Coiled-Coil Domain

Coiled-Coil Domain

Coiled-Coil Domain

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  • View Data Sheet

    Description:

    Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7 Human Recombinant

    Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 7, COX23 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae), COX23 Cytochrome C Oxidase Assembly Homolog , COX23, Coiled-coil-helix-coiled-coil-helix domain-containing protein 7.

    Product # :

    PRO-2083

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    Description

    CHCHD7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 120 amino acids (1-97 a.a) and having a molecular mass of 13.9kDa. CHCHD7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    CHCHD7 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.1M NaCl.

    Purity

    Greater than 90% as determined by SDS-PAGE.

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    • Introduction

      Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, also known as CHCHD7 is a newly recognized member of a multifamily of proteins which contains a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. The biological function of CHCHD7 is unknown and the gene has up till now not been connected with neoplasia. In addition, CHCHD7 & PLAG1 are located head-to-head about 500 bp apart in 8q12. Molecular analyses of twenty seven tumors exposed CHCHD7-PLAG1 fusions in three tumors, two of them had t(6;8) and t(8;15) translocations as a singular anomalies and one a normal karyotype.

    • Synonyms

      Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 7, Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 7, COX23 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae), COX23 Cytochrome C Oxidase Assembly Homolog , COX23, Coiled-coil-helix-coiled-coil-helix domain-containing protein 7.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMHQTRTG KKTVRMPSVT QRLRDPDINP CLSESDASTR CLDENNYDRE RCSTYFLRYK NCRRFWNSIV MQRRKNGVKP FMPTAAERDE ILRAVGNMPY.

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    Chchd7 Human
  • View Data Sheet

    Description:

    Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 3 Human Recombinant

    Regulatory Subunit 22, MINOS3, PPP1R22, Mitochondrial Inner Membrane Organizing System 3, Protein Phosphatase 1, Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3 Mitochondrial, Protein Phosphatase 1, Regulatory Subunit 22.

    Product # :

    PRO-815

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    Description

    CHCHD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 250 amino acids (1-227 a.a) and having a molecular mass of 28.5kDa.CHCHD3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    CHCHD3 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT.

    Purity

    Greater than 80.0% as determined by SDS-PAGE.

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    • Introduction

      Coiled-coil-helix-coiled-coil-helix domain containing 3 (CHCHD3), is a protein-coding gene. CHCHD3 is essential for maintenance of mitochondrial crista integrity and mitochondrial function. . In addition, CHCHD3 may perform as a scaffolding protein that stabilizes protein complexes involved in crista architecture and protein import. CHCHD3 may also act as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Lung cancer has been associated with CHCHD3.

    • Synonyms

      Regulatory Subunit 22, MINOS3, PPP1R22, Mitochondrial Inner Membrane Organizing System 3, Protein Phosphatase 1, Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 3 Mitochondrial, Protein Phosphatase 1, Regulatory Subunit 22.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMGGTTST RRVTFEADEN ENITVVKGIR LSENVIDRMK ESSPSGSKSQ RYSGAYGASV SDEELKRRVA EELALEQAKK ESEDQKRLKQ AKELDRERAA ANEQLTRAIL RERICSEEER AKAKHLARQL EEKDRVLKKQ DAFYKEQLAR LEERSSEFYR VTTEQYQKAA EEVEAKFKRY ESHPVCADLQ AKILQCYREN THQTLKCSAL ATQYMHCVNH AKQSMLEKGG

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    Chchd3 Human
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    Description:

    Coiled-Coil Domain Containing 90B Human Recombinant

    MDS011, MDS025, CUA003, Coiled-coil domain-containing protein 90B mitochondrial, CCDC90B.

    Product # :

    PRO-1478

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    Description

    CCDC90B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 211 amino acids (43-230 a.a) and having a molecular mass of 24.1kDa.CCDC90B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    CCDC90B protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

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    • Introduction

      Coiled-Coil Domain Containing 90B (CCDC90B) is a member of the CCDC90 family. The CCDC90B protein is distinguished by the presence of a domain of unknown function, DUF1640. The DUF1640 domain is a characteristic of the entire protein with excluding of the first 23 amino acid residues which are a mitochondrial targeting site and the cleaved CCDC90B is expected to be a mitochondrial protein with no transmembrane spans or segments. CCDC90B is predicted to contain at least 3 specific phospohorylation sites.

    • Synonyms

      MDS011, MDS025, CUA003, Coiled-coil domain-containing protein 90B mitochondrial, CCDC90B.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSGYDRRPV DITPLEQRKL TFDTHALVQD LETHGFDKTQ AETIVSALTA LSNVSLDTIY KEMVTQAQQE ITVQQLMAHL DAIRKDMVIL EKSEFANLRA ENEKMKIELD QVKQQLMHET SRIRADNKLD INLERSRVTD MFTDQEKQLM ETTTEFTKKD TQTKSIISET SNKIDAEIAS LKTLMESNKL E.

