Calcium/Calmodulin-Dependent Protein Kinase

Calcium/Calmodulin-Dependent Protein Kinase

Calcium/Calmodulin-Dependent Protein Kinase

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  • View Data Sheet

    Description:

    Calcium/Calmodulin-Dependent Protein Kinase IV Human Recombinant

    Calcium/calmodulin-dependent protein kinase type IV catalytic chain, CaMK-GR, CaM kinase-GR, CaMK IV, IV, brain Ca(2+)-calmodulin-dependent protein kinase type IV, caMK, CAM kinase IV, EC 2.7.11.17.

    Product # :

    PKA-021

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    Description

    CAMK4 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 497 amino acids (1-473) and having a molecular mass of 54.5kDa.CAMK4 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    The CAMK4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM NaCl and 10% glycerol.

    Purity

    Greater than 85% as determined by SDS-PAGE.

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    • Introduction

      CAMK4 is a member of the serine/threonine protein kinase family, and of the Ca(2+)/calmodulin-dependent protein kinase subfamily. CAMK4 is a multifunctional serine/threonine protein kinase with restricted tissue distribution which is associated to transcriptional regulation in lymphocytes, neurons and male germ cells.

    • Synonyms

      Calcium/calmodulin-dependent protein kinase type IV catalytic chain, CaMK-GR, CaM kinase-GR, CaMK IV, IV, brain Ca(2+)-calmodulin-dependent protein kinase type IV, caMK, CAM kinase IV, EC 2.7.11.17.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSHMLKVTV PSCSASSCSS VTASAAPGTA SLVPDYWIDG SNRDALSDFF EVESELGRGA TSIVYRCKQK GTQKPYALKV LKKTVDKKIV RTEIGVLLRL SHPNIIKLKE IFETPTEISL VLELVTGGEL FDRIVEKGYY SERDAADAVK QILEAVAYLH ENGIVHRDLK PENLLYATPA PDAPLKIADF GLSKIVEHQV LMKTVCGTPG YCAPEILRGC AYGPEVDMWS VGIITYILLC GFEPFYDERG DQFMFRRILN CEYYFISPWW DEVSLNAKDL VRKLIVLDPK KRLTTFQALQ HPWVTGKAAN FVHMDTAQKK LQEFNARRKL KAAVKAVVAS SRLGSASSSH GSIQESHKAS RDPSPIQDGN EDMKAIPEGE KIQGDGAQAA VKGAQAELMK VQALEKVKGA DINAEEAPKM VPKAVEDGIK VADLELEEGL AEEKLKTVEE AAAPREGQGS SAVGFEVPQQ DVILPEY.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Camk4 Human
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    Description:

    Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 Human Recombinant

    Calcium/calmodulin-dependent protein kinase II inhibitor 2, CAMK2N2, CaM-KII inhibitory protein, CaM-KIIN, CAMKIIN, Calcium/calmodulin-dependent protein kinase II.

    Product # :

    PKA-311

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    Description

    CAMK2N2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 102 amino acids (1-79a.a) and having a molecular mass of 11kDa.CAMK2N2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    E.coli.

    Formulation

    CAMK2N2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

    Purity

    Greater than 95% as determined by SDS-PAGE.

    More Info

    • Introduction

      Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 (CAMK2N2) is a protein coding gene which regulates cell growth when overexpressed in colon adenocarcinoma LoVo cells. CAMK2N2 plays a role as a cellular inhibitor of CaM-kinase II (CAMK2).

    • Synonyms

      Calcium/calmodulin-dependent protein kinase II inhibitor 2, CAMK2N2, CaM-KII inhibitory protein, CaM-KIIN, CAMKIIN, Calcium/calmodulin-dependent protein kinase II.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSEILPY SEDKMGRFGA DPEGSDLSFS CRLQDTNSFF AGNQAKRPPK LGQIGRAKRV VIEDDRIDDV LKGMGEKPPS GV.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Camk2N2 Human
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    Description:

    Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 1 Mouse Recombinant

    mCaMKIINalpha, calcium/calmodulin-dependent protein kinase II inhibitor alpha, Camk2n1.

    Product # :

    PKA-092

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    Description

    CAMK2N1 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (1-78 a.a) and having a molecular mass of 10.9kDa.CAMK2N1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    CAMK2N1 protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.5), 1mM DTT, 0.1M NaCl and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1 (CAMK2N1), which interacts with CAMK2B, is a part of the CAMK2N family. CAMK2N1 is also interacts with CAMK2A in a way which requires CAMK2A activation by Ca2+. CAMK2N1 is potent and specific inhibitor of CaM-kinase II (CAMK2).

