Endoplasmic Reticulum Protein

Endoplasmic Reticulum Protein

Endoplasmic Reticulum Protein

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  • View Data Sheet

    Description:

    Endoplasmic Reticulum Protein 44 Human Recombinant

    PDIA10, TXNDC4, ER protein 44.

    Product # :

    PRO-547

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    Description

    ERP44 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 415 amino acids (30-406 a.a.) and having a molecular mass of 48 kDa. The ERP44 is fused to a 38 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    1mg/ml solution containing 20mM Tris-HCl pH-7.5 & 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      ERP44 is an endoplasmic reticulum chaperone that takes part in thiol-dependent retention of the primary secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. ERP44 inhibits the calcium channel activity of ITPR1. ERP44 is involved in the control of oxidative protein folding in the endoplasmic reticulum.

    • Synonyms

      PDIA10, TXNDC4, ER protein 44.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWAGSMEI TSLDTENIDE ILNNADVALV NFYADWCRFS QMLHPIFEEA SDVIKEEFPN
      ENQVVFARVD CDQHSDIAQR YRISKYPTLK LFRNGMMMKR EYRGQRSVKA LADYIRQQKS DPIQEIRDLA EITTLDRSKR NIIGYFEQKD
      SDNYRVFERV ANILHDDCAF LSAFGDVSKP ERYSGDNIIY KPPGHSAPDM VYLGAMTNFD VTYNWIQDKC VPLVREITFE NGEELTEEGL
      PFLILFHMKE DTESLEIFQN EVARQLISEK GTINFLHADC DKFRHPLLHI QKTPADCPVI AIDSFRHMYV FGDFKDVLIP GKLKQFVFDL
      HSGKLHREFH HGPDPTDTAP GEQAQDVASS PPESSFQKLA PSEYRYTLLR DRDEL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Erp44 Human
  • View Data Sheet

    Description:

    Endoplasmic Reticulum Protein 27 Human Recombinant

    Endoplasmic reticulum resident protein 27, ER protein 27, ERp27, ERP27, PDIA8, C12orf46, FLJ32115.

    Product # :

    PRO-046

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    Description

    ERP27 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 269 amino acids (26-273 a.a.) and having a molecular mass of 30kDa. The ERP27 is purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The ERP27 solution (1mg/ml) contains 20mM Tris buffer (pH 8.0), 10% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Endoplasmic reticulum protein 27kDa (ERP27) is a widely expressed protein which localizes to the ER and may act as a protease, protein disulfide isomerase, thiol-disulfide oxidase or phospholipase. ERP27 doesn’t contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.

    • Synonyms

      Endoplasmic reticulum resident protein 27, ER protein 27, ERp27, ERP27, PDIA8, C12orf46, FLJ32115.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MEVEKSSDGP GAAQEPTWLT DVPAAMEFIA ATEVAVIGFF QDLEIPAVPI LHSMVQKFPG VSFGISTDSE VLTHYNITGN TICLFRLVDN EQLNLEDEDI ESIDATKLSR FIEINSLHMV TEYNPVTVIG LFNSVIQIHL LLIMNKASPE YEENMHRYQK AAKLFQGKIL FILVDSGMKE NGKVISFFKL KESQLPALAI YQTLDDEWDT LPTAEVSVEH VQNFCDGFLS GKLLKENRES EGKTPKVEL.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Erp27 Human
  • View Data Sheet

    Description:

    ER Membrane Protein Complex Subunit 2 Human Recombinant

    ER Membrane Protein Complex Subunit 2, KIAA0103, Tetratricopeptide Repeat Domain 35, Tetratricopeptide Repeat Protein 35, TPR Repeat Protein 35, TTC35.

    Product # :

    PRO-1613

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    Description

    EMC2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 320 amino acids (1-297) and having a molecular mass of 37.2kDa.EMC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The EMC2 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 2mM DTT and 40% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      EMC2 is an element of the ER membrane protein complex. EMC2 is a member of the EMC2 family and holds 3 TPR repeats.

    • Synonyms

      ER Membrane Protein Complex Subunit 2, KIAA0103, Tetratricopeptide Repeat Domain 35, Tetratricopeptide Repeat Protein 35, TPR Repeat Protein 35, TTC35.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMAKVSEL YDVTWEEMRD KMRKWREENS RNSEQIVEVG EELINEYASK LGDDIWIIYE QVMIAALDYG RDDLALFCLQ ELRRQFPGSH RVKRLTGMRF EAMERYDDAI QLYDRILQED PTNTAARKRK IAIRKAQGKN VEAIRELNEY LEQFVGDQEA WHELAELYIN EHDYAKAAFC LEELMMTNPH NHLYCQQYAE VKYTQGGLEN LELSRKYFAQ ALKLNNRNMR ALFGLYMSAS HIASNPKASA KTKKDNMKYA SWAASQINRA YQFAGRSKKE TKYSLKAVED MLETLQITQS.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Emc2 Human

About ERP / Endoplasmic Reticulum Protein:

The endoplasmic reticulum protein is the involved transmission and transportation grounding of the eukaryotic cell. It is an organelle comprised of the rough endoplasmic reticulum and smooth endoplasmic reticulum. The former is found in cells such as hepatocytes, while the latter is commonly found in the liver and gonad cells.
It has many purposes, with its most notable being that of protein folding.

ERP Structure
The endoplasmic reticulum is structured via a thin membrane network named cisternae, formed and held by the cytoskeleton therein. The function of this involves a synthesis between the exporting of proteins and membrane lipids, depending on cell type and function. According to the metabolic processes of the cell, the amount of rough and smooth endoplasmic reticulum can shift each way in kind.

Endoplasmic Reticulum Protein Mechanism
The endoplasmic reticulum membrane has secretory proteins (in large part glycoproteins) moved across it. These proteins are marked with an ‘address tag’ known as a signal sequence. When the polypeptide reaches its endpoint, the amino acids that work as this tag are removed. As such, the ER serves as a transportation system of the eukaryotic cell, serving as a protein sorting pathway.

ERP Function
When redox regulation isn’t functioning as normal, a lack of glucose, a viral infection, or overexpression of necessary proteins can lead to an endoplasmic reticulum stress response. An abnormality in XBP1 can also lead to a heightened ERS stress response, and this can contribute to an increased chance for an inflammatory response, potentially causing a higher likelihood for diseases like Alzheimer’s and Crohn’s disease.