C-Reactive Protein

C-Reactive Protein

C-Reactive Protein

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    Name :

    CRP Rat

    Description:

    C-Reactive Protein Rat Recombinant

    Ptx1, C-reactive protein, Pentraxin 1, C-Reactive Protein Pentraxin-Related.

    Product # :

    PRO-1421

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    Description

    CRP produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 217 amino acids (20-230 a.a.) and having a molecular mass of 24.1kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40 kDa).CRP is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

    Source

    Sf9, Insect cells.

    Formulation

    CRP protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

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    • Introduction

      CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.

    • Synonyms

      Ptx1, C-reactive protein, Pentraxin 1, C-Reactive Protein Pentraxin-Related.

    • Physical Appearance

      Sterile filtered colorless solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      HEDMSKQAFV FPGVSATAYV SLEAESKKPL EAFTVCLYAH ADVSRSFSIF SYATKTSFNE ILLFWTRGQG FSIAVGGPEI LFSASEIPEV PTHICATWES ATGIVELWLD GKPRVRKSLQ KGYIVGTNAS IILGQEQDSY GGGFDANQSL VGDIGDVNMW DFVLSPEQIN AVYVGRVFSP NVLNWRALKY ETHGDVFIKP QLWPLTDCCE SHHHHHH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Crp Rat
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    Description:

    C-Reactive Protein Mouse Recombinant

    C-reactive protein, pentraxin-related, Crp.

    Product # :

    PRO-2630

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    Description

    CRP Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 214 amino acids (20-225 a.a) and having a molecular mass of 24.1 kDa. CRP is fused to a 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

    Source

    Sf9, Baculovirus cells.

    Formulation

    CRP solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.1M PMSF and 40% glycerol.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      C-Reactive Protein or CRP, is a protein, part of the pentraxin superfamily. Among the protein’s activities, CRP can promote agglutination, swelling of the bacteria capsule, phagocytosis etc. this protein can also cause complement fixation via a calcium-dependent binding to the molecule phosphorylcholine.

    • Synonyms

      C-reactive protein, pentraxin-related, Crp.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      HEDMFKKAFV FPKESDTSYV SLEAESKKPL NTFTVCLHFY TALSTVRSFS VFSYATKKNS NDILIFWNKD KQYTFGVGGA EVRFMVSEIP EAPTHICASW ESATGIVEFW IDGKPKVRKS LHKGYTVGPD ASIILGQEQD SYGGDFDAKQ SLVGDIGDVN MWDFVLSPEQ ISTVYVGGTL SPNVLNWRAL NYKAQGDVFI KPQLWSLEHH HHHH.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Crp Mouse
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    Description:

    c-Reactive Protein Human Recombinant

    C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    Product # :

    PRO-335

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    • sds-page

    Description

    Recombinant Human CRP produced in E.Coli is a non-glycosylated polypeptide chain having a total molecular mass of 115 kDa that corresponds to the pentamer structure of 23 kDa monomer determined by amino acid sequence. The CRP is purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    The sterile protein solution contains 20mM Tris (pH 7.5), 2mM CaCl2, 0.14M NaCl and 0.05% NaN3.

    Purity

    Greater than 95.0% as determined by Analysis by SDS-PAGE.

    sds-page

    More Info

    • Introduction

      CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.

    • Synonyms

      C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      CRP should be stored at all times at 4°C.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    C Reactive Protein Human Recombinant
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    Description:

    C-Reactive Protein Human

    C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    Product # :

    PRO-557

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    Description

    Human CRP produced in Human plasma having a molecular mass of 114 kDa. It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease.

    Source

    Human Plasma.

    Formulation

    The protein solution is in 20mM TRIS buffer pH 8.0 containing 0.28M NaCl, 0.09% NaN3 and 5mM CaCl2.

    Purity

    Greater than 96.0%.

    More Info

    • Introduction

      CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically ( up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.

    • Synonyms

      C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Human CRP should be stored at 2-8°C. Do not freeze!