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    Ccdc90B Human
  • View Data Sheet

    Description:

    Coiled-Coil Domain Containing 69 Human Recombinant

    Coiled-coil domain-containing protein 69, CCDC69.

    Product # :

    PRO-1880

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    Description

    CCDC69 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 319 amino acids (1-296 a.a) and having a molecular mass of 37.2kDa. CCDC69 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    CCDC69 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Coiled-Coil Domain Containing 69, also known as CCDC69 is a protein-coding gene. A significant paralog of CCDC69 is MTUS1.

    • Synonyms

      Coiled-coil domain-containing protein 69, CCDC69.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMGCRHSR LSSCKPPKKK RQEPEPEQPP RPEPHELGPL NGDTAITVQL CASEEAERHQ KDITRILQQH EEEKKKWAQQ VEKERELELR DRLDEQQRVL EGKNEEALQV LRASYEQEKE ALTHSFREAS STQQETIDRL TSQLEAFQAK MKRVEESILS RNYKKHIQDY GSPSQFWEQE LESLHFVIEM KNERIHELDR RLILMETVKE KNLILEEKIT TLQQENEDLH VRSRNQVVLS RQLSEDLLLT REALEKEVQL RRQLQQEKEE LLYRVLGANA SPAFPLAPVT PTEVSFLAT.

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    Ccdc69 Human
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    Description:

    Coiled-Coil Domain Containing 43 Human Recombinant

    Coiled-coil domain containing 43, CCDC43.

    Product # :

    PRO-1419

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    Description

    CCDC43 Human Recombinant produced in E. coli is a single polypeptide chain containing 247 amino acids (1-224) and having a molecular mass of 27kDa. CCDC43 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The CCDC43 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

    Purity

    Greater than 85% as determined by SDS-PAGE.

    More Info

    • Introduction

      Coiled-Coil Domain Containing 43 (CCDC43) which is a member of the CCDC43 family is a human protein whose function is currently not understood. Coding sequence diversity are two isoforms produced by alternative splicing. Isoform 1 has been chosen as the 'canonical' sequence.

    • Synonyms

      Coiled-coil domain containing 43, CCDC43.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMAAPSEV AAIAPGEGDG GGGGFGSWLD GRLEALGVDR AVYGAYILGI LQEEEEEEKL DALQGILSAF LEEDSLLNIC KEIVERWSET QNVVTKVKKE DEVQAIATLI EKQAQIVVKP RMVSEEEKQR KAALLAQYAD VTDEEDEADE KDDSGATTMN IGSDKLLFRN TNVEDVLNAR KLERDSLRDE SQRKKEQDKL QRERDKLAKQ ERKEKEKKRT QRGERKR.

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    Ccdc43 Human
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    Description:

    Coiled-Coil Domain Containing 25 Human Recombinant

    Coiled-coil domain-containing protein 25, CCDC25.

    Product # :

    PRO-1655

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    Description

    CCDC25 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 231 amino acids (1-208 a.a) and having a molecular mass of 26.9kDa.CCDC25 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    CCDC25 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      Coiled-Coil Domain Containing 25 (CCDC25) is a 208 amino acid protein belonging to the CCDC25 family.

    • Synonyms

      Coiled-coil domain-containing protein 25, CCDC25.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMVFYFTS SSVNSSAYTI YMGKDKYENE DLIKHGWPED IWFHVDKLSS AHVYLRLHKG ENIEDIPKEV LMDCAHLVKA NSIQGCKMNN VNVVYTPWSN LKKTADMDVG QIGFHRQKDV KIVTVEKKVN EILNRLEKTK VERFPDLAAE KECRDREERN EKKAQIQEMK KREKEEMKKK REMDELRSYS SLMKVENMSS NQDGNDSDEF M.

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    Ccdc25 Human
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    Description:

    Coiled-Coil Domain Containing 23 Human Recombinant

    Coiled-Coil Domain Containing 23, CCDC23.

    Product # :

    PRO-2132

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    Description

    CCDC23 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 91 amino acids (1-66 a.a) and having a molecular mass of 10.5kDa.CCDC23 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    CCDC23 protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      Coiled-Coil Domain Containing 23, also known as CCDC23 is a 66 amino acid protein which is encoded by a gene mapping tohuman chromosome 1. Chromosome 1 is the biggest human chromosome spanning approximately 260 million base pairsand making up 8% of the human genome. In addition, there are about 3,000 genes on chromosome 1, and taking into account thehuge number of genes there are also a big number of diseases connected with chromosome 1. One of the diseasesthat have been associated with CCDC23 is endotheliitis.

    • Synonyms

      Coiled-Coil Domain Containing 23, CCDC23.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSEFMDPPA RKEKTKVKES VSRVEKAKQK SAQQELKQRQ RAEIYALNRV MTELEQQQFD EFCKQMQPPG E.