    • Synonyms

      mCaMKIINalpha, calcium/calmodulin-dependent protein kinase II inhibitor alpha, Camk2n1.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSEVLPY GDEKLSPYGD GGDVGQIFSC RLQDTNNFFG AGQSKRPPKL GQIGRSKRVV IEDDRIDDVL KTMTDKAPPG V.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Camk2N1 Mouse
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    Description:

    Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1 Human Recombinant

    PRO1489; RP11-401M16.1, Calcium/calmodulin-dependent protein kinase II inhibitor 1, CaMKII inhibitory protein alpha, CaMKIIN-alpha, CAMK2N1.

    Product # :

    PRO-1873

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    • description
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    Description

    CAMK2N1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (1-78 a.a) and having a molecular mass of 10.9kDa. CAMK2N1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    CAMK2N1 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 1 (CAMK2N1), which interacts with CAMK2B, is a part of the CAMK2N family. CAMK2N1 is also interacts with CAMK2A in a way which requires CAMK2A activation by Ca2+. CAMK2N1 is potent and specific inhibitor of CaM-kinase II (CAMK2).

    • Synonyms

      PRO1489; RP11-401M16.1, Calcium/calmodulin-dependent protein kinase II inhibitor 1, CaMKII inhibitory protein alpha, CaMKIIN-alpha, CAMK2N1.

    • Physical Appearance

      Sterile Filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSEVLPY GDEKLSPYGD GGDVGQIFSC RLQDTNNFFG AGQNKRPPKL GQIGRSKRVV IEDDRIDDVL KNMTDKAPPG V.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Camk2N1 Human

About Calcium/Calmodulin Dependent Protein Kinase:

 CAMK, which is also commonly written as CaMK, which is the shortcut for the enzyme class known as the Ca2+/calmodulin-dependent protein kinase class. An increase in intracellular calcium ions (Ca2+) concentration causes the activation of CAMKs. When CAMKs are activated, the phosphates transfer from ATP to define threonine or serine residues into different proteins. Activated CAMK plays a role in the phosphorylation of transcription factors, and therefore, in the responding genes expression regulation. There are a lot of different members of this enzyme class. This includes SCAMK, CAMKIV, CAMKIII, CAMKII, which falls into CAMKIIγ, CAMKIIδ, CAMKIIβ, and CAMKIIα, as well as CAMKI, which falls into CAMKIγ, CAMKIδ, CAMKIβ, and CAMKIα. There are 2 main Ca2+/calmodulin-dependent protein kinase class

CaMKI
CaMKI is an enzyme that is encoded by the CAMK1 gene in humans. It is a component of the calmodulin-dependent protein kinase and it is expressed in a lot of different tissues. Calcium/calmodulin-dependent protein kinase I is directly activated by calcium/calmodulin through the enzyme being bound. This indirectly leads to the promotion of synergistic activation and phosphorylation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase.

CaMKII
Calcium/Calmodulin Dependent Protein Kinase, which is often shortened to CaMKII or CaM kinase II, is a protein kinase, which is threonine/serine-specific. The Ca2+ calmodulin complex regulates Calcium/Calmodulin Dependent Protein Kinase is thought to be a vital mediator when it comes to memory and learning, and it is incorporated in a lot of signaling cascades. It is also vital for Ca2+ homeostasis, as well as CD8 T-cell activation, positive T-cell selection, chloride transport in epithelia, and reuptake in cardiomyocytes. If it is not regulated properly, it is linked to heart arrhythmia, Angelman syndrome, and Alzheimer’s disease.
There are two different types of CaM kinase. The first is multifunctional CaM kinases. These are also known collectively as CaM kinase II. They play a key role in glycogen metabolism, transcription factor regulation, and neurotransmitter secretion. The other type of CaM is specialized CaM kinases. An example of this is myosin light chain kinase, which phosphorylates myosin. This causes the contraction of smooth muscles.
In the brain, there are many different proteins, and CaMK accounts for around one to two percent of all of them. It has 28 various isoforms. The isoform derives from the delta, gamma, beta, and alpha genes. All of the CaMK isoforms have a self-association domain, variable segment, autoinhibitory domain, and a catalytic domain. There are several binding sites in the catalytic domain for ATP and different substrate anchor proteins.