GABA(A) Receptor-Associated Protein

GABA(A) Receptor-Associated Protein

GABA(A) Receptor-Associated Protein

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  • Name :

    GABARAPL2 Human

    Description:

    GABA(A) Receptor-Associated Protein Like 2 Human Recombinant

    GABA(A) receptor-associated protein-like 2, GATE-16, GEF2, ATG8, ATG8C, Ganglioside expression factor 2, General protein transport factor p16, Golgi-associated ATPase enhancer of 16 kDa, MAP1 light chain 3-related protein, gamma-aminobutyric acid receptor-associated protein-like 2, MAP1 light chain 3 related protein, FLC3A.

    Product # :

    PRO-079

    Price :

    Quantity :

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    Description

    GABARAPL2 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 137 amino acids (1-117a.a.) and having a molecular mass of 15.8kDa. GABARAPL2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The GABARAPL2 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT and 20% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

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    • Introduction

      GABARAPL2 takes part in intra Golgi traffic and modulates intra Golgi transport by coupling between NSF activity and SNAREs activation. GABARAPL2 first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.

    • Synonyms

      GABA(A) receptor-associated protein-like 2, GATE-16, GEF2, ATG8, ATG8C, Ganglioside expression factor 2, General protein transport factor p16, Golgi-associated ATPase enhancer of 16 kDa, MAP1 light chain 3-related protein, gamma-aminobutyric acid receptor-associated protein-like 2, MAP1 light chain 3 related protein, FLC3A.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Gabarapl2 Human

  • Name :

    GABARAPL1 Human

    Description:

    GABA(A) Receptor-Associated Protein Like 1 Human Recombinant

    Gamma-aminobutyric acid receptor-associated protein-like 1, Early estrogen-regulated protein, GABA(A) receptor-associated protein-like 1, Glandular epithelial cell protein 1, GEC-1, GABARAPL1, GEC1, ATG8, APG8L, ATG8B, ATG8L, APG8-LIKE.

    Product # :

    PRO-048

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    Description

    GABARAPL1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 137 amino acids (1-117 a.a.) and having a molecular mass of 16.2kDa (Molecular size on SDS-PAGE will appear higher). The GABARAPL1 is purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The GABARAPL1 solution (1 mg/ml) contains 20mM Tris buffer (pH 8.0), 10% glycerol, 1mM DTT and 0.1M NaCl.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      GABARAPL1 [Gamma-aminobutyric acid (GABA) receptor-associated protein-like 1] is a member of the MAP1 LC3 family. GABARAPL1 increases cell surface expression of kappa type opioid receptor through facilitating anterograde intracellular trafficking of the receptor.

    • Synonyms

      Gamma-aminobutyric acid receptor-associated protein-like 1, Early estrogen-regulated protein, GABA(A) receptor-associated protein-like 1, Glandular epithelial cell protein 1, GEC-1, GABARAPL1, GEC1, ATG8, APG8L, ATG8B, ATG8L, APG8-LIKE.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Gabarapl1 Human

  • Name :

    GABARAP Human

    Description:

    GABA(A) Receptor-Associated Protein Human Recombinant

    GBRAP, MM46, GABA(A) receptor-associated protein, Gamma-aminobutyric acid receptor-associated protein, GABARAP, FLJ25768, MGC120154, MGC120155, FLC3B.

    Product # :

    PRO-775

    Price :

    Quantity :

    Shipping Method :

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    • description
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    • More Info

    Description

    GABARAP Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 137 amino acids (1-117 a.a.) and having a molecular mass of 16 kDa. GABARAP is fused to a 20 amino acid His-Tag at N-Terminus and purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    GABARAP solution (1mg/ml) containing 20mM Tris-HCl pH-8, 0.2M NaCl and 20% glycerol.

    Purity

    Greater than 95% as determined by SDS-PAGE.

    More Info

    • Introduction

      GABARAP is a ligand-gated chloride channel that mediates inhibitory neurotransmission. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton.

    • Synonyms

      GBRAP, MM46, GABA(A) receptor-associated protein, Gamma-aminobutyric acid receptor-associated protein, GABARAP, FLJ25768, MGC120154, MGC120155, FLC3B.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Gabarap Human

About GABARAP / GABA(A) Receptor-Associated Protein:

Gamma-aminobutyric acid receptor-associated protein (GABA) A is a protein found in humans, vertebrates, and invertebrates. They are ligand-gates chloride channels involved in inhibitory neurotransmission. It is encoded by the GABARAP gene in the human genome.
GABARP was initially identified and its function was discovered and clarified back in 1957. An experienced team of Canadian researchers discovered that the compound responsible for the inhibitory activity in crayfish was, in fact, GABA. The first time this activity had ever been accounted for. This was subsequently confirmed by a number of other studies.
They play an important role in the human central nervous system. Research has shown that dysfunction of GABARAP in the localization of cell membranes, can be associated with a range of server psychiatric disorders that have a confirmed diagnosis.

GABARAP Function
The main function of GABARAP is an inhibitory neurotransmitter. It is found in the brain of humans as well as other vertebrates and invertebrates. By binding to the GABA receptors, it mediates neuronal inhibition in humans, vertebrates, and invertebrates.
Mutations of the gene that encodes GABARAP have been associated with seizure activity and epilepsy.
GABA(A) subunits go to assemble type A GABARP from the pentameric chloride channels.

GABA(A) Receptor-Associated Protein Interactions
There are a number of documented and confirmed GABARP interactions that exist. In tests and through computationally derived observations, GABARAP has been seen to interact with the following:
●Transferrin receptor protein 1 (TFRC)
●ULK1
●Gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2)
Research is ongoing as to a number of other potential interactions.