Bromodomain Containing

Bromodomain Containing

Bromodomain Containing

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  • View Data Sheet

    Description:

    Bromodomain Containing 3 Human Recombinant

    ORFX, RING3L, Bromodomain-containing protein 3, RING3-like protein, KIAA0043, RING3L.

    Product # :

    PRO-2143

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    Description

    BRD3 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 439 amino acids (1-416 a.a) and having a molecular mass of 48.1kDa.BRD3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    BRD3 protein solution (0.5mg/ml) containing PBS buffer (pH 7.4) and 10% glycerol.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

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    • Introduction

      Bromodomain Containing 3 (BRD3) was classified based on its homology to the gene encoding the RING3 protein, which is a serine/threonine kinase. The BRD3 protein localizes to 9q34, a region which contains a number of major histocompatibility complex (MHC) genes. The function of the BRD3 protein is unknown.

    • Synonyms

      ORFX, RING3L, Bromodomain-containing protein 3, RING3-like protein, KIAA0043, RING3L.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMSTATTV APAGIPATPG PVNPPPPEVS NPSKPGRKTN QLQYMQNVVV KTLWKHQFAW PFYQPVDAIK LNLPDYHKII KNPMDMGTIK KRLENNYYWS ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ ALEKIFLQKV AQMPQEEVEL LPPAPKGKGR KPAAGAQSAG TQQVAAVSSV SPATPFQSVP PTVSQTPVIA ATPVPTITAN VTSVPVPPAA APPPPATPIV PVVPPTPPVV KKKGVKRKAD TTTPTTSAIT ASRSESPPPL SDPKQAKVVA RRESGGRPIK PPKKDLEDGE VPQHAGKKGK LSEHLRYCDS ILREMLSKKH AAYAWPFYKP VDAEALELHD YHDIIKHPMD LSTVKRKMDG REYPDAQGFA ADVRLMFSNC YKYNPPDHEV VAMARKLQDV FEMRFAKMP.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Brd3 Human
  • View Data Sheet

    Description:

    Bromodomain Containing 2 Human Recombinant

    Bromodomain Containing 2, RING3, Really Interesting New Gene 3 Protein, Bromodomain-Containing 2, O27.1.1, FSRG1, Female Sterile Homeotic-Related Gene 1, Bromodomain-Containing Protein 2, KIAA9001, D6S113E, RNF3, FSH, NAT, Bromodomain-containing protein 2 .

    Product # :

    PRO-2122

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    Description

    BRD2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 478 amino acids (1-455 a.a) and having a molecular mass of 52.8kDa. BRD2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    BRD2 protein solution (1mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.

    Purity

    Greater than 90.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Bromodomain Containing 2, also known as BRD2 is a transcriptional regulator which is a member of the BET, bromodomains and extra terminaldomain, family of roteins. BRD2 links with transcription complexes and it acetylated chromatin in the course of mitosis, and it selectively binds o the acetylated lysine-12 residue of histone H4 through its two romodomains. BRD2 maps to the major histocompatability complex MHC) class II region on chromosome 6p21.3, however sequencecomparison advocate that the protein is not implicated in the immune response. BRD2 has been implicated injuvenile myoclonic epilepsy, a common form of epilepsy which grows to be visible in adolescence.

    • Synonyms

      Bromodomain Containing 2, RING3, Really Interesting New Gene 3 Protein, Bromodomain-Containing 2, O27.1.1, FSRG1, Female Sterile Homeotic-Related Gene 1, Bromodomain-Containing Protein 2, KIAA9001, D6S113E, RNF3, FSH, NAT, Bromodomain-containing protein 2 .

