Developmental Pluripotency Associated

Developmental Pluripotency Associated

Developmental Pluripotency Associated

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    Description:

    Developmental Pluripotency Associated 5 Human Recombinant

    ESG1, Developmental pluripotency-associated 5 proteins, hDPPA5, Embryonal stem cell-specific gene 1 protein, ESG-1.

    Product # :

    PRO-2136

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    Description

    DPPA5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 139 amino acids (1-116 a.a) and having a molecular mass of 15.9kDa.DPPA5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    DPPA5 protein solution (0.25mg/ml) containing 20mM Phosphate buffer (pH 8.0), and 10% glycerol.

    Purity

    Greater than 85.0% as determined by SDS-PAGE.

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    • Introduction

      Developmental pluripotency-associated 5 proteins (DPPA5) is a 116 amino acid protein, which localizes to the cytoplasm and contains one KH domain. DPPA5 is expressed in embryonic germ (EG), primordial germ (PG) and embryonic stem (ES) cells. DPPA5 has an imperative role in the maintenance of ES cell pluripotency and may be essential for proper embryogenesis.

    • Synonyms

      ESG1, Developmental pluripotency-associated 5 proteins, hDPPA5, Embryonal stem cell-specific gene 1 protein, ESG-1.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMGTLPAR RHIPPWVKVP EDLKDPEVFQ VQTRLLKAIF GPDGSRIPYIEQVSKAMLEL KALESSDLTE VVVYGSYLYK LRTKWMLQSM AEWHRQRQER GMLKLAEAMN ALELGPWMK.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Dppa5 Human
  • View Data Sheet

    Description:

    Developmental Pluripotency Associated 4 Human Recombinant

    Developmental Pluripotency Associated Protein 4, 2410091M23Rik.

    Product # :

    PRO-1546

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    Description

    DPPA4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 327 amino acids (1-304) and having a molecular mass of 35.9kDa.DPPA4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The DPPA4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 20% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      DPPA4 takes part in the conservation of active epigenetic status of target genes and prevents differentiation of embryonic cells into a primal ectoderm extraction.

    • Synonyms

      Developmental Pluripotency Associated Protein 4, 2410091M23Rik.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMLRGSAS STSMEKAKGK EWTSTEKSRE EDQQASNQPN SIALPGTSAK RTKEKMSIKG SKVLCPKKKA EHTDNPRPQK KIPIPPLPSK LPPVNLIHRD ILRAWCQQLK LSSKGQKLDA YKRLCAFAYP NQKDFPSTAK EAKIRKSLQK KLKVEKGETS LQSSETHPPE VALPPVGEPP ALENSTALLE GVNTVVVTTS APEALLASWA RISARARTPE AVESPQEASG VRWCVVHGKS LPADTDGWVH LQFHAGQAWV PEKQEGRVSA LFLLPASNFP PPHLEDNMLC PKCVHRNKVL IKSLQWE

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Dppa4 Human
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    Description:

    Developmental Pluripotency Associated 3 Human Recombinant

    Developmental pluripotency-associated protein 3, Stella-related protein, DPPA3, STELLAR, STELLA.

    Product # :

    PRO-1291

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    Description

    DPPA3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (1-159 a.a) and having a molecular mass of 20.2kDa.DPPA3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    DPPA3 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Developmental Pluripotency Associated 3 (DPPA3) is a protein which in mice may serve as a maternal factor during the preimplantation stage of development. In mice, the DPPA3 protein has a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are found on chromosomes 14 and X. DPPA3 is expressed in embryonic stem and carcinoma cells. DPPA3 has a low expression in the testis, ovary and thymus. DPPA3 is highly expressed in testicular germ cell tumors.

    • Synonyms

      Developmental pluripotency-associated protein 3, Stella-related protein, DPPA3, STELLAR, STELLA.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMDPSQFN PTYIPGSPQM LTEENSRDDS GASQISSETL IKNLSNLTIN ASSESVSPLS EALLRRESVG AAVLREIEDE WLYSRRGVRT LLSVQREKMA RLRYMLLGGV RTHERRPTNK EPKGVKKESR PFKCPCSFCV SNGWDPSENA RIGNQDTKPL QP.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Dppa3 Human

About DPPA / Developmental Pluripotency Associated:

Developmental Pluripotency Associated - or DPPA - is a specific marker of pluripotent cells. It's seen to be overexpressed in certain cancers but in this context, it's not understood all that well. It plays a very important role in the self-renewal in embryonic stem cells. There is also a clinical significance of DPPA in colon cancer.

DPPA Function
Pluripotency is the ability of a cell to shift and differentiate into any other cell type. It's a binding protein and most DPPAs show a preference for binding into regions with active chromatin signatures. DPPA encodes a protein which - according to research - could function in cell pluripotency cell control. The pseudogenes of this gene can be found on the long arm of chromosomes 14 and 19, as well as the short arm of chromosome 10.
It's one of the very few core pluripotency genes that lack a defined molecular function. It also lacks a cellular function, and while stem cells have a good potential to be within regenerative medicine, the link between pluripotency factors and tumorigenesis is a roadblock. DPPA is a gene that serves as an important role in cell self-renewal. However, as mentioned, there is a lot that is less than understood about DPPA in cancers and the underlying mechanism does still remain rather elusive. DPPA has been observed as correlating with tumor differentiation and TNM staging.
Studies have shown that developmental pluripotency-associated could play an important role in colon cancer progression. It can also function as a novel prognostic indicator as well as being a therapeutic target.