DiGeorge Syndrome Critical Region

DiGeorge Syndrome Critical Region

DiGeorge Syndrome Critical Region

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  • View Data Sheet

    Description:

    DiGeorge Syndrome Critical Region Gene 6-Like Human Recombinant

    Protein DGCR6L, DiGeorge syndrome critical region 6-like protein, DGCR6L.

    Product # :

    PRO-1454

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    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    DGCR6L Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 243 amino acids (1-220 a.a) and having a molecular mass of 27.3kDa.DGCR6L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    DGCR6L protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol, 1mM DTT and 250mM Imidazole.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      DiGeorge syndrome critical region 6-like protein (DGCR6L) shares homology with the Drosophila gonadal protein, it is expressed in gonadal tissues and germ cells, and with the human laminin gamma-1 chain which functions in cell attachment and migration. DGCR6L is located in a region of chromosome 22 involved in the DiGeorge syndrome, one aspect of a wider collection of anomalies referred to as the CATCH 22 syndrome. Moreover, it is one of two functional genes encoding nearly identical proteins which have analogous expression patterns.

    • Synonyms

      Protein DGCR6L, DiGeorge syndrome critical region 6-like protein, DGCR6L.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMERYAAA LEEVADGARQ QERHYQLLSA LQSLVKELPS SFQQRLSYTT LSDLALALLD GTVFEIVQGL LEIQHLTEKS LYNQRLRLQN EHRVLRQALR QKHQEAQQAC RPHNLPVVQA AQQRELEAVE HRIREEQRAM DQKIILELDR KVADQQSTLE KAGVAGFYVT TNPQELMLQM NLLELIRKLQ QRGCRAGNAA LGLGGPWQSP AAQCDQKGSP VPP.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Dgcr6L Human
  • View Data Sheet

    Description:

    DiGeorge Syndrome Critical Region Gene 6 Human Recombinant

    DiGeorge syndrome critical region gene 6, Protein DGCR6, DGCR6.

    Product # :

    PRO-1372

    Price :

    Quantity :

    Shipping Method :

    Ice Icon

    Shipped with Ice Packs

    Add To Cart

    More Info

    • description
    • source
    • formulation
    • purity
    • More Info

    Description

    DGCR6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 243 amino acids (1-220 a.a) and having a molecular mass of 27kDa. DGCR6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    DGCR6 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 20% glycerol.

    Purity

    Greater than 95% as determined by SDS-PAGE.

    More Info

    • Introduction

      DiGeorge syndrome critical region gene 6 (DGCR6) shares homology with the Drosophila melanogaster gonadal protein, that participates in gonadal and germ cell development, and also with the gamma-1 subunit of human laminin. DGCR6 is involved in DiGeorge syndrome pathology and in schizophrenia.

    • Synonyms

      DiGeorge syndrome critical region gene 6, Protein DGCR6, DGCR6.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMERYAGA LEEVADGARQ QERHYQLLSA LQSLVKELPS SFQQRLSYTT LSDLALALLD GTVFEIVQGL LEIQHLTEKS LYNQRLRLQN EHRVLRQALR QKHQEAQQAC RPHNLPVLQA AQQRELEAVE HRIREEQRAM DQKIVLELDR KVADQQSTLE KAGVAGFYVT TNPQELMLQM NLLELIRKLQ QRGCWAGKAA LGLGGPWQLP AAQCDQKGSP VPP.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Dgcr6 Human

About DGCR6 / DiGeorge Syndrome Critical Region:

DiGeorge Syndrome Critical Region is a protein found within humans and the DGCR6 gene encodes it.

DGCR6 Structure
The CATCH 22 syndrome, as well as the DiGeorge syndrome, are both linked with the microdeletions within chromosomal region 22q11.2. This gene product has the same homology as the Drosophila melanogaster gonadal protein, which participates in both the development of germ and gonadal cells.
Also, it forms the laminin molecule with the human laminin gamma-1 chain. This happens as a result of polymerizing with beta- and alpha-chain forms. Laminin will bind to the cells via interacting with the receptor. It has functions in regard to the organization of tissues, migration, and cell attachment while it is developing.

DGCR6 and DiGeorge syndrome
This gene could also be a candidate when it comes to being involved in the DiGeorge syndrome pathology in terms of acting in a neural crest cell migration role into the fourth and third pharyngeal pouches. These are the structures that are created and they surface from the organs that are impacted in DiGeorge syndrome.