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    Ccdc23 Human
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    Description:

    Coiled-Coil Domain Containing 104 Human Recombinant

    Coiled-Coil Domain Containing 104, Coiled-CoilDomain- Protein104, CCDC104.

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    PRO-1728

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    Description

    CCDC104 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 365 amino acids (1-342 a.a) and having a molecular mass of 41.8kDa.CCDC104 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    CCDC104 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      CCDC104 also known as coiled-coil domain-containing protein 104 is a 342 amino acid protein that exists as two alternatively spliced isoforms. CCDC104 undergoes post-translational phosphorylation following DNA damage, most likely by either ATR or ATM. Among the diseases associated with CCDC104 are pancreatic cancer, and pancreatitis.

    • Synonyms

      Coiled-Coil Domain Containing 104, Coiled-CoilDomain- Protein104, CCDC104.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMAAEEED EVEWVVESIA GFLRGPDWSI PILDFVEQKC EVFDDEEESK LTYTEIHQEY KELVEKLLEG YLKEIGINED QFQEACTSPL AKTHTSQAIL QPVLAAEDFT IFKAMMVQKN IEMQLQAIRI IQERNGVLPD CLTDGSDVVS DLEHEEMKIL REVLRKSKEE YDQEEERKRK KQLSEAKTEE PTVHSSEAAI MNNSQGDGEH FAHPPSEVKM HFANQSIEPL GRKVERSETS SLPQKDLKIP GLEHASIEGP IANLSVLGTE ELRQREHYLK QKRDKLMSMR KDMRTKQIQN MEQKGKPTGE VEEMTEKPEM TAEEKQTLLK RRLLAEKLKE EVINK

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    Ccdc104 Human
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    Description:

    Coiled-Coil Domain Containing 101 Human Recombinant

    coiled-coil domain containing protein 101, SAGA-associated factor 29 homolog, SGF29, STAF36, FLJ32446.

    Product # :

    PRO-1063

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    Description

    CCDC101 Human Recombinant produced in E. coli is a single polypeptide chain containing 313 amino acids (1-293) and having a molecular mass of 35.4kDa.CCDC101 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The CCDC101 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 10% glycerol.

    Purity

    Greater than 90% as determined by SDS-PAGE.

    More Info

    • Introduction

      CCDC101 is known as a subunit of the SAGA (Spt-Ada-Gcn5 acetyltransferase) histone acetyltransferase complex in Saccharomyces cerevisiae. CCDC101 is conserved from yeast to humans.

    • Synonyms

      coiled-coil domain containing protein 101, SAGA-associated factor 29 homolog, SGF29, STAF36, FLJ32446.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MALVSADSRI AELLTELHQL IKQTQEERSR SEHNLVNIQK THERMQTENK ISPYYRTKLR GLYTTAKADA EAECNILRKA LDKIAEIKSL LEERRIAAKI AGLYNDSEPP RKTMRRGVLM TLLQQSAMTL PLWIGKPGDK PPPLCGAIPA SGDYVARPGD KVAARVKAVD GDEQWILAEV VSYSHATNKY EVDDIDEEGK ERHTLSRRRV IPLPQWKANP ETDPEALFQK EQLVLALYPQ TTCFYRALIH APPQRPQDDY SVLFEDTSYA DGYSPPLNVA QRYVVACKEP KKK

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    Ccdc101 Human

About Coiled-Coil Domain:

A coiled-coil is a type of structural motif that is found within proteins whereby alpha-helices coil together like rope strands. Read on to discover more about them.
A coiled-coil is found in proteins in all of life’s three kingdoms. Coiled-coil domains of some proteins are relatively invariant in length and sequence, betraying a functional and structural role for amino acids along the full length of the coiled-coil.

Coiled-Coil Domain Structure
The most common types are trimers and dimers.
There are some coiled-coils that are conserved in length but when it comes to sequence, they are divergent, meaning they function as molecular spacers. When in this capacity, the architecture of organelles is influenced by coiled‐coil proteins. Examples include the Golgi and centrioles, and also permitting the tethering of carrier vesicles.

Coiled-Coil Domain Structure Function
A lot of coiled-coil type proteins play a vital role in key biological functions, for example, gene expression regulation. Notable examples are the oncoproteins c-jun and c-FOS, as well as tropomyosin, which is the muscle protein.
Specialized coiled-coils, for example, those that are located in motor proteins have the capability of propagating conformational adaptions along their length, which regulate motor processivity and cargo binding.
Coiled-coil domains have been recognized in enzymes too, where they operate as molecular rulers, with catalytic activities being positioned at fixed distances.
While there has been a lot of discussion into coiled-coils for their ability to scaffold and nucleate big macromolecular complexes, there is not enough structural evidence to substantiate this claim, and so more research needs to be done.