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSMLQNVTP HNKLPGEGNA GLLGLGPEAA APGKRIRKPS LLYEGFESPT MASVPALQLT PANPPPPEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKII KQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQG SVTSAHQVPA VSSVSHTALY TPPPEIPTTV LNIPHPSVIS SPLLKSLHSA GPPLLAVTAA PPAQPLAKKK GVKRKADTTT PTPTAILAPG SPASPPGSLE PKAARLPPMR RESGRPIKPP RKDLPDSQQQ HQSSKKGKLS EQLKHCNGIL KELLSKKHAA YAWPFYKPVD ASALGLHDYH DIIKHPMDLS TVKRKMENRD YRDAQEFAAD VRLMFSNCYK YNPPDHDVVA MARKLQDVFE FRYAKMPD.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Brd2 Human
  • View Data Sheet

    Description:

    Bromodomain Containing 1 Human Recombinant

    Bromodomain Containing 1, BRL, Bromodomain And PHD Finger-Containing Protein2, BR140-Like Protein, BRPF2, Bromodomain-Containing Protein 1, Bromodomain-Containing 1, BR140-Like, BRPF1, BRD1.

    Product # :

    PRO-2117

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    Description

    BRD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 156 amino acids (556-688 a.a) and having a molecular mass of 17.8kDa.BRD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

    Source

    Escherichia Coli.

    Formulation

    BRD1 protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.

    Purity

    Greater than 95.0% as determined by SDS-PAGE.

    More Info

    • Introduction

      Bromodomain Containing 1 also known as BRD1 contains a bromodomain, which is a sequence motif frequently found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types. Variations in BRD1 are connected with schozophrenia & bipolar disorder.

    • Synonyms

      Bromodomain Containing 1, BRL, Bromodomain And PHD Finger-Containing Protein2, BR140-Like Protein, BRPF2, Bromodomain-Containing Protein 1, Bromodomain-Containing 1, BR140-Like, BRPF1, BRD1.

    • Physical Appearance

      Sterile Filtered clear solution.

    • Stability

      Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

    • Amino Acid Sequence

      MGSSHHHHHH SSGLVPRGSH MGSEQVAMEL RLTPLTVLLR SVLDQLQDKD PARIFAQPVS LKEVPDYLDH IKHPMDFATM RKRLEAQGYK NLHEFEEDFD LIIDNCMKYN ARDTVFYRAA VRLRDQGGVV LRQARREVDS IGLEEASGMH LPERPA.

    ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

    Brd1 Human

About BRD / Bromodomain Containing:

A bromodomain, or BRD, is an amino acid protein domain that is capable of recognizing acetylated lysine residues and regulating gene expression. By reading these lysine residues, BRD carriy and translate the signal released by acetylated lysine residues into phenotypes.

BRD Function
BRD-containing proteins have multiple and varied functions. Bromodomain and extra-terminal domain (BET) is perhaps, the most well-known example of a BRD containing protein, although ASH1L also contains bromodomain.

Bromodomain Containing Mechanism
BRD proteins read acetylation marks on histones and convert the signal released into observable characteristics, or phenotypes. The presence of BRD is often necessary for chromatin remodeling and a protein-histone association to occur. Studies have shown that BRD translates deregulated cell acetylome into phenotypes associated with diseases, including cancer and multiple sclerosis (MS). Additionally, BRD-containing proteins have been found in oncogenic fusion proteins, which result from chromosomal rearrangements.

BRD Interactions
Bromodomain containing proteins have been shown to interact with a variety of materials, including ATAD2, BAZ2B, BPTF, BRD2, BRD3, BRD4, BRDT, BRD7, CECR2, CREBBP, EP300, GCN5, KIAA1240, all 6 single domains of PB1, PCAF, SMARCA2, SMARCA4, TAF1, TIF1a (PHD/BRD), TRIM33A (PHD/BRD).
Due to the role of BRD in human diseases, BRD inhibitors are now being used in clinical trials to determine whether they can be used to effectively treat cancers.

Bromodomain Containing Structure
BRD presents as an all-α protein fold and features a bundle of four alpha helices. Each of these alpha helices are separated by loop regions. These loop regions are present in varying lengths and form a hydrophobic pocket, which facilitates the recognition of acetyl-lysine.