    • Human Virus Test

      Starting material donor has been tested and certified negative for antibodies to HIV-1, HIV-2, HCV, HBSAG and HIV/HBV/HCV (PCR).

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    CRP Human - Prospecbio
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    Description:

    C-Reactive Protein Canine Recombinant

    C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    Product # :

    PRO-2663

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    Shipped at Room temp

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    Description

    CRP Canine Recombinant is a single, glycosylated polypeptide chain containing 204 amino acids and having a molecular mass of 23.2kDa (calculated).

    Source

    HEK293 cells.

    Formulation

    CRP filtered (0.4 µm) and lyophilized from 0.5mg/ml in 20mM Tris, 50mM NaCl and 1mM CaCl2, pH 7.5.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.

    • Synonyms

      C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    • Physical Appearance

      Filtered White lyophilized (freeze-dried) powder.

    • Stability

      Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

    • Solubility

      It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely.

    • Amino Acid Sequence

      QIDLDEKAFV FPRESENSYV ILFPQLQKPM KAFTVCLQVY TDLTRPHSLF SYATKSQSNE ILLFKERPGL FSVSVGGSDA FINFPQKFYA PQHFCVTWES VTGLTELWVD GKPMVRASLR RGYTVGSGAS IVLGQEQDSF GGGFDKNQSL VGDIEDVNMW DFVLSPSQIL TLYTTRALSP NVLNWRNLRY ETRGEVFLKK ELWS

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    CRP Canine - Prospecbio
  • View Data Sheet

    Description:

    c-Reactive Protein (19-224 a.a) Human Recombinant

    C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    Product # :

    PRO-914

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    Description

    CRP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 207 amino acids (19-224 a.a.) and having a molecular mass of 23.2kDa.CRP is purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    CRP protein solution (1mg/ml) containing 20mM Tris-HCl, pH8.0, 2M Urea and 20% Glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.

    • Synonyms

      C-reactive protein, CRP, PTX1, MGC88244, MGC149895.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MQTDMSRKAF VFPKESDTSY VSLKAPLTKP LKAFTVCLHF YTELSSTRGY SIFSYATKRQ DNEILIFWSK DIGYSFTVGG SEILFEVPEV TVAPVHICTS WESASGIVEF WVDGKPRVRK SLKKGYTVGA EASIILGQEQ DSFGGNFEGS QSLVGDIGNV NMWDFVLSPD EINTIYLGGP FSPNVLNWRA LKYEVQGEVF TKPQLWP.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    CRP (19-224 a.a) Human - Prospecbio

About CRP / C-reactive protein:

C-reactive protein (CRP) is a protein that is found in blood plasma. Its levels within the body rise in response to inflammation. It plays a key role in the body’s early defense against infection.
CRP is classified as part of the pentraxin family and has the honor of being the first pattern recognition receptor to be definitively identified by researchers.

CRP Structure
The gene for CRP was identified on chromosome 1. It has a molecular mass of 25,106 Da and 224 amino acids.

C-reactive protein Function
CRP has been found to bind itself to lysophosphatidylcholine on the surface of cells that are dead or dying. This binding activates the complement system, clearing apoptotic and necrotic cells.
The CRP response occurs in both acute and chronic inflammatory instances. These can be fungal, bacterial, or viral in nature. It can also occur in response to tissue injury, necrosis, and certain malignancies.
As a result of these conditions, the body produces interleukin-6 and cytokines which in turn trigger the production of CRP in the liver.

CRP As A Diagnostic Tool
CRP levels are measured as a marker for inflammation inside the body. CRP levels can be used in the detection, monitoring, and diagnosis of many illnesses and diseases. Cardiovascular disease and coronary heart disease, Fibrosis, Cancer, Sleep apnea, Rheumatoid arthritis, Viral and bacterial infection.
CRP production is unaffected by almost all factors excluding those of liver failure and the use of the drug interferon-alpha, which is used to treat viruses and certain types of cancer.