COMM Domain Containing

COMM Domain Containing

COMM Domain Containing

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  • View Data Sheet

    Description:

    COMM Domain Containing 9 Human Recombinant

    COMM Domain Containing Protein 9, FLJ31106, HSPC166, COMM9.

    Product # :

    PRO-1244

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    Description

    COMMD9 Human Recombinant produced in E. coli is a single polypeptide chain containing 221 amino acids (1-198) and having a molecular mass of 24.2 kDa. COMMD9 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The COMMD9 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.

    Purity

    Greater than 95% as determined by SDS-PAGE.

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    • Introduction

      COMM domain-containing protein 9 (COMMD9), is a part of the COMMD family. The COMMD family is a group of evolutionary conserved proteins that share a common COMM domain at their extreme C-terminus, which provides an interface for protein-protein interactions. COMMD9 is a 198 amino acid ubiquitously expressed protein which contains one COMM domain and involved in signaling events all over the cell.

    • Synonyms

      COMM Domain Containing Protein 9, FLJ31106, HSPC166, COMM9.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMAALTAE HFAALQSLLK ASSKDVVRQL CQESFSSSAL GLKKLLDVTC SSLSVTQEEA EELLQALHRL TRLVAFRDLS SAEAILALFP ENFHQNLKNL LTKIILEHVS TWRTEAQANQ ISLPRLVDLD WRVDIKTSSD SISRMAVPTC LLQMKIQEDP SLCGDKPSIS AVTVELSKET LDTMLDGLGR IRDQLSAVAS K.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Commd9 Human
  • View Data Sheet

    Description:

    COMM Domain Containing 7 Human Recombinant

    C20orf92, dJ1085F17.3.

    Product # :

    PRO-1481

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    Description

    COMMD7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 223 amino acids (1-200 a.a.) and having a molecular mass of 24.9kDa.COMMD7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    COMMD7 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      COMM Domain Containing 7 (COMMD7) composed of 200 amino acid which contains 1 COMM domain. COMMD7 interacts (through COMM domain) with COMMD1 via its COMM domain.COMMD7 also associates with the NF-kappa-B complex and suppresses its transcriptional activity. COMMD7 is highly expressed in lung.

    • Synonyms

      C20orf92, dJ1085F17.3.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMGRLHCT EDPVPEAVGG DMQQLNQLGA QQFSALTEVL FHFLTEPKEV ERFLAQLSEF ATTNQISLGS LRSIVKSLLL VPNGALKKSL TAKQVQADFI TLGLSEEKAT YFSEKWKQNA PTLARWAIGQ TLMINQLIDM EWKFGVTSGS SELEKVGSIF LQLKLVVKKG NQTENVYIEL TLPQFYSFLH EMERVRTSME CFC.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Commd7 Human
  • View Data Sheet

    Description:

    COMM Domain Containing 6 Human Recombinant

    COMM domain-containing protein 6, COMM Domain Containing 6, COMMD6, MSTP076, COMM domain-containing protein 6 isoform b, Acrg.

    Product # :

    PRO-2052

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    Description

    COMMD6 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 108 amino acids (1-85) and having a molecular mass of 12kDa.COMMD6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The COMMD6 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 20% glycerol, 0.15M NaCl and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      COMM Domain Containing (COMMD6) which is a part of the NF-kappa-B -inhibiting proteins, contains one COMM domain. COMMD6 down-regulates the activation of NF-kappa-B and inhibits TNF-induced NFKB1 activation.

    • Synonyms

      COMM domain-containing protein 6, COMM Domain Containing 6, COMMD6, MSTP076, COMM domain-containing protein 6 isoform b, Acrg.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMEASSEP PLDAKSDVTN QLVDFQWKLG MAVSSDTCRS LKYPYVAVML KVADHSGQVK TKCFEMTIPQ FQNFYRQFKE IAAVIETV.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Commd6 Human
  • View Data Sheet

    Description:

    Copper Metabolism Domain Containing 1 Human Recombinant

    MURR1, C2orf5, COMMD1, Copper Metabolism Domain Containing 1, MGC27155.

    Product # :

    PRO-862

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    Description

    COMMD1 Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 210 amino acids (1-190 a.a.) and having a molecular mass of 23.3 kDa. The COMMD1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    COMMD1 Human solution containing 20mM Tris pH-8, 0.1M NaCl & 20% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      COMMD1 is accountable for inhibition of TNF-induced NFκB p50 and n facilitats of biliary copper excretion within hepatocytes. High expression of COMMD1 is localized in liver tissue, with lower expressions in lung, heart, kidney and brain tissue. COMMD1 interacts directly with COMMD6 and ATP7B, and indirectly with IκB-β and COMMD7.

    • Synonyms

      MURR1, C2orf5, COMMD1, Copper Metabolism Domain Containing 1, MGC27155.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Commd1 Human

About COMMD / COMM Domain Containing:

The COMMD proteins often referred to as COMM Domain containing, describe a category of common proteins in multicellular organisms. These proteins are distinguished by the availability of a particular domain within the proteins' extreme carboxy-terminus.

COMMD Structure
The family of COMMD proteins comprises ten members. Each of these members has a standard structure – the C-terminal motif. Additionally, the N-terminal region of the members of the COMMD family has no homology with the proteins. The COMMD1 is considered the prototype of the COMM domain.

COMM Domain Containing Function
The COMMD family plays a significant role in the termination of NF-κB. All the protein family members have non-redundant and distinct functions in various physiological processes in the body, such as NF-κB signaling.
The COMMD proteins help regulate the transcription of NF-κB. Specifically, the COMMD1 inhibits NF-Κb, promoting the expression of various products that are useful in major body processes like oncogenesis, viral replication, inflammation, and cell survival.
Additionally, COMMD1 is used in the regulation of copper metabolism. Even though copper in the body catalyzes several enzymes, it can be dangerous if available as a free element in the body. Thus, COMMD1 helps control the intracellular levels of copper in the body. Besides being involved in copper homeostasis and NF-κB pathway inhibition, the COMM domain regulates various body functions such as calcium homeostasis, inhibitions of cell cycle transition, and sodium homeostasis.

COMMD Mechanism
The mechanism of the entire COMM domain is not entirely known. However, inferring from the interaction of COMMD1 and copper, it is clear that the protein component interacts with the ATP7B transporter in copper to deal with copper excretion.