CVGDHIESIN GENIVGWRHY DVAKKLKELK KEELFTMKLI EPKKAFEIEP RSKAGKSSGE KIGCGRATLR LRSKGPATVE EMPSETKAKA IEKIDDVLEL YMGIRDIDLA TTMFEAGKDK VNPDEFAVAL DETLGDFAFP DEFVFDVWGV IGDAKRRGL

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Gipc2 Human
  • View Data Sheet

    Description:

    GIPC PDZ Domain Member 1 Human Recombinant

    PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, Tax interaction protein 2, TIP-2, GIPC1, C19orf3, GIPC, RGS19IP1, NIP, GIPC, IIP-1, SEMCAP, Hs.6454, MGC3774, GLUT1CBP, MGC15889. SYNECTIN, SYNECTIIN.

    Product # :

    PRO-855

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    Description

    GIPC1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 353 amino acids (1-333 a.a) and having a molecular mass of 38.2kDa. The GIPC1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    GIPC1 Human solution (0.5mg/ml) containing 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl, 1mM EDTA & 20% glycerol.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      GIPC1 is a PDZ domain protein that cooperates with RGS-GAIP and the viral oncoprotein TAX, which transactivates viral and cellular promoters throughout interactions with different transcription factors. GIPC1 particularly localizes to clusters of vesicles close to the plasma membrane and takes part in G protein-coupled signaling pathway participating in regulating Clathrin-coated vesicular trafficking. GIPC1 cooperates with membrane bound Semaphorin F, which is takes part in neuronal axon growth, and controls the subcellular distribution of M-SemF in the brain.

    • Synonyms

      PDZ domain-containing protein GIPC1, GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, Tax interaction protein 2, TIP-2, GIPC1, C19orf3, GIPC, RGS19IP1, NIP, GIPC, IIP-1, SEMCAP, Hs.6454, MGC3774, GLUT1CBP, MGC15889. SYNECTIN, SYNECTIIN.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Gipc1 Human

About GIPC PDZ Domain:

GIPC PDZ domain is a member of the GIPC1 class of genes. It is a protein found in humans and is coded by the GIPC1 gene. The GIPC1 binds to the C-terminus of the RGS-GAIP. This protein helps to regulate the signalling of the G protein. GIPC1 stands for GAIP Interacting Protein C-terminus.
The RGS-GAIP protein is not alone. It interacted with several other proteins within the molecule and was discovered by several groups. As a result, this protein has several names and identifiers. It is known as C19orf3, RGS19IP1 and others. In mammals, the gene is called GIPC, as here it was discovered first. Elsewhere isn't called GIPC1, GIPC2, and GIPC3.

GIPC PDZ Domain Function
There have been three proteins of this type discovered, and they are 60% similar; they have almost identical protein sequences. GIPC1, however, has been known to interact with various other receptors and cytoskeletal proteins, unlike other members of the group. Despite some similarities and differences, the general function of the GIPC proteins seems to mediate interactions in the G protein translocation process.

GIPC PDZ Domain Interactions
Naturally, the GIPC proteins interact with various other proteins to synthesise and relocate gene data. Studies show that GIPC interacts with the melanoma’s protein TRP1 and might facilitate its tracking. But it is unknown if the GIPC affects melanoma biogenesis or melanin pigmentation. The role of GIPC proteins in gene interactions are vital to the translocation of gene data and can influence various gene processes. However, the extent of its influence is still not fully understood.